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Targeting potassium channels in cancer.
Huang X, Jan LY. Huang X, et al. J Cell Biol. 2014 Jul 21;206(2):151-62. doi: 10.1083/jcb.201404136. J Cell Biol. 2014. PMID: 25049269 Free PMC article. Review.
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. Huang X, et al. Nat Neurosci. 2015 Sep;18(9):1236-46. doi: 10.1038/nn.4088. Epub 2015 Aug 10. Nat Neurosci. 2015. PMID: 26258683 Free PMC article.
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. Huang X, et al. Genes Dev. 2012 Aug 15;26(16):1780-96. doi: 10.1101/gad.193789.112. Epub 2012 Aug 1. Genes Dev. 2012. PMID: 22855790 Free PMC article.