R56 GM067308/GM/NIGMS NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2007	1
2008	2
2009	2
2010	2
2012	3
2013	4
2014	2
2015	1
2016	2
2017	1
2024	0

1

Interaction between midazolam and clarithromycin in the elderly.

Quinney SK, Haehner BD, Rhoades MB, Lin Z, Gorski JC, Hall SD. Quinney SK, et al. Br J Clin Pharmacol. 2008 Jan;65(1):98-109. doi: 10.1111/j.1365-2125.2007.02970.x. Epub 2007 Jul 17. Br J Clin Pharmacol. 2008. PMID: 17635500 Free PMC article. Clinical Trial.

2

Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin.

Quinney SK, Malireddy SR, Vuppalanchi R, Hamman MA, Chalasani N, Gorski JC, Hall SD. Quinney SK, et al. Eur J Clin Pharmacol. 2013 Mar;69(3):439-48. doi: 10.1007/s00228-012-1339-x. Epub 2012 Jul 10. Eur J Clin Pharmacol. 2013. PMID: 22777148 Free PMC article. Clinical Trial.

3

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent.

Michaud V, Kreutz Y, Skaar T, Ogburn E, Thong N, Flockhart DA, Desta Z. Michaud V, et al. Pharmacogenomics J. 2014 Apr;14(2):151-9. doi: 10.1038/tpj.2013.17. Epub 2013 Apr 30. Pharmacogenomics J. 2014. PMID: 23629159 Free PMC article.

4

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Cho DY, Shen JH, Lemler SM, Skaar TC, Li L, Blievernicht J, Zanger UM, Kim KB, Shin JG, Flockhart DA, Desta Z. Cho DY, et al. Drug Metab Pharmacokinet. 2016 Apr;31(2):107-16. doi: 10.1016/j.dmpk.2015.07.002. Epub 2015 Jul 29. Drug Metab Pharmacokinet. 2016. PMID: 27053325 Free PMC article. Clinical Trial.

5

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition.

Robarge JD, Metzger IF, Lu J, Thong N, Skaar TC, Desta Z, Bies RR. Robarge JD, et al. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01813-16. doi: 10.1128/AAC.01813-16. Print 2017 Jan. Antimicrob Agents Chemother. 2016. PMID: 27799204 Free PMC article. Clinical Trial.

6

CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling.

Xu C, Quinney SK, Guo Y, Hall SD, Li L, Desta Z. Xu C, et al. Drug Metab Dispos. 2013 Dec;41(12):2004-11. doi: 10.1124/dmd.113.051755. Epub 2013 Jul 11. Drug Metab Dispos. 2013. PMID: 23846872 Free PMC article. Clinical Trial.

7

In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19.

Xu C, Desta Z. Xu C, et al. Drug Metab Pharmacokinet. 2013;28(4):362-71. doi: 10.2133/dmpk.dmpk-12-rg-124. Epub 2013 Feb 5. Drug Metab Pharmacokinet. 2013. PMID: 23385314 Free PMC article.

8

Effects of the CYP2B6*6 allele on catalytic properties and inhibition of CYP2B6 in vitro: implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo.

Xu C, Ogburn ET, Guo Y, Desta Z. Xu C, et al. Drug Metab Dispos. 2012 Apr;40(4):717-25. doi: 10.1124/dmd.111.042416. Epub 2012 Jan 9. Drug Metab Dispos. 2012. PMID: 22232427 Free PMC article.

9

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.

Metzger IF, Quigg TC, Epstein N, Aregbe AO, Thong N, Callaghan JT, Flockhart DA, Nguyen AT, Stevens CK, Gupta SK, Desta Z. Metzger IF, et al. Curr Ther Res Clin Exp. 2014 Sep 27;76:64-9. doi: 10.1016/j.curtheres.2014.05.002. eCollection 2014 Dec. Curr Ther Res Clin Exp. 2014. PMID: 25352936 Free PMC article.

10

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers.

Michaud V, Ogburn E, Thong N, Aregbe AO, Quigg TC, Flockhart DA, Desta Z. Michaud V, et al. Clin Pharmacol Ther. 2012 Mar;91(3):475-82. doi: 10.1038/clpt.2011.249. Epub 2012 Feb 8. Clin Pharmacol Ther. 2012. PMID: 22318618 Free PMC article. Clinical Trial.

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