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RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway.
Huang F, Dai Z, Yu J, Wang K, Chen C, Chen D, Zhang J, Zhao J, Li M, Zhang W, Li X, Qi Y, Wang Y. Huang F, et al. Elife. 2024 Jul 12;13:RP95318. doi: 10.7554/eLife.95318. Elife. 2024. PMID: 38995840 Free PMC article.
Here, we unveiled that RBM7 is decreased in lymph node and distant organ metastases of breast cancer as compared to primary lesions and low expression of RBM7 is correlated with the reduced disease-free survival of breast cancer patients. Breast can …
Here, we unveiled that RBM7 is decreased in lymph node and distant organ metastases of breast cancer as compared to primary le …
Oncogenic action of the exosome cofactor RBM7 by stabilization of CDK1 mRNA in breast cancer.
Xi PW, Zhang X, Zhu L, Dai XY, Cheng L, Hu Y, Shi L, Wei JF, Ding Q. Xi PW, et al. NPJ Breast Cancer. 2020 Oct 30;6:58. doi: 10.1038/s41523-020-00200-w. eCollection 2020. NPJ Breast Cancer. 2020. PMID: 33145401 Free PMC article.
However, the specific function of RBM7 in human breast cancer remains unclear. In vitro, experiments revealed that knockdown of RBM7 dramatically inhibited breast cancer cell proliferation, while inducing G1 cell cycle arrest; the opposite was true whe …
However, the specific function of RBM7 in human breast cancer remains unclear. In vitro, experiments revealed that knockdown o …
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Puno MR, Lima CD. Puno MR, et al. Cell. 2022 Jun 9;185(12):2132-2147.e26. doi: 10.1016/j.cell.2022.04.016. Cell. 2022. PMID: 35688134 Free PMC article.
The structures illuminate ZCCHC8 as a scaffold, mediating homodimerization while embracing the MTR4 helicase and flexibly anchoring RBM7 to the helicase core. All three subunits collaborate to bind the RNA, with RBM7 and ZCCHC8 surveying sequences upstream of the 3' …
The structures illuminate ZCCHC8 as a scaffold, mediating homodimerization while embracing the MTR4 helicase and flexibly anchoring RBM7 …
The RNA exosome and RNA exosome-linked disease.
Morton DJ, Kuiper EG, Jones SK, Leung SW, Corbett AH, Fasken MB. Morton DJ, et al. RNA. 2018 Feb;24(2):127-142. doi: 10.1261/rna.064626.117. Epub 2017 Nov 1. RNA. 2018. PMID: 29093021 Free PMC article. Review.
A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.
Blasius M, Wagner SA, Choudhary C, Bartek J, Jackson SP. Blasius M, et al. Genes Dev. 2014 Sep 15;28(18):1977-82. doi: 10.1101/gad.246272.114. Epub 2014 Sep 4. Genes Dev. 2014. PMID: 25189701 Free PMC article.
These include the nuclear exosome targeting (NEXT) complex that regulates turnover of noncoding RNAs termed promoter upstream transcripts (PROMPTs). We show that the NEXT subunit RBM7 is phosphorylated upon DNA damage by the MAPKAPK2 kinase and establish that this mediates …
These include the nuclear exosome targeting (NEXT) complex that regulates turnover of noncoding RNAs termed promoter upstream transcripts (P …
Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders.
Schratz KE, Gaysinskaya V, Cosner ZL, DeBoy EA, Xiang Z, Kasch-Semenza L, Florea L, Shah PD, Armanios M. Schratz KE, et al. J Clin Invest. 2021 Sep 15;131(18):e147598. doi: 10.1172/JCI147598. J Clin Invest. 2021. PMID: 34343137 Free PMC article.
Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers overcome the inherited telomere defect is unknown.METHODSWe used ultra-deep targeted sequencing to detect somatic reversion mutations in 17 cand …
Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers over …