Abstract
Recent advances in cellular, molecular, and developmental biology have revolutionized our concepts regarding the process of organogenesis that have important implications for our understanding of both lung formation and pulmonary disease pathogenesis. Pulmonary investigators have long debated whether developmental processes are recapitulated during normal repair of the lung or in the setting of chronic pulmonary diseases. Although the cellular events involved in lung morphogenesis and those causing pulmonary disease are likely to include processes that are distinct, there is increasing evidence that the pathogenesis of many lung disorders involves the same genetic machinery that regulates cell growth,specification, and differentiation during normal lung development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation
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Cell Lineage
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Chronic Disease
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DNA-Binding Proteins / metabolism
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Embryonic Development
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Embryonic Stem Cells / cytology
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Fetal Development
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Hepatocyte Nuclear Factor 3-beta / metabolism
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Humans
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Inflammation / metabolism
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Lung / cytology
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Lung / embryology*
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Lung / growth & development*
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Lung Diseases / genetics
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Lung Diseases / physiopathology*
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Metaplasia / metabolism
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Morphogenesis / genetics
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Pluripotent Stem Cells / cytology
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Proto-Oncogene Proteins c-ets / metabolism
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Receptors, Notch / metabolism
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Respiratory Mucosa / cytology
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Respiratory Mucosa / embryology
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Respiratory Mucosa / growth & development
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SOXB1 Transcription Factors / metabolism
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Signal Transduction / physiology
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Tissue Culture Techniques
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Transcription Factors
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Transcription, Genetic
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Wound Healing / genetics
Substances
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DNA-Binding Proteins
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FOXA2 protein, human
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Proto-Oncogene Proteins c-ets
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Receptors, Notch
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SOX2 protein, human
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SOXB1 Transcription Factors
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SPDEF protein, human
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TTF1 protein, human
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Transcription Factors
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Hepatocyte Nuclear Factor 3-beta