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1994 2
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2003 15
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219 results

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Page 1
Clinical implications of germline mutations in breast cancer genes: RECQL.
Bowden AR, Tischkowitz M. Bowden AR, et al. Breast Cancer Res Treat. 2019 Apr;174(3):553-560. doi: 10.1007/s10549-018-05096-6. Epub 2019 Jan 4. Breast Cancer Res Treat. 2019. PMID: 30610487 Free PMC article. Review.
Several subsequent studies in independent patient cohorts have provided further data on RECQL variant frequency in additional populations, some of which have brought in to question the increased breast cancer risk associated with RECQL mutations. ...An Australian ca …
Several subsequent studies in independent patient cohorts have provided further data on RECQL variant frequency in additional populat …
High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival.
Mahmoodi A, Shoqafi A, Sun P, Giannakeas V, Cybulski C, Nofech-Mozes S, Masson JY, Sharma S, Samani AA, Madhusudan S, Narod SA, Akbari MR. Mahmoodi A, et al. Front Oncol. 2022 May 31;12:877617. doi: 10.3389/fonc.2022.877617. eCollection 2022. Front Oncol. 2022. PMID: 35712517 Free PMC article.
BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported. ...CONCLUSION: RECQL might …
BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high leve …
RECQL: a DNA helicase in breast cancer.
Akbari MR, Cybulski C. Akbari MR, et al. Oncotarget. 2015 Sep 29;6(29):26558-9. doi: 10.18632/oncotarget.5452. Oncotarget. 2015. PMID: 26387136 Free PMC article. No abstract available.
The RECQL helicase prevents replication fork collapse during replication stress.
Benedict B, van Bueren MA, van Gemert FP, Lieftink C, Guerrero Llobet S, van Vugt MA, Beijersbergen RL, Te Riele H. Benedict B, et al. Life Sci Alliance. 2020 Aug 20;3(10):e202000668. doi: 10.26508/lsa.202000668. Print 2020 Oct. Life Sci Alliance. 2020. PMID: 32820027 Free PMC article.
In line with these findings, knockdown of RECQL in different cancer cells increased the level of DNA DSBs. Thus, RECQL plays a critical role in sustaining DNA synthesis under conditions of replication stress and as such may represent a target for cancer therapy....
In line with these findings, knockdown of RECQL in different cancer cells increased the level of DNA DSBs. Thus, RECQL plays a …
RECQL: a new breast cancer susceptibility gene.
Banerjee T, Brosh RM Jr. Banerjee T, et al. Cell Cycle. 2015;14(22):3540-3. doi: 10.1080/15384101.2015.1066539. Cell Cycle. 2015. PMID: 26125302 Free PMC article.
RECQL pathogenic mutations were identified that truncated or disrupted the RECQL protein or introduced missense mutations in its helicase domain. RECQL mutations may serve as a useful biomarker for breast cancer. ...
RECQL pathogenic mutations were identified that truncated or disrupted the RECQL protein or introduced missense mutations in i …
Germline RECQL mutations in high risk Chinese breast cancer patients.
Kwong A, Shin VY, Cheuk IWY, Chen J, Au CH, Ho DN, Chan TL, Ma ESK, Akbari MR, Narod SA. Kwong A, et al. Breast Cancer Res Treat. 2016 Jun;157(2):211-215. doi: 10.1007/s10549-016-3784-1. Epub 2016 Apr 28. Breast Cancer Res Treat. 2016. PMID: 27125668
Recently, RECQL was reported as a new breast cancer susceptibility gene. RECQL belongs to the RECQ DNA helicase family which unwinds double strand DNA and involved in the DNA replication stress response, telomere maintenance and DNA repair. RECQL deficient mi …
Recently, RECQL was reported as a new breast cancer susceptibility gene. RECQL belongs to the RECQ DNA helicase family which u …
Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers.
Liu NN, Song ZY, Guo HL, Yin H, Chen WF, Dai YX, Xin BG, Ai X, Ji L, Wang QM, Hou XM, Dou SX, Rety S, Xi XG. Liu NN, et al. Cell Rep. 2021 Sep 7;36(10):109688. doi: 10.1016/j.celrep.2021.109688. Cell Rep. 2021. PMID: 34496242 Free article.
This conclusion is based mainly on studies of highly purified recombinant proteins, and the oligomeric states of RecQ helicases in living cells remain unknown. We show here that, in contrast to current models, monomeric RECQL helicase is more abundant than oligomer/dimer f …
This conclusion is based mainly on studies of highly purified recombinant proteins, and the oligomeric states of RecQ helicases in living ce …
Prevalence of RECQL germline variants in Pakistani early-onset and familial breast cancer patients.
Rashid MU, Muhammad N, Khan FA, Shehzad U, Naeemi H, Malkani N, Hamann U. Rashid MU, et al. Hered Cancer Clin Pract. 2020 Dec 20;18(1):25. doi: 10.1186/s13053-020-00159-6. Hered Cancer Clin Pract. 2020. PMID: 33342430 Free PMC article.
Here, we investigated the contribution of pathogenic RECQL germline variants to hereditary breast cancer in early-onset and familial breast cancer patients from Pakistan. ...All variants were absent in 250 controls. CONCLUSIONS: Our data suggest that the RECQL gene …
Here, we investigated the contribution of pathogenic RECQL germline variants to hereditary breast cancer in early-onset and familial …
Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer.
Sun J, Wang Y, Xia Y, Xu Y, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Lou H, Xie Y. Sun J, et al. PLoS Genet. 2015 May 6;11(5):e1005228. doi: 10.1371/journal.pgen.1005228. eCollection 2015 May. PLoS Genet. 2015. PMID: 25945795 Free PMC article.
Therefore, we further screened the RECQL gene in an additional 439 unrelated familial breast cancer patients. In total, we found three nonsense mutations leading to a truncated protein of RECQL (p.L128X, p.W172X, and p.Q266X), one mutation affecting mRNA splicing (c …
Therefore, we further screened the RECQL gene in an additional 439 unrelated familial breast cancer patients. In total, we found thre …
Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients.
Xu H, Xu Y, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Xie Y. Xu H, et al. BMC Cancer. 2018 Jun 18;18(1):662. doi: 10.1186/s12885-018-4585-1. BMC Cancer. 2018. PMID: 29914420 Free PMC article.
Here, we explored the association between RECQL expression level and survival in patients with breast cancer. ...CONCLUSIONS: Breast cancer patients with low RECQL expression had a worse survival. The expression level of RECQL may be a potential prognosis fac …
Here, we explored the association between RECQL expression level and survival in patients with breast cancer. ...CONCLUSIONS: Breast …
219 results