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Did you mean rec (92,597 results)?
Germline RECQL gene mutations in Chinese patients with breast cancer.
Hu J, Shen Y, Zhang K, Chen Y. Hu J, et al. Front Med (Lausanne). 2024 Feb 19;11:1366769. doi: 10.3389/fmed.2024.1366769. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38439896 Free PMC article.
INTRODUCTION: Breast cancer is the most common malignant tumor in women, seriously threatening health and survival. TP-dependent DNA helicase Q1 (RECQL) is a breast cancer susceptibility gene with possible familial links. However, RECQL gene mutations among Chinese …
INTRODUCTION: Breast cancer is the most common malignant tumor in women, seriously threatening health and survival. TP-dependent DNA helicas …
Clinical implications of germline mutations in breast cancer genes: RECQL.
Bowden AR, Tischkowitz M. Bowden AR, et al. Breast Cancer Res Treat. 2019 Apr;174(3):553-560. doi: 10.1007/s10549-018-05096-6. Epub 2019 Jan 4. Breast Cancer Res Treat. 2019. PMID: 30610487 Free PMC article. Review.
In 2015, two independent studies provided initial evidence for a novel breast cancer susceptibility gene, RECQL, a DNA helicase which plays an important role in the DNA damage response. Several subsequent studies in independent patient cohorts have provided further data on …
In 2015, two independent studies provided initial evidence for a novel breast cancer susceptibility gene, RECQL, a DNA helicase which …
Analysis of a RECQL splicing mutation, c.1667_1667+3delAGTA, in breast cancer patients and controls from Central Europe.
Bogdanova N, Pfeifer K, Schürmann P, Antonenkova N, Siggelkow W, Christiansen H, Hillemanns P, Park-Simon TW, Dörk T. Bogdanova N, et al. Fam Cancer. 2017 Apr;16(2):181-186. doi: 10.1007/s10689-016-9944-y. Fam Cancer. 2017. PMID: 27832498
RECQL is a DNA helicase required for genomic stability. Two studies have recently identified RECQL as a novel breast cancer susceptibility gene. ...Further studies will be required to determine the clinical significance of testing for this RECQL mutation....
RECQL is a DNA helicase required for genomic stability. Two studies have recently identified RECQL as a novel breast cancer su …
The RECQL helicase prevents replication fork collapse during replication stress.
Benedict B, van Bueren MA, van Gemert FP, Lieftink C, Guerrero Llobet S, van Vugt MA, Beijersbergen RL, Te Riele H. Benedict B, et al. Life Sci Alliance. 2020 Aug 20;3(10):e202000668. doi: 10.26508/lsa.202000668. Print 2020 Oct. Life Sci Alliance. 2020. PMID: 32820027 Free PMC article.
To identify vulnerabilities of cells suffering from replication stress, we performed an shRNA-based genetic screen. We report that the RECQL helicase is specifically essential in replication stress conditions and protects stalled replication forks against MRE11-dependent d …
To identify vulnerabilities of cells suffering from replication stress, we performed an shRNA-based genetic screen. We report that the RE …
RECQL: a new breast cancer susceptibility gene.
Banerjee T, Brosh RM Jr. Banerjee T, et al. Cell Cycle. 2015;14(22):3540-3. doi: 10.1080/15384101.2015.1066539. Cell Cycle. 2015. PMID: 26125302 Free PMC article.
RECQL pathogenic mutations were identified that truncated or disrupted the RECQL protein or introduced missense mutations in its helicase domain. RECQL mutations may serve as a useful biomarker for breast cancer. Targeting RECQL associated tumors with …
RECQL pathogenic mutations were identified that truncated or disrupted the RECQL protein or introduced missense mutations in i …
High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival.
Mahmoodi A, Shoqafi A, Sun P, Giannakeas V, Cybulski C, Nofech-Mozes S, Masson JY, Sharma S, Samani AA, Madhusudan S, Narod SA, Akbari MR. Mahmoodi A, et al. Front Oncol. 2022 May 31;12:877617. doi: 10.3389/fonc.2022.877617. eCollection 2022. Front Oncol. 2022. PMID: 35712517 Free PMC article.
BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported. ...CONCLUSION: RECQL might …
BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high leve …
Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers.
Lashen A, Al-Kawaz A, Jeyapalan JN, Alqahtani S, Shoqafi A, Algethami M, Toss M, Green AR, Mongan NP, Sharma S, Akbari MR, Rakha EA, Madhusudan S. Lashen A, et al. Neoplasia. 2024 Jan;47:100957. doi: 10.1016/j.neo.2023.100957. Epub 2023 Dec 21. Neoplasia. 2024. PMID: 38134458 Free PMC article.
In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. Tumor mutation burden (TMB) was evaluated in five RECQL germ-line mutation carriers with IBC by genome sequencing. ...In germline …
In 726 IBCs, CD8+, FOXP3+, IL17+, PDL1+, PD1+ T-cell infiltration (TILs) were investigated in RECQL deficient and proficient cancers. …
RECQL: a DNA helicase in breast cancer.
Akbari MR, Cybulski C. Akbari MR, et al. Oncotarget. 2015 Sep 29;6(29):26558-9. doi: 10.18632/oncotarget.5452. Oncotarget. 2015. PMID: 26387136 Free PMC article. No abstract available.
Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers.
Liu NN, Song ZY, Guo HL, Yin H, Chen WF, Dai YX, Xin BG, Ai X, Ji L, Wang QM, Hou XM, Dou SX, Rety S, Xi XG. Liu NN, et al. Cell Rep. 2021 Sep 7;36(10):109688. doi: 10.1016/j.celrep.2021.109688. Cell Rep. 2021. PMID: 34496242 Free article.
We show here that, in contrast to current models, monomeric RECQL helicase is more abundant than oligomer/dimer forms in living cells. Further characterization of endogenous BtRECQL and isolated monomeric BtRECQL using various approaches demonstrates that both endogenous a …
We show here that, in contrast to current models, monomeric RECQL helicase is more abundant than oligomer/dimer forms in living cells …
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.
Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM Jr, Blackshear PJ. Sharma S, et al. Mol Cell Biol. 2007 Mar;27(5):1784-94. doi: 10.1128/MCB.01620-06. Epub 2006 Dec 11. Mol Cell Biol. 2007. PMID: 17158923 Free PMC article.
To date, no human disease has been associated with mutations in RECQL and no cellular phenotype has been associated with its deficiency. To gain insight into the physiological function of RECQL, we disrupted Recql in mice. RECQL-deficient mice did not …
To date, no human disease has been associated with mutations in RECQL and no cellular phenotype has been associated with its deficien …
240 results