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3,513 results

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Page 1
ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.
Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De León LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC. Arabzade A, et al. Cancer Discov. 2021 Sep;11(9):2200-2215. doi: 10.1158/2159-8290.CD-20-1066. Epub 2021 Mar 19. Cancer Discov. 2021. PMID: 33741710 Free PMC article.
More than 60% of supratentorial ependymomas harbor a ZFTA-RELA (ZR(fus)) gene fusion (formerly C11orf95-RELA). To study the biology of ZR(fus), we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. ...Our …
More than 60% of supratentorial ependymomas harbor a ZFTA-RELA (ZR(fus)) gene fusion (formerly C11orf95-RELA). To study the bi …
Negative regulation of RelA phosphorylation: emerging players and their roles in cancer.
Lu X, Yarbrough WG. Lu X, et al. Cytokine Growth Factor Rev. 2015 Feb;26(1):7-13. doi: 10.1016/j.cytogfr.2014.09.003. Epub 2014 Oct 2. Cytokine Growth Factor Rev. 2015. PMID: 25438737 Review.
NF-kappaB signaling contributes to human disease processes, notably inflammatory diseases and cancer. Many advances have been made in understanding mechanisms responsible for abnormal NF-kappaB activation with RelA post-translational modification, particularly phosp …
NF-kappaB signaling contributes to human disease processes, notably inflammatory diseases and cancer. Many advances have been made in …
Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-kappaB Activation and PD-L1 Expression.
Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, Ye Z, Ma T, Wu Q, Rodrigues DN, Kohli M, Jimenez R, Wang L, Goodrich DW, de Bono J, Dong H, Wu H, Zhu R, Huang H. Jin X, et al. Mol Cell. 2019 Jan 3;73(1):22-35.e6. doi: 10.1016/j.molcel.2018.10.034. Epub 2018 Dec 6. Mol Cell. 2019. PMID: 30527665 Free PMC article.
Aberrant expression of programmed death ligand-1 (PD-L1) in tumor cells promotes cancer progression by suppressing cancer immunity. The retinoblastoma protein RB is a tumor suppressor known to regulate the cell cycle, DNA damage response, and differentiation. ...Our …
Aberrant expression of programmed death ligand-1 (PD-L1) in tumor cells promotes cancer progression by suppressing cancer immu …
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
Nakazato A, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Fujii K, Saijoh S, Morita S, Yamazaki T, Imai T, Sato I, Satoh K, Yamaguchi K, Sugamura K, Yasuda J, Matsuura K, Shojaku H, Asada Y, Tamai K. Nakazato A, et al. Sci Rep. 2022 Oct 22;12(1):17751. doi: 10.1038/s41598-022-22736-6. Sci Rep. 2022. PMID: 36273237 Free PMC article.
In this study, we screened transcription factors and found that RELA (p65), a subunit of nuclear factor kappaB (NF-kappaB), is critical for CD271 transcription in cancer cells. ...These data suggested that RELA increases CD271 expression and that inhibition o …
In this study, we screened transcription factors and found that RELA (p65), a subunit of nuclear factor kappaB (NF-kappaB), is critic …
Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells.
Tang GX, Li ML, Zhou C, Huang ZS, Chen SB, Chen XC, Tan JH. Tang GX, et al. Cell Chem Biol. 2024 Oct 17;31(10):1800-1814.e7. doi: 10.1016/j.chembiol.2024.05.003. Epub 2024 May 30. Cell Chem Biol. 2024. PMID: 38821064
Using a chemical-genetic screening strategy, we demonstrated that the JAK/STAT3 pathway is the primary regulatory mechanism governing mtDNA G4 dynamics in hypoxic cancer cells. Further proteomic analysis showed that activation of the JAK/STAT3 pathway facilitates the trans …
Using a chemical-genetic screening strategy, we demonstrated that the JAK/STAT3 pathway is the primary regulatory mechanism governing mtDNA …
NFkappaB (RelA) mediates transactivation of hnRNPD in oral cancer cells.
Kumar V, Kumar A, Kumar M, Lone MR, Mishra D, Chauhan SS. Kumar V, et al. Sci Rep. 2022 Apr 8;12(1):5944. doi: 10.1038/s41598-022-09963-7. Sci Rep. 2022. PMID: 35396527 Free PMC article.
Finally, the expression of hnRNPD and NFkappaB in clinical specimen from 37 oral cancer patients was assessed and subjected to Spearmen's Correlation analysis which revealed a strong positive correlation between the two. Thus, results of the present study for the first tim …
Finally, the expression of hnRNPD and NFkappaB in clinical specimen from 37 oral cancer patients was assessed and subjected to Spearm …
NF-kappaB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer.
Geismann C, Hauser C, Grohmann F, Schneeweis C, Bölter N, Gundlach JP, Schneider G, Röcken C, Meinhardt C, Schäfer H, Schreiber S, Arlt A. Geismann C, et al. Cell Death Dis. 2023 Jan 3;14(1):3. doi: 10.1038/s41419-022-05535-9. Cell Death Dis. 2023. PMID: 36596765 Free PMC article.
In this context, A20 was identified as an NF-kappaB/RelA inducible target gene. Translational PDAC tissue analysis confirmed the correlation of elevated A20 protein expression with activated RelA expression in PDAC patients. ...
In this context, A20 was identified as an NF-kappaB/RelA inducible target gene. Translational PDAC tissue analysis confirmed the corr …
Histone variant H2AZ1 drives lung cancer progression through the RELA-HIF1A-EGFR signaling pathway.
Zhao H, Wu X, Wang Y, Li X, Du Y, Zhou Z, Li Y, Liu Y, Zeng X, Chen G. Zhao H, et al. Cell Commun Signal. 2024 Sep 26;22(1):453. doi: 10.1186/s12964-024-01823-3. Cell Commun Signal. 2024. PMID: 39327549 Free PMC article.
BACKGROUND: A growing body of evidence indicates that histone variants play an oncogenic role in cancer progression. However, the role and mechanism of histone variant H2AZ1 in lung cancer remain poorly understood. ...Importantly, we uncovered that H2AZ1 may drive l …
BACKGROUND: A growing body of evidence indicates that histone variants play an oncogenic role in cancer progression. However, the rol …
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development.
Wang X, Liu R, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G, Yang W. Wang X, et al. Mol Cell. 2019 Oct 3;76(1):148-162.e7. doi: 10.1016/j.molcel.2019.07.007. Epub 2019 Aug 22. Mol Cell. 2019. PMID: 31447391 Free article.
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Cancer cells often rewire their metabolic pathways for adaption to nutrient stress, and the underlying mechanism remains largely unknown. . …
The rapid proliferation of cancer cells and dysregulated vasculature within the tumor leads to limited nutrient accessibility. Can …
MLL2 promotes cancer cell lymph node metastasis by interacting with RelA and facilitating STC1 transcription.
Li H, Li Q, Lian J, Chu Y, Fang K, Xu A, Chen T, Xu M. Li H, et al. Cell Signal. 2020 Jan;65:109457. doi: 10.1016/j.cellsig.2019.109457. Epub 2019 Oct 30. Cell Signal. 2020. PMID: 31676369
MLL2 interacts with RelA in the nucleus to enhance transcription of stanniocalcin-1 (STC1) and to facilitate cancer metastasis. ...In summary, these findings discovered a previously unidentified molecular pathway underlying the coordinated regulation of metastasis-r …
MLL2 interacts with RelA in the nucleus to enhance transcription of stanniocalcin-1 (STC1) and to facilitate cancer metastasis …
3,513 results