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1963 8
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1,865 results

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Page 1
The risks of RELN polymorphisms and its expression in the development of otosclerosis.
Priyadarshi S, Hansdah K, Singh N, Bouzid A, Ray CS, Panda KC, Biswal NC, Desai A, Choudhury JC, Tekari A, Masmoudi S, Ramchander PV. Priyadarshi S, et al. PLoS One. 2022 Jun 3;17(6):e0269558. doi: 10.1371/journal.pone.0269558. eCollection 2022. PLoS One. 2022. PMID: 35658052 Free PMC article.
To understand the role of RELN and its receptors in the development of OTSC, we went further to perform a functional analysis of RELN/reelin. Here we detected a reduced RELN (p = 0.0068) and VLDLR (p = 0.0348) mRNA levels in the otosclerotic stapes tissues. . …
To understand the role of RELN and its receptors in the development of OTSC, we went further to perform a functional analysis of R …
Meta-analyses of RELN variants in neuropsychiatric disorders.
Chen N, Bao Y, Xue Y, Sun Y, Hu D, Meng S, Lu L, Shi J. Chen N, et al. Behav Brain Res. 2017 Aug 14;332:110-119. doi: 10.1016/j.bbr.2017.05.028. Epub 2017 May 12. Behav Brain Res. 2017. PMID: 28506622 Review.
Here, we conducted meta-analyses of RELN gene SNPs and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders). A total of 12 SNPs (rs736707, rs362691, rs607755, rs …
Here, we conducted meta-analyses of RELN gene SNPs and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders …
Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders.
Di Donato N, Guerrini R, Billington CJ, Barkovich AJ, Dinkel P, Freri E, Heide M, Gershon ES, Gertler TS, Hopkin RJ, Jacob S, Keedy SK, Kooshavar D, Lockhart PJ, Lohmann DR, Mahmoud IG, Parrini E, Schrock E, Severi G, Timms AE, Webster RI, Willis MJH, Zaki MS, Gleeson JG, Leventer RJ, Dobyns WB. Di Donato N, et al. Brain. 2022 Sep 14;145(9):3274-3287. doi: 10.1093/brain/awac164. Brain. 2022. PMID: 35769015 Free PMC article.
Despite the large size of the gene, only 11 individuals with RELN-related lissencephaly with cerebellar hypoplasia from six families have previously been reported. ...Reduced RELN secretion in heterozygous individuals affects only cortical structure whereas the cere …
Despite the large size of the gene, only 11 individuals with RELN-related lissencephaly with cerebellar hypoplasia from six families …
RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females.
Yamaguchi R, Matsudaira I, Takeuchi H, Imanishi T, Kimura R, Tomita H, Kawashima R, Taki Y. Yamaguchi R, et al. Neuroscience. 2022 Jul 1;494:38-50. doi: 10.1016/j.neuroscience.2022.05.007. Epub 2022 May 13. Neuroscience. 2022. PMID: 35569645
Although temperament has been regarded as an innate aspect of human personality, its association with proteins involved in embryonic development is unclear. Reelin, encoded by RELN, plays an important role in brain development. Herein, we investigated the association betwe …
Although temperament has been regarded as an innate aspect of human personality, its association with proteins involved in embryonic develop …
Lymphoangiocrine signals promote cardiac growth and repair.
Liu X, De la Cruz E, Gu X, Balint L, Oxendine-Burns M, Terrones T, Ma W, Kuo HH, Lantz C, Bansal T, Thorp E, Burridge P, Jakus Z, Herz J, Cleaver O, Torres M, Oliver G. Liu X, et al. Nature. 2020 Dec;588(7839):705-711. doi: 10.1038/s41586-020-2998-x. Epub 2020 Dec 9. Nature. 2020. PMID: 33299187 Free PMC article.
Characterization of the LEC secretome identified the extracellular protein reelin (RELN) as a key component of this process. Moreover, we report that LEC-specific Reln-null mouse embryos develop smaller hearts, that RELN is required for efficient heart repair …
Characterization of the LEC secretome identified the extracellular protein reelin (RELN) as a key component of this process. Moreover …
RELN rare variants in myoclonus-dystonia.
Groen JL, Ritz K, Jalalzadeh H, van der Salm SM, Jongejan A, Mook OR, Haagmans MA, Zwinderman AH, Motazacker MM, Hennekam RC, Baas F, Tijssen MA. Groen JL, et al. Mov Disord. 2015 Mar;30(3):415-9. doi: 10.1002/mds.26070. Epub 2015 Feb 4. Mov Disord. 2015. PMID: 25648840
RESULTS: We found co-segregation of the rare missense variant Thr1904Met in the RELN gene. By additional screening of an M-D cohort, we identified co-segregation of RELN variants in two families (Thr1904Met, Ile1217Met) and identified two sporadic RELN mutati …
RESULTS: We found co-segregation of the rare missense variant Thr1904Met in the RELN gene. By additional screening of an M-D cohort, …
RELN signaling modulates glioblastoma growth and substrate-dependent migration.
Schulze M, Violonchi C, Swoboda S, Welz T, Kerkhoff E, Hoja S, Brüggemann S, Simbürger J, Reinders J, Riemenschneider MJ. Schulze M, et al. Brain Pathol. 2018 Sep;28(5):695-709. doi: 10.1111/bpa.12584. Epub 2018 Jan 10. Brain Pathol. 2018. PMID: 29222813 Free PMC article.
RELN silencing occurs via promoter hypermethylation as shown by both database mining and bisulfite sequencing of the RELN promoter. ...Moreover, stimulation of RELN signaling strongly reduced proliferation in glioblastoma cells. This phenotype depends on DAB1 …
RELN silencing occurs via promoter hypermethylation as shown by both database mining and bisulfite sequencing of the RELN prom …
Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks.
Liao J, Dong G, Wulaer B, Sawahata M, Mizoguchi H, Mori D, Ozaki N, Nabeshima T, Nagai T, Yamada K. Liao J, et al. Behav Brain Res. 2022 Jan 7;416:113569. doi: 10.1016/j.bbr.2021.113569. Epub 2021 Sep 6. Behav Brain Res. 2022. PMID: 34499931 Free article.
The Reelin gene (RELN) encodes a large extracellular protein, which has multiple roles in brain development and adult brain function. It activates a series of neuronal signal transduction pathways in the adult brain that function in synaptic plasticity, dendritic morpholog …
The Reelin gene (RELN) encodes a large extracellular protein, which has multiple roles in brain development and adult brain function. …
Exome sequencing in four families with neurodevelopmental disorders: genotype-phenotype correlation and identification of novel disease-causing variants in VPS13B and RELN.
Afridi TUK, Fatima A, Satti HS, Akram Z, Yousafzai IK, Naeem WB, Fatima N, Ali A, Iqbal Z, Khan A, Shahzad M, Liu C, Toft M, Zhang F, Tariq M, Davis EE, Khan TN. Afridi TUK, et al. Mol Genet Genomics. 2024 May 21;299(1):55. doi: 10.1007/s00438-024-02149-y. Mol Genet Genomics. 2024. PMID: 38771357
Using exome sequencing (ES) as a diagnostic approach, we identified disease-causing variants in established NDD-associated genes in all families, including one hitherto unreported variant in RELN and three recurrent variants in VPS13B, DEGS1, and SPG11. Overall, our study …
Using exome sequencing (ES) as a diagnostic approach, we identified disease-causing variants in established NDD-associated genes in all fami …
Association between RELN polymorphisms and schizophrenia in a Han population from Northeast China.
Bai W, Fu Y, Yu X, Zhu B, Duan R, Yu Y, Kou C. Bai W, et al. Psychiatr Genet. 2019 Dec;29(6):232-236. doi: 10.1097/YPG.0000000000000235. Psychiatr Genet. 2019. PMID: 31469785
OBJECTIVE: To explore the association between the RELN gene and schizophrenia in the overall sample and samples stratified by sex in a northeastern Chinese population. ...The association between schizophrenia and RELN single-nucleotide polymorphisms was not found in …
OBJECTIVE: To explore the association between the RELN gene and schizophrenia in the overall sample and samples stratified by sex in …
1,865 results