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Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab).
Tam CS, O'Brien S, Plunkett W, Wierda W, Ferrajoli A, Wang X, Do KA, Cortes J, Khouri I, Kantarjian H, Lerner S, Keating MJ. Tam CS, et al. Blood. 2014 Nov 13;124(20):3059-64. doi: 10.1182/blood-2014-06-583765. Epub 2014 Oct 3. Blood. 2014. PMID: 25281606 Free PMC article.
After a median 142 months of follow-up, 156 patients developed progressive CLL, with a median survival of 51 months after disease progression. The duration of first remission (REM1) was a key determinant of survival after disease progression and first salvage. Patients wit …
After a median 142 months of follow-up, 156 patients developed progressive CLL, with a median survival of 51 months after disease progressio …
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.
Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith MJ. Dhanaraman T, et al. Sci Signal. 2020 Oct 13;13(653):eabb4778. doi: 10.1126/scisignal.abb4778. Sci Signal. 2020. PMID: 33051258
We demonstrated that the tumor suppressor RASSF1A formed complexes with the RAS-related GTPases GEM, REM1, REM2, and the enigmatic RASL12. Furthermore, interactions between RASSFs and RAS GTPases blocked YAP1 nuclear localization. ...
We demonstrated that the tumor suppressor RASSF1A formed complexes with the RAS-related GTPases GEM, REM1, REM2, and the enigmatic RA …
Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission.
Petersen FB, Lynch MH, Clift RA, Appelbaum FR, Sanders JE, Bensinger WI, Benyunes MC, Doney K, Fefer A, Martin P, et al. Petersen FB, et al. J Clin Oncol. 1993 Jul;11(7):1353-60. doi: 10.1200/JCO.1993.11.7.1353. J Clin Oncol. 1993. PMID: 8315433 Clinical Trial.
All REL1 patients and four REM2 patients had marrow stored during first remission (REM1). Twenty-seven had marrow stored with and 20 without treatment in vitro with 4-hydroperoxycyclophosphamide (4-HC). ...There is no apparent clinical advantage in attempting to obtain sec …
All REL1 patients and four REM2 patients had marrow stored during first remission (REM1). Twenty-seven had marrow stored with and 20 …
Mapping and characterization of a retinoic acid-responsive enhancer of midkine, a novel heparin-binding growth/differentiation factor with neurotrophic activity.
Matsubara S, Take M, Pedraza C, Muramatsu T. Matsubara S, et al. J Biochem. 1994 Jun;115(6):1088-96. doi: 10.1093/oxfordjournals.jbchem.a124462. J Biochem. 1994. PMID: 7982887 Free article.
Analysis of this region by deletion mutagenesis in F9 EC cells shows that there is a retinoic acid-responsive enhancer (designated as REM1) around 900 bp upstream from the transcription start site. This enhancer is composed of two sequence elements, which are located betwe …
Analysis of this region by deletion mutagenesis in F9 EC cells shows that there is a retinoic acid-responsive enhancer (designated as REM …