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Photoinstability of some tyrphostin drugs: chemical consequences of crystallinity.
Kumar N, Windisch V, Ammon HL. Kumar N, et al. Among authors: ammon hl. Pharm Res. 1995 Nov;12(11):1708-15. doi: 10.1023/a:1016213721861. Pharm Res. 1995. PMID: 8592674
PURPOSE: The purpose of this work was to study the photostability of the antiproliferative tyrphostin drug compounds RG 13022(I) and RG 14620(II) as a part of preformulation program. ...The photocycloaddition product of RG 14620, however, was found to involve …
PURPOSE: The purpose of this work was to study the photostability of the antiproliferative tyrphostin drug compounds RG 13022(I) and …
Structure of RG-12561 dichloromethane solvate and a diastereomer.
Ammon HL, Prasad SM, Kumar N. Ammon HL, et al. Acta Crystallogr C. 1992 Apr 15;48 ( Pt 4):669-75. doi: 10.1107/s0108270191010077. Acta Crystallogr C. 1992. PMID: 1515102
(III): [4 alpha,6 beta(E)]-(+-)-6-(2-[2-(4-Fluoro-3-methylphenyl)- 4,4,6,6-tetramethyl-1-cyclohexen-1-yl]ethenyl)-4-hydroxytetrahy dro pyran-2-one (RG-12561) dichloromethane solvate, 2C24H31FO3.CH2-Cl2, Mr = 857.94, triclinic, Pl, a = 11.7413 (5), b = 13.0279 (5), c = 16.2 …
(III): [4 alpha,6 beta(E)]-(+-)-6-(2-[2-(4-Fluoro-3-methylphenyl)- 4,4,6,6-tetramethyl-1-cyclohexen-1-yl]ethenyl)-4-hydroxytetrahy dro pyran …