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4,081 results

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Page 1
Challenges in Therapeutically Targeting the RNA-Recognition Motif.
Schmeing S, Hart P'. Schmeing S, et al. Wiley Interdiscip Rev RNA. 2024 Nov-Dec;15(6):e1877. doi: 10.1002/wrna.1877. Wiley Interdiscip Rev RNA. 2024. PMID: 39668490 Free PMC article. Review.
The RNA recognition motif (RRM) is the most common RNA binding domain found in the human proteome. RRM domains provide RNA-binding proteins with sequence specific RNA recognition allowing them to participate in RNA-centric p …
The RNA recognition motif (RRM) is the most common RNA binding domain found in the human proteome. RRM domains p …
The RNA-recognition motif in chloroplasts.
Ruwe H, Kupsch C, Teubner M, Schmitz-Linneweber C. Ruwe H, et al. J Plant Physiol. 2011 Aug 15;168(12):1361-71. doi: 10.1016/j.jplph.2011.01.012. Epub 2011 Feb 16. J Plant Physiol. 2011. PMID: 21330002 Review.
Chloroplast RNA metabolism is characterized by multiple RNA processing steps that require hundreds of RNA binding proteins. ...This review summarizes knowledge on chloroplast proteins that contain an RNA recognition motif, a classical …
Chloroplast RNA metabolism is characterized by multiple RNA processing steps that require hundreds of RNA binding prote …
Functional diversity of Arabidopsis organelle-localized RNA-recognition motif-containing proteins.
Shi X, Hanson MR, Bentolila S. Shi X, et al. Wiley Interdiscip Rev RNA. 2017 Sep;8(5). doi: 10.1002/wrna.1420. Epub 2017 Mar 29. Wiley Interdiscip Rev RNA. 2017. PMID: 28371504 Review.
RNA-Binding Proteins (RBPs) play key roles in plant gene expression and regulation. RBPs contain a variety of RNA-binding motifs, the most abundant and most widespread one in eukaryotes is the RNA recognition motif (RRM). ...Members of the Organ …
RNA-Binding Proteins (RBPs) play key roles in plant gene expression and regulation. RBPs contain a variety of RNA-binding moti …
RNA-Binding Peptides Inspired by the RNA Recognition Motif.
Marshall LK, Fahrenbach AC, Thordarson P. Marshall LK, et al. ACS Chem Biol. 2024 Feb 16;19(2):243-248. doi: 10.1021/acschembio.3c00694. Epub 2024 Feb 5. ACS Chem Biol. 2024. PMID: 38314708
beta-Hairpin peptides with RNA-binding sequences mimicking the central two beta-strands of the RNA recognition motif (RRM) protein domain have been observed to bind in a 2:1 fashion to a series of RNA homooligonucleotides in aqueous solution (PB …
beta-Hairpin peptides with RNA-binding sequences mimicking the central two beta-strands of the RNA recognition motif …
The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression.
Maris C, Dominguez C, Allain FH. Maris C, et al. FEBS J. 2005 May;272(9):2118-31. doi: 10.1111/j.1742-4658.2005.04653.x. FEBS J. 2005. PMID: 15853797 Free article. Review.
The RNA recognition motif (RRM), also known as RNA-binding domain (RBD) or ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes. Based on the comparison of more than 40 structures including 15 complexes (RRM-RNA …
The RNA recognition motif (RRM), also known as RNA-binding domain (RBD) or ribonucleoprotein domain (RNP) is one …
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y. Yang C, et al. Autophagy. 2023 Jul;19(7):1934-1951. doi: 10.1080/15548627.2022.2164427. Epub 2023 Jan 24. Autophagy. 2023. PMID: 36692217 Free PMC article.
Here, we screened six E3 ubiquitin ligases present in SGs and identified TRIM21 (tripartite motif containing 21) as a central regulator of SG homeostasis that is highly enriched in SGs of cells under arsenite-induced oxidative stress. ...Collectively, our study broadens th …
Here, we screened six E3 ubiquitin ligases present in SGs and identified TRIM21 (tripartite motif containing 21) as a central regulat …
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP. Gwon Y, et al. Science. 2021 Jun 25;372(6549):eabf6548. doi: 10.1126/science.abf6548. Epub 2021 Aug 5. Science. 2021. PMID: 34739333 Free PMC article.
Stress granules are dynamic, reversible condensates composed of RNA and protein that assemble in eukaryotic cells in response to a variety of stressors and are normally disassembled after stress is removed. ...Using cultured human cells, we found that stress granule disass …
Stress granules are dynamic, reversible condensates composed of RNA and protein that assemble in eukaryotic cells in response to a va …
Sequence, Structure, and Context Preferences of Human RNA Binding Proteins.
Dominguez D, Freese P, Alexis MS, Su A, Hochman M, Palden T, Bazile C, Lambert NJ, Van Nostrand EL, Pratt GA, Yeo GW, Graveley BR, Burge CB. Dominguez D, et al. Mol Cell. 2018 Jun 7;70(5):854-867.e9. doi: 10.1016/j.molcel.2018.05.001. Epub 2018 Jun 7. Mol Cell. 2018. PMID: 29883606 Free PMC article.
RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. ...Our results emphasize the importance of contextual features in RNA recognition, which likely enable targeting of distinct subsets of transcripts by different RBPs th …
RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. ...Our results emphasize the importance of …
Structural basis of UCUU RNA motif recognition by splicing factor RBM20.
Upadhyay SK, Mackereth CD. Upadhyay SK, et al. Nucleic Acids Res. 2020 May 7;48(8):4538-4550. doi: 10.1093/nar/gkaa168. Nucleic Acids Res. 2020. PMID: 32187365 Free PMC article.
Previous studies have identified the four nucleotide RNA motif UCUU as a common element in pre-mRNA targeted by RBM20. Here, we have determined the structure of the RNA Recognition Motif (RRM) domain from mouse RBM20 bound to RNA containi …
Previous studies have identified the four nucleotide RNA motif UCUU as a common element in pre-mRNA targeted by RBM20. Here, w …
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J. Zhao Z, et al. Cell. 2023 Jul 20;186(15):3208-3226.e27. doi: 10.1016/j.cell.2023.05.047. Epub 2023 Jun 27. Cell. 2023. PMID: 37379838 Free PMC article.
By transcriptome-wide profiling/mapping of internal m(7)G methylome and QKI-binding sites, we identified more than 1,000 high-confidence m(7)G-modified and QKI-bound mRNA targets with a conserved "GANGAN (N = A/C/U/G)" motif. Strikingly, QKI7 interacts (via C terminus) wit …
By transcriptome-wide profiling/mapping of internal m(7)G methylome and QKI-binding sites, we identified more than 1,000 high-confidence m(7 …
4,081 results