Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1971 1
1972 1
1973 1
1974 4
1975 6
1976 1
1977 4
1978 4
1979 3
1980 2
1981 2
1982 1
1983 1
1985 2
1987 1
1988 4
1989 3
1990 10
1991 8
1992 2
1993 6
1994 6
1995 10
1996 8
1997 9
1998 12
1999 10
2000 8
2001 5
2002 4
2003 8
2004 7
2005 4
2006 6
2007 4
2008 10
2009 8
2010 11
2011 6
2012 8
2013 8
2014 8
2015 9
2016 6
2017 14
2018 9
2019 13
2020 8
2021 12
2022 8
2023 6
2024 7
2025 5
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

313 results

Results by year

Filters applied: . Clear all
Page 1
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Uhl L, Aziba A, Löbbert S, Russell T, Krenz B, Montesinos F, Kannan T, Valanju OR, Schülein-Völk C, de Martines T, Bolz M, Fleischhauer D, Cossa G, Endres T, Solvie D, Gallant P, Rosenwald A, Maric HM, Papadopoulos D, Vos SM, Eilers M. Uhl L, et al. Cell. 2026 Mar 5;189(5):1371-1388.e29. doi: 10.1016/j.cell.2025.12.019. Epub 2026 Jan 22. Cell. 2026. PMID: 41576951 Free article.
Via RBRIII, MYC suppresses the accumulation of R-loop-derived RNA-DNA hybrids and prevents them from activating the innate immune kinase TBK1 via the TLR3 pattern recognition receptor. Our data demonstrate that the phase transition of MYC is an RNA-dri …
Via RBRIII, MYC suppresses the accumulation of R-loop-derived RNA-DNA hybrids and prevents them from activating …
RNA-DNA hybrid binding domain broadens the editing window of base editors.
Yang Y, Fu Z, Deng S, Wu G, Wang C, Luo X, Kang R, Chen Y, Peng C, Zhang P, Cui K, Wan F, Wang J, Zhou Q, Chen W, Xiong Y, Ma W, Songyang Z, Liang P. Yang Y, et al. Mol Ther. 2025 Sep 3;33(9):4431-4446. doi: 10.1016/j.ymthe.2025.06.024. Epub 2025 Jun 14. Mol Ther. 2025. PMID: 40518666
Adenine base editors (ABEs) and cytosine base editors (CBEs) are prominent tools for precise genome editing but are hindered by limited editing activity at positions proximal to the protospacer adjacent motif (PAM). This study investigates the potential of enhancing base e …
Adenine base editors (ABEs) and cytosine base editors (CBEs) are prominent tools for precise genome editing but are hindered by limited edit …
Viral reverse transcriptases.
Menéndez-Arias L, Sebastián-Martín A, Álvarez M. Menéndez-Arias L, et al. Virus Res. 2017 Apr 15;234:153-176. doi: 10.1016/j.virusres.2016.12.019. Epub 2016 Dec 30. Virus Res. 2017. PMID: 28043823 Free article. Review.
RTs are enzymes that are able to synthesize DNA using RNA or DNA as templates (DNA polymerase activity), and degrade RNA when forming RNA/DNA hybrids (ribonuclease H activity). In retroviruses and LTR retrotransposons (Metaviridae and Pse …
RTs are enzymes that are able to synthesize DNA using RNA or DNA as templates (DNA polymerase activity), and degrade RNA when forming …
Chimeric RNA-DNA molecular beacon assay for ribonuclease H activity.
Rizzo J, Gifford LK, Zhang X, Gewirtz AM, Lu P. Rizzo J, et al. Mol Cell Probes. 2002 Aug;16(4):277-83. doi: 10.1006/mcpr.2002.0423. Mol Cell Probes. 2002. PMID: 12270269
Current methods to detect and assay ribonuclease H (RNase H) activity are indirect and time-consuming. Here we introduce a direct and sensitive method, based on the fluorescence quenching mechanism of molecular beacons, to assay RNA cleavage in RNA:DNA …
Current methods to detect and assay ribonuclease H (RNase H) activity are indirect and time-consuming. Here we introduce a dir …
Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps.
Jia X, Li Y, Wang T, Bi L, Guo L, Chen Z, Zhang X, Ye S, Chen J, Yang B, Sun B. Jia X, et al. EMBO J. 2023 Jan 4;42(1):e111703. doi: 10.15252/embj.2022111703. Epub 2022 Nov 3. EMBO J. 2023. PMID: 36326837 Free PMC article.
It thus serves as a model system for investigating the similarities and discrepancies between exoribonuclease and exodeoxyribonuclease activities and for understanding the nucleic acid (NA) unwinding-degradation coordination of an exonuclease. Here, using a s …
It thus serves as a model system for investigating the similarities and discrepancies between exoribonuclease and exodeoxyribonuclease ac …
Identification of the ternary complex of ribonuclease HI:RNA/DNA hybrid:metal ions by ESI mass spectrometry.
Ando T, Jongruja N, Okumura N, Morikawa K, Kanaya S, Takao T. Ando T, et al. J Biol Chem. 2021 Jan-Jun;296:100462. doi: 10.1016/j.jbc.2021.100462. Epub 2021 Feb 25. J Biol Chem. 2021. PMID: 33639158 Free PMC article.
Ribonuclease HI, an endoribonuclease, catalyzes the hydrolysis of the RNA strand of an RNA/DNA hybrid and requires divalent metal ions for its enzymatic activity. However, the mechanistic details of the activity of ribonuclease HI …
Ribonuclease HI, an endoribonuclease, catalyzes the hydrolysis of the RNA strand of an RNA/DNA hybrid and requir …
Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Nowotny M, et al. EMBO J. 2008 Apr 9;27(7):1172-81. doi: 10.1038/emboj.2008.44. Epub 2008 Mar 13. EMBO J. 2008. PMID: 18337749 Free PMC article.
Human RNase H1 contains an N-terminal domain known as dsRHbd for binding both dsRNA and RNA/DNA hybrid. We find that dsRHbd binds preferentially to RNA/DNA hybrids by over 25-fold and rename it as hybrid binding domain (HBD). ...Si …
Human RNase H1 contains an N-terminal domain known as dsRHbd for binding both dsRNA and RNA/DNA hybrid. We find that ds …
RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA-DNA hybrid cleavage.
Li Y, Liu C, Jia X, Bi L, Ren Z, Zhao Y, Zhang X, Guo L, Bao Y, Liu C, Li W, Sun B. Li Y, et al. Nat Commun. 2024 Aug 29;15(1):7464. doi: 10.1038/s41467-024-51984-5. Nat Commun. 2024. PMID: 39198528 Free PMC article.
RNase H1 has been acknowledged as an endoribonuclease specializing in the internal degradation of the RNA moiety within RNA-DNA hybrids, and its ribonuclease activity is indispensable in multifaceted aspects of nucleic acid metabol …
RNase H1 has been acknowledged as an endoribonuclease specializing in the internal degradation of the RNA moiety within RNA-DNA …
RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.
Cristini A, Tellier M, Constantinescu F, Accalai C, Albulescu LO, Heiringhoff R, Bery N, Sordet O, Murphy S, Gromak N. Cristini A, et al. Nat Commun. 2022 May 26;13(1):2961. doi: 10.1038/s41467-022-30604-0. Nat Commun. 2022. PMID: 35618715 Free PMC article.
RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutieres syndrome (AGS). ...RNase H2 depletion impairs transcription leading to accumulation of R-loops, st …
RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency of this enzyme causes a severe neu …
The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase.
Horton NC, Finzel BC. Horton NC, et al. J Mol Biol. 1996 Dec 6;264(3):521-33. doi: 10.1006/jmbi.1996.0658. J Mol Biol. 1996. PMID: 8969302
The global parameters rise and base-pairs tilt (or inclination) are like that of A-DNA, however the slide and x displacement (Dx) are more like that of A-RNA, thus giving the hybrid a unique conformation. In addition, the 10-mer crystallizes in a manner that allows the for …
The global parameters rise and base-pairs tilt (or inclination) are like that of A-DNA, however the slide and x displacement (Dx) are more l …
313 results