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Did you mean rocha j d a (3 results)?
Seminal Plasma: Relevant for Fertility?
Rodriguez-Martinez H, Martinez EA, Calvete JJ, Peña Vega FJ, Roca J. Rodriguez-Martinez H, et al. Among authors: roca j. Int J Mol Sci. 2021 Apr 22;22(9):4368. doi: 10.3390/ijms22094368. Int J Mol Sci. 2021. PMID: 33922047 Free PMC article. Review.
Its composition, despite species-specific anatomical peculiarities, consistently contains inorganic ions, specific hormones, proteins and peptides, including cytokines and enzymes, cholesterol, DNA and RNA-the latter often protected within epididymis- or prostate-derived e …
Its composition, despite species-specific anatomical peculiarities, consistently contains inorganic ions, specific hormones, proteins and pe …
The torsional state of DNA within the chromosome.
Roca J. Roca J. Chromosoma. 2011 Aug;120(4):323-34. doi: 10.1007/s00412-011-0324-y. Epub 2011 May 13. Chromosoma. 2011. PMID: 21567156 Review.
Yet, understanding how the torsional state of DNA is modulated remains a challenging task due to the multiplicity of cellular factors involved in the generation, transmission, and dissipation of DNA twisting forces. Here, an overview of the implication of DNA …
Yet, understanding how the torsional state of DNA is modulated remains a challenging task due to the multiplicity of cellular factors …
DNA knots occur in intracellular chromatin.
Valdés A, Segura J, Dyson S, Martínez-García B, Roca J. Valdés A, et al. Among authors: roca j. Nucleic Acids Res. 2018 Jan 25;46(2):650-660. doi: 10.1093/nar/gkx1137. Nucleic Acids Res. 2018. PMID: 29149297 Free PMC article.
Therefore, intra-molecular DNA entanglements (knots) might occur via DNA strand passage activity of topoisomerase II. ...These knots occur irrespective of DNA replication and cell proliferation, though their abundance is reduced during DNA transcriptio …
Therefore, intra-molecular DNA entanglements (knots) might occur via DNA strand passage activity of topoisomerase II. ...These …
Keeping intracellular DNA untangled: A new role for condensin?
Roca J, Dyson S, Segura J, Valdés A, Martínez-García B. Roca J, et al. Bioessays. 2022 Jan;44(1):e2100187. doi: 10.1002/bies.202100187. Epub 2021 Nov 10. Bioessays. 2022. PMID: 34761394
The DNA-passage activity of topoisomerase II accidentally produces DNA knots and interlinks within and between chromatin fibers. ...Second, DNA supercoiling could bias topoisomerase II to untangle the DNA. ...
The DNA-passage activity of topoisomerase II accidentally produces DNA knots and interlinks within and between chromatin fiber …
Electrophoretic Analysis of the DNA Supercoiling Activity of DNA Gyrase.
Martínez-García B, Valdés A, Segura J, Dyson S, Díaz-Ingelmo O, Roca J. Martínez-García B, et al. Among authors: roca j. Methods Mol Biol. 2018;1805:291-300. doi: 10.1007/978-1-4939-8556-2_15. Methods Mol Biol. 2018. PMID: 29971724
Most bacterial cells have a motor enzyme termed DNA gyrase, which is a type-2 topoisomerase that reduces the linking number (Lk) of DNA. ...Particular emphasis is made on the preparation of a relaxed plasmid as initial DNA substrate, on the distinction of con …
Most bacterial cells have a motor enzyme termed DNA gyrase, which is a type-2 topoisomerase that reduces the linking number (Lk) of …
Condensin minimizes topoisomerase II-mediated entanglements of DNA in vivo.
Dyson S, Segura J, Martínez-García B, Valdés A, Roca J. Dyson S, et al. Among authors: roca j. EMBO J. 2021 Jan 4;40(1):e105393. doi: 10.15252/embj.2020105393. Epub 2020 Nov 6. EMBO J. 2021. PMID: 33155682 Free PMC article.
The juxtaposition of intracellular DNA segments, together with the DNA-passage activity of topoisomerase II, leads to the formation of DNA knots and interlinks, which jeopardize chromatin structure and gene expression. Recent studies in budding yeast have sho …
The juxtaposition of intracellular DNA segments, together with the DNA-passage activity of topoisomerase II, leads to the form …
Topoisomerase II: a fitted mechanism for the chromatin landscape.
Roca J. Roca J. Nucleic Acids Res. 2009 Feb;37(3):721-30. doi: 10.1093/nar/gkn994. Epub 2008 Dec 5. Nucleic Acids Res. 2009. PMID: 19059997 Free PMC article. Review.
The mechanism by which type-2A topoisomerases transport one DNA duplex through a transient double-strand break produced in another exhibits fascinating traits. One of them is the fine coupling between inter-domainal movements and ATP usage; another is their preference to t …
The mechanism by which type-2A topoisomerases transport one DNA duplex through a transient double-strand break produced in another ex …
Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage.
Martínez-García B, Fernández X, Díaz-Ingelmo O, Rodríguez-Campos A, Manichanh C, Roca J. Martínez-García B, et al. Among authors: roca j. Nucleic Acids Res. 2014 Feb;42(3):1821-30. doi: 10.1093/nar/gkt1037. Epub 2013 Oct 31. Nucleic Acids Res. 2014. PMID: 24185700 Free PMC article.
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilib …
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fract …
Quantitative disclosure of DNA knot chirality by high-resolution 2D-gel electrophoresis.
Valdés A, Martínez-García B, Segura J, Dyson S, Díaz-Ingelmo O, Roca J. Valdés A, et al. Among authors: roca j. Nucleic Acids Res. 2019 Mar 18;47(5):e29. doi: 10.1093/nar/gkz015. Nucleic Acids Res. 2019. PMID: 30649468 Free PMC article.
Since knotting, like supercoiling, makes DNA molecules more compact, DNA knot probability and knot complexity can be assessed by the electrophoretic velocity of nicked DNA circles. However, the chirality of the DNA knots has to be determined by visuali …
Since knotting, like supercoiling, makes DNA molecules more compact, DNA knot probability and knot complexity can be assessed …
The mechanisms of DNA topoisomerases.
Roca J. Roca J. Trends Biochem Sci. 1995 Apr;20(4):156-60. doi: 10.1016/s0968-0004(00)88993-8. Trends Biochem Sci. 1995. PMID: 7770916 Review.
Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA …
Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzym …
82 results