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Did you mean rocha j d a (1 results)?
Transcriptional supercoiling boosts topoisomerase II-mediated knotting of intracellular DNA.
Valdés A, Coronel L, Martínez-García B, Segura J, Dyson S, Díaz-Ingelmo O, Micheletti C, Roca J. Valdés A, et al. Among authors: roca j. Nucleic Acids Res. 2019 Jul 26;47(13):6946-6955. doi: 10.1093/nar/gkz491. Nucleic Acids Res. 2019. PMID: 31165864 Free PMC article.
Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA supercoils and DNA replication intertwines, but also produces small amounts of DNA knots within the clusters of nucleosomes that conf …
Recent studies have revealed that the DNA cross-inversion mechanism of topoisomerase II (topo II) not only removes DNA superco …
DNA knots occur in intracellular chromatin.
Valdés A, Segura J, Dyson S, Martínez-García B, Roca J. Valdés A, et al. Among authors: roca j. Nucleic Acids Res. 2018 Jan 25;46(2):650-660. doi: 10.1093/nar/gkx1137. Nucleic Acids Res. 2018. PMID: 29149297 Free PMC article.
In vivo DNA molecules are narrowly folded within chromatin fibers and self-interacting chromatin domains. Therefore, intra-molecular DNA entanglements (knots) might occur via DNA strand passage activity of topoisomerase II. ...These knots occur irrespective o …
In vivo DNA molecules are narrowly folded within chromatin fibers and self-interacting chromatin domains. Therefore, intra-molecular …
Electrophoretic Analysis of the DNA Supercoiling Activity of DNA Gyrase.
Martínez-García B, Valdés A, Segura J, Dyson S, Díaz-Ingelmo O, Roca J. Martínez-García B, et al. Among authors: roca j. Methods Mol Biol. 2018;1805:291-300. doi: 10.1007/978-1-4939-8556-2_15. Methods Mol Biol. 2018. PMID: 29971724
Most bacterial cells have a motor enzyme termed DNA gyrase, which is a type-2 topoisomerase that reduces the linking number (Lk) of DNA. ...Particular emphasis is made on the preparation of a relaxed plasmid as initial DNA substrate, on the distinction of con …
Most bacterial cells have a motor enzyme termed DNA gyrase, which is a type-2 topoisomerase that reduces the linking number (Lk) of …
Quantitative disclosure of DNA knot chirality by high-resolution 2D-gel electrophoresis.
Valdés A, Martínez-García B, Segura J, Dyson S, Díaz-Ingelmo O, Roca J. Valdés A, et al. Among authors: roca j. Nucleic Acids Res. 2019 Mar 18;47(5):e29. doi: 10.1093/nar/gkz015. Nucleic Acids Res. 2019. PMID: 30649468 Free PMC article.
Since knotting, like supercoiling, makes DNA molecules more compact, DNA knot probability and knot complexity can be assessed by the electrophoretic velocity of nicked DNA circles. ...This development in DNA knot analysis may uncover valuable informati …
Since knotting, like supercoiling, makes DNA molecules more compact, DNA knot probability and knot complexity can be assessed …
Intracellular nucleosomes constrain a DNA linking number difference of -1.26 that reconciles the Lk paradox.
Segura J, Joshi RS, Díaz-Ingelmo O, Valdés A, Dyson S, Martínez-García B, Roca J. Segura J, et al. Among authors: roca j. Nat Commun. 2018 Sep 28;9(1):3989. doi: 10.1038/s41467-018-06547-w. Nat Commun. 2018. PMID: 30266901 Free PMC article.
The interplay between chromatin structure and DNA topology is a fundamental, yet elusive, regulator of genome activities. A paradigmatic case is the "linking number paradox" of nucleosomal DNA, which refers to the incongruence between the near two left-handed superh …
The interplay between chromatin structure and DNA topology is a fundamental, yet elusive, regulator of genome activities. A paradigma …
Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage.
Martínez-García B, Fernández X, Díaz-Ingelmo O, Rodríguez-Campos A, Manichanh C, Roca J. Martínez-García B, et al. Among authors: roca j. Nucleic Acids Res. 2014 Feb;42(3):1821-30. doi: 10.1093/nar/gkt1037. Epub 2013 Oct 31. Nucleic Acids Res. 2014. PMID: 24185700 Free PMC article.
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilib …
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fract …
The torsional state of DNA within the chromosome.
Roca J. Roca J. Chromosoma. 2011 Aug;120(4):323-34. doi: 10.1007/s00412-011-0324-y. Epub 2011 May 13. Chromosoma. 2011. PMID: 21567156 Review.
Yet, understanding how the torsional state of DNA is modulated remains a challenging task due to the multiplicity of cellular factors involved in the generation, transmission, and dissipation of DNA twisting forces. Here, an overview of the implication of DNA
Yet, understanding how the torsional state of DNA is modulated remains a challenging task due to the multiplicity of cellular factors …
Seminal plasma antioxidants are directly involved in boar sperm cryotolerance.
Li J, Barranco I, Tvarijonaviciute A, Molina MF, Martinez EA, Rodriguez-Martinez H, Parrilla I, Roca J. Li J, et al. Among authors: roca j. Theriogenology. 2018 Feb;107:27-35. doi: 10.1016/j.theriogenology.2017.10.035. Epub 2017 Oct 31. Theriogenology. 2018. PMID: 29128698 Free article.
The percentage of FT sperm exhibiting fragmented nuclear DNA did not differ among ejaculate fractions and the EE. Catalase, glutathione peroxidase and glutathione peroxidase 5 (GPx-5) were lowest in SP from the first 10 mL of the SRF (P < 0.001), whereas superoxide dism …
The percentage of FT sperm exhibiting fragmented nuclear DNA did not differ among ejaculate fractions and the EE. Catalase, glutathio …
Structure and Chromosomal Organization of Yeast Genes Regulated by Topoisomerase II.
Joshi RS, Nikolaou C, Roca J. Joshi RS, et al. Among authors: roca j. Int J Mol Sci. 2018 Jan 3;19(1):134. doi: 10.3390/ijms19010134. Int J Mol Sci. 2018. PMID: 29301361 Free PMC article. Review.
Cellular DNA topoisomerases (topo I and topo II) are highly conserved enzymes that regulate the topology of DNA during normal genome transactions, such as DNA transcription and replication. ...These short term responses also uncovered topo II regulation of tr …
Cellular DNA topoisomerases (topo I and topo II) are highly conserved enzymes that regulate the topology of DNA during normal …
Topoisomerase II: a fitted mechanism for the chromatin landscape.
Roca J. Roca J. Nucleic Acids Res. 2009 Feb;37(3):721-30. doi: 10.1093/nar/gkn994. Epub 2008 Dec 5. Nucleic Acids Res. 2009. PMID: 19059997 Free PMC article. Review.
These capabilities have been inferred from in vitro studies but we ignore their significance inside the cell, where DNA configurations markedly differ from those of DNA in free solution. ...Some aspects addressed are the importance of the DNA rejoining step t …
These capabilities have been inferred from in vitro studies but we ignore their significance inside the cell, where DNA configuration …
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