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2018 9
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The following term was not found in PubMed: RP170660
Page 1
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.
Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJ. Kim J, et al. Nat Metab. 2020 Dec;2(12):1401-1412. doi: 10.1038/s42255-020-00316-0. Epub 2020 Nov 30. Nat Metab. 2020. PMID: 33257855 Free PMC article.
In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumour suppressor STK11 (also known as LKB1) encoding the kinase LKB1 result in aggressive tumours prone to metastasis but with liabilities arising from reprogrammed metabolism. We pre …
In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumour suppressor STK11 (also known as LKB1) …
Subclonal heterogeneity and evolution in breast cancer.
Mavrommati I, Johnson F, Echeverria GV, Natrajan R. Mavrommati I, et al. NPJ Breast Cancer. 2021 Dec 21;7(1):155. doi: 10.1038/s41523-021-00363-0. NPJ Breast Cancer. 2021. PMID: 34934048 Free PMC article. Review.
Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progression and resistance to current therapies. In this review, we focus on the recent advances in understanding the epigenetic and transcriptomi …
Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progre …
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Lv D, et al. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. Nat Commun. 2021. PMID: 34824248 Free PMC article.
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond beta-catenin and the destruction complex.
Jung YS, Park JI. Jung YS, et al. Exp Mol Med. 2020 Feb;52(2):183-191. doi: 10.1038/s12276-020-0380-6. Epub 2020 Feb 10. Exp Mol Med. 2020. PMID: 32037398 Free PMC article. Review.
Wnt/beta-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/beta-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibit …
Wnt/beta-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration …
LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination.
Tsang SV, Rainusso N, Liu M, Nomura M, Patel TD, Nakahata K, Kim HR, Huang S, Rajapakshe K, Coarfa C, Man TK, Rao PH, Yustein JT. Tsang SV, et al. Oncogene. 2022 Dec;41(50):5373-5384. doi: 10.1038/s41388-022-02538-w. Epub 2022 Nov 8. Oncogene. 2022. PMID: 36348010
Altogether, this study elucidated a role for PVT-1 in the enhancement of cancer stem-like behaviors, including migration and invasion, in osteosarcoma, and identified the novel PVT-1/TRIM28 axis signaling cascade as a potential therapeutic target for osteosarcoma treatment …
Altogether, this study elucidated a role for PVT-1 in the enhancement of cancer stem-like behaviors, including migration and invasion …
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics.
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H, Kim BYS, Jiang W. Wang Y, et al. Nat Nanotechnol. 2024 Feb;19(2):255-263. doi: 10.1038/s41565-023-01502-3. Epub 2023 Sep 18. Nat Nanotechnol. 2024. PMID: 37723279
However, clinical adoption of nanoformulated agents is often hindered by concerns about hepatic uptake and clearance, a process that is not fully understood. Here we show that the antitumour efficacy of cancer nanomedicine exhibits an age-associated disparity. Tumour deliv …
However, clinical adoption of nanoformulated agents is often hindered by concerns about hepatic uptake and clearance, a process that is not …
Cell identity and plasticity uncoupled.
Di Stefano B. Di Stefano B. Nat Cell Biol. 2022 Sep;24(9):1326-1327. doi: 10.1038/s41556-022-00943-7. Nat Cell Biol. 2022. PMID: 36075977 No abstract available.
50 results