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30 results

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Page 1
Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.
Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW. Szwarc MM, et al. Sci Rep. 2018 Sep 3;8(1):13134. doi: 10.1038/s41598-018-31372-y. Sci Rep. 2018. PMID: 30177747 Free PMC article.
Levels of SRC-2 are elevated in endometrial biopsies from polycystic ovary syndrome patients, a population predisposed to endometrial cancer (EC). Increased expression of SRC-2 is also detected in neoplastic endometrium suggesting a causal link between elevated SRC-2 expre …
Levels of SRC-2 are elevated in endometrial biopsies from polycystic ovary syndrome patients, a population predisposed to endometrial can …
MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.
Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y, He X. Qiu Z, et al. Gastroenterology. 2015 Nov;149(6):1587-1598.e11. doi: 10.1053/j.gastro.2015.07.050. Epub 2015 Aug 3. Gastroenterology. 2015. PMID: 26248089
BACKGROUND & AIMS: Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNAs) have been associated with colorectal cancer (CRC) development and progression, but it is not clear whether they regulate metabolis …
BACKGROUND & AIMS: Cancer cells alter glucose metabolism to support their uncontrolled proliferation. Changes in microRNAs (miRNA …
Suppression of Ribose-5-Phosphate Isomerase a Induces ROS to Activate Autophagy, Apoptosis, and Cellular Senescence in Lung Cancer.
Nieh YC, Chou YT, Chou YT, Wang CY, Lin SX, Ciou SC, Yuh CH, Wang HD. Nieh YC, et al. Int J Mol Sci. 2022 Jul 17;23(14):7883. doi: 10.3390/ijms23147883. Int J Mol Sci. 2022. PMID: 35887232 Free PMC article.
Ribose-5-phosphate isomerase A (RPIA) regulates tumorigenesis in liver and colorectal cancer. However, the role of RPIA in lung cancer remains obscure. ...Our study sheds new light on RPIA suppression in lung cancer therapy....
Ribose-5-phosphate isomerase A (RPIA) regulates tumorigenesis in liver and colorectal cancer. However, the role of RPIA …
Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating beta-catenin via a novel C-terminal domain.
Chou YT, Jiang JK, Yang MH, Lu JW, Lin HK, Wang HD, Yuh CH. Chou YT, et al. PLoS Biol. 2018 Jan 16;16(1):e2003714. doi: 10.1371/journal.pbio.2003714. eCollection 2018 Jan. PLoS Biol. 2018. PMID: 29337987 Free PMC article.
Yet, the molecular mechanism of RPIA-mediated colorectal cancer (CRC) is unknown. Our study demonstrates a noncanonical function of RPIA in CRC. Data from the mRNAs of 80 patients' CRC tissues and paired nontumor tissues and protein levels, as well as a CRC t …
Yet, the molecular mechanism of RPIA-mediated colorectal cancer (CRC) is unknown. Our study demonstrates a noncanonical functi …
Cell Proliferation and Apoptosis-Key Players in the Lung Aging Process.
Ancer-Rodríguez J, Gopar-Cuevas Y, García-Aguilar K, Chávez-Briones MD, Miranda-Maldonado I, Ancer-Arellano A, Ortega-Martínez M, Jaramillo-Rangel G. Ancer-Rodríguez J, et al. Int J Mol Sci. 2024 Jul 18;25(14):7867. doi: 10.3390/ijms25147867. Int J Mol Sci. 2024. PMID: 39063108 Free PMC article. Review.
Changes that occur in the lung during aging increase the risk of developing acute and chronic lung diseases, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. During normal tissue homeostasis …
Changes that occur in the lung during aging increase the risk of developing acute and chronic lung diseases, such as acute respiratory distr …
Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and beta-catenin pathways.
Chou YT, Chen LY, Tsai SL, Tu HC, Lu JW, Ciou SC, Wang HD, Yuh CH. Chou YT, et al. Carcinogenesis. 2019 May 14;40(3):461-473. doi: 10.1093/carcin/bgy155. Carcinogenesis. 2019. PMID: 30418535 Free PMC article.
To further investigate RPIA-mediated hepatocarcinogenesis, two independent lines of transgenic zebrafish expressing human RPIA in the liver were generated. ...Our study presents a mechanism for RPIA-mediated hepatocarcinogenesis and suggests that RPIA …
To further investigate RPIA-mediated hepatocarcinogenesis, two independent lines of transgenic zebrafish expressing human RPIA …
Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival.
Guo J, Zhang Q, Su Y, Lu X, Wang Y, Yin M, Hu W, Wen W, Lei QY. Guo J, et al. Sci China Life Sci. 2020 Sep;63(9):1394-1405. doi: 10.1007/s11427-019-1562-y. Epub 2020 Mar 6. Sci China Life Sci. 2020. PMID: 32157557
R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with RPIA to induce R42 hypermethylation. ...Importantly, RPIA methylation at R42 significantly potentiates colorectal cancer …
R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with …
Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.
Ciou SC, Chou YT, Liu YL, Nieh YC, Lu JW, Huang SF, Chou YT, Cheng LH, Lo JF, Chen MJ, Yang MC, Yuh CH, Wang HD. Ciou SC, et al. Int J Cancer. 2015 Jul 1;137(1):104-15. doi: 10.1002/ijc.29361. Epub 2014 Dec 12. Int J Cancer. 2015. PMID: 25429733
Here, we report that human ribose-5-phosphate isomerase A (RPIA) plays a role in human hepatocellular carcinoma (HCC). A significant increase in RPIA expression was detected both in tumor biopsies of HCC patients and in a liver cancer tissue array. ...Further …
Here, we report that human ribose-5-phosphate isomerase A (RPIA) plays a role in human hepatocellular carcinoma (HCC). A significant …
WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy.
Hou CY, Ma CY, Lin YJ, Huang CL, Wang HD, Yuh CH. Hou CY, et al. Int J Mol Sci. 2022 Oct 11;23(20):12100. doi: 10.3390/ijms232012100. Int J Mol Sci. 2022. PMID: 36292952 Free PMC article.
In addition, wnk1a and osr1b are upregulated in two liver cancer transgenic fish models: [tert x p53(-/-)] and [HBx,src,p53(-/-),RPIA], while ppp2r1bb is downregulated in [tert x p53(-/-)]. ...Targeting WNK1-OSR1-mediated anti-angiogenesis and anti-cancer act …
In addition, wnk1a and osr1b are upregulated in two liver cancer transgenic fish models: [tert x p53(-/-)] and [HBx,src,p53(-/-),R …
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
Buj R, Chen CW, Dahl ES, Leon KE, Kuskovsky R, Maglakelidze N, Navaratnarajah M, Zhang G, Doan MT, Jiang H, Zaleski M, Kutzler L, Lacko H, Lu Y, Mills GB, Gowda R, Robertson GP, Warrick JI, Herlyn M, Imamura Y, Kimball SR, DeGraff DJ, Snyder NW, Aird KM. Buj R, et al. Cell Rep. 2019 Aug 20;28(8):1971-1980.e8. doi: 10.1016/j.celrep.2019.07.084. Cell Rep. 2019. PMID: 31433975 Free PMC article.
This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomerase A (RPIA), a pentose phosphate pathway enzyme. p16 loss correlates with activation of the mTORC1-RPIA axis in multiple ca …
This occurs by activation of mTORC1 signaling, which directly mediates increased translation of the mRNA encoding ribose-5-phosphate isomera …
30 results