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Progranulin: at the interface of neurodegenerative and metabolic diseases.

Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV Jr. Nguyen AD, et al. Trends Endocrinol Metab. 2013 Dec;24(12):597-606. doi: 10.1016/j.tem.2013.08.003. Epub 2013 Sep 10. Trends Endocrinol Metab. 2013. PMID: 24035620 Free PMC article. Review.

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Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).

Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV Jr. Nguyen AD, et al. J Biol Chem. 2013 Mar 22;288(12):8627-8635. doi: 10.1074/jbc.M112.441949. Epub 2013 Jan 30. J Biol Chem. 2013. PMID: 23364791 Free PMC article.

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Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.

Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV Jr. Martens LH, et al. J Clin Invest. 2012 Nov;122(11):3955-9. doi: 10.1172/JCI63113. Epub 2012 Oct 8. J Clin Invest. 2012. PMID: 23041626 Free PMC article.

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Tau reduction prevents disease in a mouse model of Dravet syndrome.

Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L. Gheyara AL, et al. Ann Neurol. 2014 Sep;76(3):443-56. doi: 10.1002/ana.24230. Epub 2014 Aug 13. Ann Neurol. 2014. PMID: 25042160 Free PMC article.

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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.

Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV Jr, Gitler AD. Armakola M, et al. Nat Genet. 2012 Dec;44(12):1302-9. doi: 10.1038/ng.2434. Epub 2012 Oct 28. Nat Genet. 2012. PMID: 23104007 Free PMC article.

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The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.

King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN. King IN, et al. J Biol Chem. 2014 May 16;289(20):14263-71. doi: 10.1074/jbc.M114.561902. Epub 2014 Apr 9. J Biol Chem. 2014. PMID: 24719334 Free PMC article.

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Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K. Le Moan N, et al. Mol Cell. 2011 Nov 4;44(3):476-90. doi: 10.1016/j.molcel.2011.08.033. Mol Cell. 2011. PMID: 22055192 Free PMC article.

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Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Davalos D, et al. Nat Commun. 2012;3:1227. doi: 10.1038/ncomms2230. Nat Commun. 2012. PMID: 23187627 Free PMC article.

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Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR. Spencer CI, et al. Stem Cell Reports. 2014 Aug 12;3(2):269-81. doi: 10.1016/j.stemcr.2014.06.003. Epub 2014 Jul 4. Stem Cell Reports. 2014. PMID: 25254341 Free PMC article.

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Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.

Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A. Bershteyn M, et al. Nature. 2014 Mar 6;507(7490):99-103. doi: 10.1038/nature12923. Epub 2014 Jan 12. Nature. 2014. PMID: 24413397 Free PMC article.

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