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Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA. Bailis W, et al. Among authors: rabinowitz j. Nature. 2019 Jul;571(7765):403-407. doi: 10.1038/s41586-019-1311-3. Epub 2019 Jun 19. Nature. 2019. PMID: 31217581 Free PMC article.
Branched tricarboxylic acid metabolism in Plasmodium falciparum.
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Olszewski KL, et al. Nature. 2010 Aug 5;466(7307):774-8. doi: 10.1038/nature09301. Nature. 2010. PMID: 20686576 Free PMC article. Retracted.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Commisso C, et al. Among authors: rabinowitz jd. Nature. 2013 May 30;497(7451):633-7. doi: 10.1038/nature12138. Epub 2013 May 12. Nature. 2013. PMID: 23665962 Free PMC article.
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. Jang C, et al. Among authors: rabinowitz jd. Nat Med. 2016 Apr;22(4):421-6. doi: 10.1038/nm.4057. Epub 2016 Mar 7. Nat Med. 2016. PMID: 26950361 Free PMC article.
Glucose feeds the TCA cycle via circulating lactate.
Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD. Hui S, et al. Among authors: rabinowitz jd. Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18. Nature. 2017. PMID: 29045397 Free PMC article.
Mitochondrial translation requires folate-dependent tRNA methylation.
Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Morscher RJ, et al. Among authors: rabinowitz jd. Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24. Nature. 2018. PMID: 29364879 Free PMC article.
1,128 results