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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.
Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Zhang Y, et al. Among authors: rabinowitz jd. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004. Cancer Cell. 2017. PMID: 28898698 Free PMC article.
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Frederick DW, et al. Among authors: rabinowitz jd. Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005. Cell Metab. 2016. PMID: 27508874 Free PMC article.
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. Rebecca VW, et al. Among authors: rabinowitz j. Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12. Cancer Discov. 2017. PMID: 28899863 Free PMC article.
Chemical Basis for Deuterium Labeling of Fat and NADPH.
Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD. Zhang Z, et al. Among authors: rabinowitz jd. J Am Chem Soc. 2017 Oct 18;139(41):14368-14371. doi: 10.1021/jacs.7b08012. Epub 2017 Oct 4. J Am Chem Soc. 2017. PMID: 28911221 Free PMC article.
The Tumor Metabolic Microenvironment: Lessons from Lactate.
García-Cañaveras JC, Chen L, Rabinowitz JD. García-Cañaveras JC, et al. Among authors: rabinowitz jd. Cancer Res. 2019 Jul 1;79(13):3155-3162. doi: 10.1158/0008-5472.CAN-18-3726. Epub 2019 Jun 6. Cancer Res. 2019. PMID: 31171526 Free PMC article. Review.
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC. Ringel AE, et al. Among authors: rabinowitz jd. Cell. 2020 Dec 23;183(7):1848-1866.e26. doi: 10.1016/j.cell.2020.11.009. Epub 2020 Dec 9. Cell. 2020. PMID: 33301708 Free PMC article.
Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.
Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AH. Rowe JH, et al. Among authors: rabinowitz jd. Cancer Discov. 2023 Dec 12;13(12):2566-2583. doi: 10.1158/2159-8290.CD-22-1301. Cancer Discov. 2023. PMID: 37728660
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. Ward PS, et al. Among authors: rabinowitz jd. Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18. Cancer Cell. 2010. PMID: 20171147 Free PMC article.
294 results