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Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.
Ann Intern Med. 2022.
PMID: 35724382
Free PMC article.
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Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.
Dickson AL, Daniel LL, Jackson E, Zanussi J, Yang W, Plummer WD, Dupont WD, Wei WQ, Nepal P, Hung AM, Cox NJ, Van Driest SL, Feng Q, Yang JJ, Stein CM, Mosley JD, Chung CP.
Dickson AL, et al.
Ann Intern Med. 2022 Aug;175(8):1092-1099. doi: 10.7326/M21-4675. Epub 2022 Jun 21.
Ann Intern Med. 2022.
PMID: 35724382
Free PMC article.
DESIGN: Retrospective cohort study. SETTING: Two tertiary care centers. PATIENTS: Thiopurine users with White or Black race. ...LIMITATIONS: Unmeasured confounding; data limited to tertiary centers. CONCLUSION: Patients with the CC genotype had higher …
DESIGN: Retrospective cohort study. SETTING: Two tertiary care centers. PATIENTS: Thiopurine users with White or Black race …
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TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results.
Dickson AL, Daniel LL, Zanussi J, Dale Plummer W, Wei WQ, Liu G, Reese T, Anandi P, Birdwell KA, Kawai V, Cox NJ, Dupont WD, Hung AM, Feng Q, Stein CM, Chung CP.
Dickson AL, et al.
Clin Pharmacol Ther. 2022 Jan;111(1):263-271. doi: 10.1002/cpt.2428. Epub 2021 Oct 12.
Clin Pharmacol Ther. 2022.
PMID: 34582038
Free PMC article.
We hypothesized that in patients with inflammatory diseases, TPMT and NUDT15 genotype data predict the risk of discontinuing azathioprine due to myelotoxicity. This was a retrospective cohort study in 1,403 new adult azathioprine users fo …
We hypothesized that in patients with inflammatory diseases, TPMT and NUDT15 genotype data predict the risk of discontinuing …
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