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The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. Evans CM, et al. Among authors: raclawska ds. Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281. Nat Commun. 2015. PMID: 25687754 Free PMC article.
Disulfide disruption reverses mucus dysfunction in allergic airway disease.
Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Morgan LE, et al. Nat Commun. 2021 Jan 11;12(1):249. doi: 10.1038/s41467-020-20499-0. Nat Commun. 2021. PMID: 33431872 Free PMC article.