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LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Ferreirós N, Labocha S, Schröder M, Radeke HH, Geisslinger G. Ferreirós N, et al. Among authors: radeke hh. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:122-7. doi: 10.1016/j.jchromb.2012.01.023. Epub 2012 Jan 30. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22341683
Interference with MCP-1 gene expression by vector generated triple helix-forming RNA oligonucleotides.
Kautz K, Schwarz M, Radeke HH. Kautz K, et al. Among authors: radeke hh. Cell Mol Life Sci. 2005 Feb;62(3):362-76. doi: 10.1007/s00018-004-4443-y. Cell Mol Life Sci. 2005. PMID: 15723171
Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.
Radeke HH, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B. Radeke HH, et al. J Immunol. 2005 Mar 1;174(5):2778-86. doi: 10.4049/jimmunol.174.5.2778. J Immunol. 2005. PMID: 15728487
Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.
Keller CD, Rivera Gil P, Tölle M, van der Giet M, Chun J, Radeke HH, Schäfer-Korting M, Kleuser B. Keller CD, et al. Among authors: radeke hh. Am J Pathol. 2007 Jan;170(1):281-92. doi: 10.2353/ajpath.2007.060485. Am J Pathol. 2007. PMID: 17200201 Free PMC article.
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Daniel C, Sartory N, Zahn N, Geisslinger G, Radeke HH, Stein JM. Daniel C, et al. Among authors: radeke hh. J Immunol. 2007 Feb 15;178(4):2458-68. doi: 10.4049/jimmunol.178.4.2458. J Immunol. 2007. PMID: 17277153
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, Stein JM. Daniel C, et al. Among authors: radeke hh. Mol Immunol. 2007 Jul;44(13):3305-16. doi: 10.1016/j.molimm.2007.02.026. Epub 2007 May 1. Mol Immunol. 2007. PMID: 17475330
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH. Schröder M, et al. Among authors: radeke hh. Mol Immunol. 2011 May;48(9-10):1139-48. doi: 10.1016/j.molimm.2011.02.007. Epub 2011 Mar 23. Mol Immunol. 2011. PMID: 21435724
Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo.
Arlt O, Schwiebs A, Japtok L, Rüger K, Katzy E, Kleuser B, Radeke HH. Arlt O, et al. Among authors: radeke hh. Cell Physiol Biochem. 2014;34(1):27-44. doi: 10.1159/000362982. Epub 2014 Jun 16. Cell Physiol Biochem. 2014. PMID: 24977479 Review.
Modulation of IL-33/ST2-TIR and TLR signalling pathway by fingolimod and analogues in immune cells.
Rüger K, Ottenlinger F, Schröder M, Zivković A, Stark H, Pfeilschifter JM, Radeke HH. Rüger K, et al. Among authors: radeke hh. Scand J Immunol. 2014 Dec;80(6):398-407. doi: 10.1111/sji.12238. Scand J Immunol. 2014. PMID: 25207757
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application.
Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, Radeke HH. Schröder M, et al. Among authors: radeke hh. Biol Chem. 2015 Jun;396(6-7):795-802. doi: 10.1515/hsz-2014-0287. Biol Chem. 2015. PMID: 25720062
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