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Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways.
Vanamala J, Reddivari L, Radhakrishnan S, Tarver C. Vanamala J, et al. Among authors: radhakrishnan s. BMC Cancer. 2010 May 26;10:238. doi: 10.1186/1471-2407-10-238. BMC Cancer. 2010. PMID: 20504360 Free PMC article.
RESULTS: Resveratrol (100-150 microM) exhibited anti-proliferative properties in HT-29 cells even after IGF-1 exposure by arresting G0/G1-S phase cell cycle progression through p27 stimulation and cyclin D1 suppression. ...
RESULTS: Resveratrol (100-150 microM) exhibited anti-proliferative properties in HT-29 cells even after IGF-1 exposure by arresting G0/G1- …
Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.
Charepalli V, Reddivari L, Radhakrishnan S, Vadde R, Agarwal R, Vanamala JK. Charepalli V, et al. Among authors: radhakrishnan s. J Nutr Biochem. 2015 Dec;26(12):1641-9. doi: 10.1016/j.jnutbio.2015.08.005. Epub 2015 Aug 14. J Nutr Biochem. 2015. PMID: 26383537
Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio.
Vadde R, Radhakrishnan S, Reddivari L, Vanamala JK. Vadde R, et al. Among authors: radhakrishnan s. Biomed Res Int. 2015;2015:649263. doi: 10.1155/2015/649263. Epub 2015 Jun 17. Biomed Res Int. 2015. PMID: 26167492 Free PMC article.
Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds.
Kasdagly M, Radhakrishnan S, Reddivari L, Veeramachaneni DN, Vanamala J. Kasdagly M, et al. Among authors: radhakrishnan s. Nutrition. 2014 Nov-Dec;30(11-12):1242-56. doi: 10.1016/j.nut.2014.02.016. Epub 2014 Mar 12. Nutrition. 2014. PMID: 25280404 Review.
Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach.
Vanamala J, Radhakrishnan S, Reddivari L, Bhat VB, Ptitsyn A. Vanamala J, et al. Among authors: radhakrishnan s. Proteome Sci. 2011 Aug 17;9(1):49. doi: 10.1186/1477-5956-9-49. Proteome Sci. 2011. PMID: 21849056 Free PMC article.
Particularly, little information is available on RSV's effects on metabolic pathways and the cell-extra cellular matrix (ECM) communication that are critical for cancer cell growth. ...
Particularly, little information is available on RSV's effects on metabolic pathways and the cell-extra cellular matrix (ECM) communi …
Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis.
Radhakrishnan S, Reddivari L, Sclafani R, Das UN, Vanamala J. Radhakrishnan S, et al. Front Biosci (Elite Ed). 2011 Jun 1;3:1509-23. doi: 10.2741/e352. Front Biosci (Elite Ed). 2011. PMID: 21622155
A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis.
Sido A, Radhakrishnan S, Kim SW, Eriksson E, Shen F, Li Q, Bhat V, Reddivari L, Vanamala JKP. Sido A, et al. Among authors: radhakrishnan s. J Nutr Biochem. 2017 May;43:11-17. doi: 10.1016/j.jnutbio.2017.01.012. Epub 2017 Jan 28. J Nutr Biochem. 2017. PMID: 28193578
Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis.
Reddivari L, Charepalli V, Radhakrishnan S, Vadde R, Elias RJ, Lambert JD, Vanamala JK. Reddivari L, et al. Among authors: radhakrishnan s. BMC Complement Altern Med. 2016 Aug 9;16:278. doi: 10.1186/s12906-016-1254-2. BMC Complement Altern Med. 2016. PMID: 27506388 Free PMC article.
Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance.
Charepalli V, Reddivari L, Radhakrishnan S, Eriksson E, Xiao X, Kim SW, Shen F, Vijay-Kumar M, Li Q, Bhat VB, Knight R, Vanamala JKP. Charepalli V, et al. Among authors: radhakrishnan s. Cancer Prev Res (Phila). 2017 Aug;10(8):442-450. doi: 10.1158/1940-6207.CAPR-17-0010. Epub 2017 Jun 2. Cancer Prev Res (Phila). 2017. PMID: 28576788 Free PMC article.
Eugenia jambolana (Java Plum) Fruit Extract Exhibits Anti-Cancer Activity against Early Stage Human HCT-116 Colon Cancer Cells and Colon Cancer Stem Cells.
Charepalli V, Reddivari L, Vadde R, Walia S, Radhakrishnan S, Vanamala JK. Charepalli V, et al. Among authors: radhakrishnan s. Cancers (Basel). 2016 Feb 26;8(3):29. doi: 10.3390/cancers8030029. Cancers (Basel). 2016. PMID: 26927179 Free PMC article.
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