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Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease.
Schreiber S, Heinig T, Thiele HG, Raedler A. Schreiber S, et al. Among authors: raedler a. Gastroenterology. 1995 May;108(5):1434-44. doi: 10.1016/0016-5085(95)90692-4. Gastroenterology. 1995. PMID: 7729636
Deficiency of interleukin (IL) 10, a contrainflammatory cytokine, leads to the development of colitis in IL-10 knockout mice. ...RESULTS: IL-10 down-regulates IL-1 beta and TNF-alpha secretion as well as messenger RNA levels in IBD peripheral monocytes and LPMNC in a
Deficiency of interleukin (IL) 10, a contrainflammatory cytokine, leads to the development of colitis in IL-10 knockout mice. ...RESU …
Mechanisms in failure of infliximab for Crohn's disease.
Nikolaus S, Raedler A, Kühbacker T, Sfikas N, Fölsch UR, Schreiber S. Nikolaus S, et al. Among authors: raedler a. Lancet. 2000 Oct 28;356(9240):1475-9. doi: 10.1016/s0140-6736(00)02871-3. Lancet. 2000. PMID: 11081530 Clinical Trial.
Treatment with monoclonal antibodies to TNF (infliximab) in refractory Crohn's disease results in a remission rate of 30-50% after 4 weeks. ...Relapsers were characterised by a rise in TNF-alpha secretion capacity and by increase of mucosal nuclear NFkappaB p65 befo …
Treatment with monoclonal antibodies to TNF (infliximab) in refractory Crohn's disease results in a remission rate of 30-50% after 4 …
Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease.
Schreiber S, Nikolaus S, Hampe J, Hämling J, Koop I, Groessner B, Lochs H, Raedler A. Schreiber S, et al. Among authors: raedler a. Lancet. 1999 Feb 6;353(9151):459-61. doi: 10.1016/S0140-6736(98)03339-X. Lancet. 1999. PMID: 9989717
INTERPRETATION: TNF alpha is important as a target molecule for immune interventions in Crohn's disease. The capacity to produce TNF alpha or interleukin 1beta may identify patients who would benefit from anti-inflammatory remission maintenance....
INTERPRETATION: TNF alpha is important as a target molecule for immune interventions in Crohn's disease. The capacity to produce TNF …
Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease.
Bauditz J, Haemling J, Ortner M, Lochs H, Raedler A, Schreiber S. Bauditz J, et al. Among authors: raedler a. Gut. 1997 Apr;40(4):470-4. doi: 10.1136/gut.40.4.470. Gut. 1997. PMID: 9176073 Free PMC article. Clinical Trial.
TNF alpha can induce a host of cellular effector events resulting in perpetuation of the inflammatory process. In vivo studies with anti-TNF alpha antibody treatment have led to impressive clinical results. ...METHODS: Sixteen Crohn's disease patients received oxpentifylli …
TNF alpha can induce a host of cellular effector events resulting in perpetuation of the inflammatory process. In vivo studies with a …
Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.
Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A. Reinecker HC, et al. Among authors: raedler a. Clin Exp Immunol. 1993 Oct;94(1):174-81. doi: 10.1111/j.1365-2249.1993.tb05997.x. Clin Exp Immunol. 1993. PMID: 8403503 Free PMC article.
The secretion patterns of TNF-alpha and IL-1 beta by LPMNC from patients with either ulcerative colitis or Crohn's disease demonstrated a close correlation with the degree of tissue involvement and mucosal inflammation. ...The determination of proinflammatory cytokine secr …
The secretion patterns of TNF-alpha and IL-1 beta by LPMNC from patients with either ulcerative colitis or Crohn's disease demonstrated a
Combined alpha-methylacyl coenzyme A racemase/p53 analysis to identify dysplasia in inflammatory bowel disease.
Marx A, Wandrey T, Simon P, Wewer A, Grob T, Reichelt U, Minner S, Simon R, Spehlmann M, Tigges W, Soehendra N, Seitz U, Seewald S, Izbicki JR, Yekebas E, Kaifi JT, Mirlacher M, Terracciano L, Fleischmann A, Raedler A, Sauter G. Marx A, et al. Among authors: raedler a. Hum Pathol. 2009 Feb;40(2):166-73. doi: 10.1016/j.humpath.2008.06.027. Epub 2008 Oct 5. Hum Pathol. 2009. PMID: 18835622
[The mucosa-associated immune system--immune defense in the gastrointestinal tract].
Schreiber S, Raedler A. Schreiber S, et al. Among authors: raedler a. Immun Infekt. 1993 Apr;21 Suppl 1:31-3. Immun Infekt. 1993. PMID: 8344684 Review. German.
The composition of mononuclear cells in the lamina propria exhibits the preference of a memory T cell type that is able to provide help for B cells. ...
The composition of mononuclear cells in the lamina propria exhibits the preference of a memory T cell type that is able to provide he …
Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat.
Lenz HJ, Burlage M, Raedler A, Greten H. Lenz HJ, et al. Among authors: raedler a. Gastroenterology. 1988 Mar;94(3):598-602. doi: 10.1016/0016-5085(88)90229-6. Gastroenterology. 1988. PMID: 3257450
Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bowel transit, but most markedly increased large bowel transit in a dose-related fashion in freely moving rats. ...It is concluded that …
Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bow …
Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor.
Lenz HJ, Raedler A, Greten H, Vale WW, Rivier JE. Lenz HJ, et al. Among authors: raedler a. Gastroenterology. 1988 Dec;95(6):1510-7. doi: 10.1016/s0016-5085(88)80070-2. Gastroenterology. 1988. PMID: 2846402
Cerebroventricular administration of a specific CRF receptor antagonist, alpha-helical CRF-(9-41), but not of the CRF fragment CRF-(1-20), prevented the gastrointestinal secretory and motor responses elicited either by partial body restraint or by exogenous administration …
Cerebroventricular administration of a specific CRF receptor antagonist, alpha-helical CRF-(9-41), but not of the CRF fragment CRF-(1 …
Rotavirus antigen detection in patients with HIV infection and diarrhea.
Albrecht H, Stellbrink HJ, Fenske S, Ermer M, Raedler A, Greten H. Albrecht H, et al. Among authors: raedler a. Scand J Gastroenterol. 1993 Apr;28(4):307-10. doi: 10.3109/00365529309090246. Scand J Gastroenterol. 1993. PMID: 8387694
A wide variety of bacterial, viral, and parasitic pathogens can cause severe diarrhea in patients with advanced human immunodeficiency virus (HIV) infection. ...A seasonal variation, typical of infantile rotavirus infection, was not observed in this setting. While r
A wide variety of bacterial, viral, and parasitic pathogens can cause severe diarrhea in patients with advanced human immunodeficienc
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