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Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice.
Bachmann S, Mutig K, Bates J, Welker P, Geist B, Gross V, Luft FC, Alenina N, Bader M, Thiele BJ, Prasadan K, Raffi HS, Kumar S. Bachmann S, et al. Among authors: raffi hs. Am J Physiol Renal Physiol. 2005 Mar;288(3):F559-67. doi: 10.1152/ajprenal.00143.2004. Epub 2004 Nov 2. Am J Physiol Renal Physiol. 2005. PMID: 15522986 Free article.
Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner.
Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Raffi H, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castañeda-Bueno M, Gamba G, Bachmann S. Mutig K, et al. J Biol Chem. 2011 Aug 26;286(34):30200-10. doi: 10.1074/jbc.M111.222968. Epub 2011 Jul 7. J Biol Chem. 2011. PMID: 21737451 Free PMC article.
Validation of uromodulin as a candidate gene for human essential hypertension.
Graham LA, Padmanabhan S, Fraser NJ, Kumar S, Bates JM, Raffi HS, Welsh P, Beattie W, Hao S, Leh S, Hultstrom M, Ferreri NR, Dominiczak AF, Graham D, McBride MW. Graham LA, et al. Among authors: raffi hs. Hypertension. 2014 Mar;63(3):551-8. doi: 10.1161/HYPERTENSIONAHA.113.01423. Epub 2013 Dec 9. Hypertension. 2014. PMID: 24324041