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Page 1
Did you mean irafoxanide (1 results)?
Rafoxanide negatively modulates STAT3 and NF-kappaB activity and inflammation-associated colon tumorigenesis.
Pacifico T, Stolfi C, Tomassini L, Luiz-Ferreira A, Franzè E, Ortenzi A, Colantoni A, Sica GS, Sambucci M, Monteleone I, Monteleone G, Laudisi F. Pacifico T, et al. Cancer Sci. 2024 Nov;115(11):3596-3611. doi: 10.1111/cas.16317. Epub 2024 Sep 6. Cancer Sci. 2024. PMID: 39239848 Free PMC article.
Here, we investigate whether rafoxanide could negatively modulate STAT3/NF-kappaB and inflammation-associated CRC. The antineoplastic effect of rafoxanide was explored in a murine model of CRC resembling colitis-associated disease. ...Our data suggest that rafoxa …
Here, we investigate whether rafoxanide could negatively modulate STAT3/NF-kappaB and inflammation-associated CRC. The antineoplastic …
Repurposing Rafoxanide: From Parasite Killer to Cancer Fighter.
Pacifico T, Tomassini L, Biancone L, Monteleone G, Stolfi C, Laudisi F. Pacifico T, et al. Biomedicines. 2025 Jul 9;13(7):1686. doi: 10.3390/biomedicines13071686. Biomedicines. 2025. PMID: 40722758 Free PMC article. Review.
Rafoxanide, originally developed as a veterinary anthelmintic for the treatment of parasitic infections in livestock, has recently emerged as a promising therapeutic prospect in oncology. ...This multitargeted mode of action distinguishes rafoxanide from conventiona …
Rafoxanide, originally developed as a veterinary anthelmintic for the treatment of parasitic infections in livestock, has recently em …
Repositioning rafoxanide to treat Gram-negative bacilli infections.
Miró-Canturri A, Ayerbe-Algaba R, Villodres ÁR, Pachón J, Smani Y. Miró-Canturri A, et al. J Antimicrob Chemother. 2020 Jul 1;75(7):1895-1905. doi: 10.1093/jac/dkaa103. J Antimicrob Chemother. 2020. PMID: 32240294 Free article.
A murine peritoneal sepsis model using Col-R strains of these pathogens was performed to study the efficacy of rafoxanide (10 mg/kg/24 h, IV), colistimethate sodium (CMS) (20 mg/kg/8 h, intraperitoneally) and rafoxanide (10 mg/kg/24 h, IV) plus CMS (20 mg/kg/8 h, in …
A murine peritoneal sepsis model using Col-R strains of these pathogens was performed to study the efficacy of rafoxanide (10 mg/kg/2 …
Rafoxanide Induces Immunogenic Death of Colorectal Cancer Cells.
Di Grazia A, Laudisi F, Di Fusco D, Franzè E, Ortenzi A, Monteleone I, Monteleone G, Stolfi C. Di Grazia A, et al. Cancers (Basel). 2020 May 21;12(5):1314. doi: 10.3390/cancers12051314. Cancers (Basel). 2020. PMID: 32455811 Free PMC article.
In addition, the immunogenic potential of rafoxanide was assessed in vivo using a vaccination assay. Rafoxanide induced all the main DAMPs (ecto-calreticulin exposure, adenosine triphosphate (ATP)/high mobility group box 1 (HMGB1) release) required for ICD. We obser …
In addition, the immunogenic potential of rafoxanide was assessed in vivo using a vaccination assay. Rafoxanide induced all th …
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin.
Yokoyama T, Mizuguchi M, Nabeshima Y, Nakagawa Y, Okada T, Toyooka N, Kusaka K. Yokoyama T, et al. FEBS J. 2023 Nov;290(21):5158-5170. doi: 10.1111/febs.16915. Epub 2023 Aug 7. FEBS J. 2023. PMID: 37522420 Free article.
An intrinsic fluorescence quenching assay showed that rafoxanide also binds to the thyroid hormone-related proteins, including serum albumin and thyroid hormone receptor beta. Rafoxanide strongly inhibited TTR amyloidogenesis in fibrillization assay, but the binding …
An intrinsic fluorescence quenching assay showed that rafoxanide also binds to the thyroid hormone-related proteins, including serum …
The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in Klebsiella pneumoniae.
Han R, Xing J, Sun H, Guo Z, Yi K, Hu G, Zhai Y, Velkov T, Wu H. Han R, et al. mSphere. 2023 Oct 24;8(5):e0023423. doi: 10.1128/msphere.00234-23. Epub 2023 Sep 25. mSphere. 2023. PMID: 37747188 Free PMC article.
Treatment with 1 mg/L rafoxanide overtly reversed the MIC max to 512-fold. Time-kill assays indicated that rafoxanide acted synergistically with colistin against the growth of KP-1 and KP-9. ...These novel findings highlight the synergistic mechanism of rafoxanid …
Treatment with 1 mg/L rafoxanide overtly reversed the MIC max to 512-fold. Time-kill assays indicated that rafoxanide acted sy …
Rafoxanide sensitizes colorectal cancer cells to TRAIL-mediated apoptosis.
Laudisi F, Pacifico T, Maresca C, Luiz-Ferreira A, Antonelli S, Ortenzi A, Colantoni A, Di Grazia A, Franzè E, Colella M, Di Fusco D, Sica GS, Monteleone I, Monteleone G, Stolfi C. Laudisi F, et al. Biomed Pharmacother. 2022 Nov;155:113794. doi: 10.1016/j.biopha.2022.113794. Epub 2022 Oct 4. Biomed Pharmacother. 2022. PMID: 36271571 Free article.
Agents able to overcome CRC cell resistance to TRAIL have thus great therapeutic potential and many researchers are making efforts to identify TRAIL sensitizers. The anthelmintic drug rafoxanide has recently emerged as a potent anti-tumor molecule for different cancer type …
Agents able to overcome CRC cell resistance to TRAIL have thus great therapeutic potential and many researchers are making efforts to identi …
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
Hu A, Liu J, Wang Y, Zhang M, Guo Y, Qin Y, Liu T, Men Y, Chen Q, Liu T. Hu A, et al. Sci Rep. 2023 Jan 13;13(1):693. doi: 10.1038/s41598-023-27403-y. Sci Rep. 2023. PMID: 36639421 Free PMC article.
In this study, we examined the effect of rafoxanide on NSCLC and dissected the underlying mechanism. The results showed that rafoxanide significantly inhibited the growth, invasion, and migration of NSCLC cells. Besides, rafoxanide can induce NSCLC cell apopt …
In this study, we examined the effect of rafoxanide on NSCLC and dissected the underlying mechanism. The results showed that rafox …
Therapeutic Switching of Rafoxanide: a New Approach To Fighting Drug-Resistant Bacteria and Fungi.
Bendary MM, Abd El-Hamid MI, Abousaty AI, Elmanakhly AR, Alshareef WA, Mosbah RA, Alhomrani M, Ghoneim MM, Elkelish A, Hashim N, Alamri AS, Al-Harthi HF, Safwat NA. Bendary MM, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0267922. doi: 10.1128/spectrum.02679-22. Epub 2023 Jul 17. Microbiol Spectr. 2023. PMID: 37458598 Free PMC article.
In short, rafoxanide exhibited promising results in overcoming bacterial and fungal drug resistance. ...The coadministration of antibiotics with rafoxanide can prevent the failure of treatment of both resistant bacteria and fungi, as the resistant pathogens could be …
In short, rafoxanide exhibited promising results in overcoming bacterial and fungal drug resistance. ...The coadministration of antib …
192 results