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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 3
1984 3
1985 2
1987 2
1988 2
1989 1
1995 1
1996 1
1997 2
1998 2
1999 1
2000 2
2001 2
2002 2
2003 2
2004 3
2005 2
2006 2
2007 1
2008 2
2009 4
2010 4
2011 6
2012 11
2013 6
2014 3
2015 9
2016 7
2017 2
2018 7
2019 8
2020 2
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100 results
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Page 1
Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors
Balakrishnan SS, et al. J Cell Sci 2018. Among authors: Raghu P. PMID 29980590 Free PMC article.
PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)], and continued signaling requires the resynthesis and availability of PI(4,5)P(2) at the plasma membrane. ...Thus, PI4KIIIα activity at the plasma membrane generates PI4P and supports PI(4,5)P(2) levels during receptor activated PLC signaling....
PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)], and continued signaling requires the res …
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
Sharma S, et al. Cell Rep 2019. Among authors: Raghu P. PMID 31091438 Free PMC article.
We find that PIP4K function at the plasma membrane enhances class I phosphoinositide 3-kinase (PI3K) activity, although the catalytic ability of PIP4K to produce phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] at the plasma membrane is dispensable for this regulation. ...
We find that PIP4K function at the plasma membrane enhances class I phosphoinositide 3-kinase (PI3K) activity, although the catalytic abilit …
Phosphoinositide signalling in Drosophila
Balakrishnan SS, et al. Biochim Biophys Acta 2015 - Review. Among authors: Raghu P. PMID 25449646
Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap
Cockcroft S and Raghu P. Biochem J 2016 - Review. PMID 27888240
Conversely, PI from the ER needs to be rapidly transferred to the PM where it can be phosphorylated by lipid kinases to regenerate PI(4,5)P(2) Thus, two lipid transport steps between membrane compartments through the cytosol are required for the replenishment of PI(4,5)P(2) at the PM. Here, we review the topological constraints in the PI(4,5)P(2) cycle and current understanding how these constraints are overcome during PLC signalling. ...
Conversely, PI from the ER needs to be rapidly transferred to the PM where it can be phosphorylated by lipid kinases to regenerate PI(4,5) …
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