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Multiple activities of a multifaceted receptor: roles of cleaved and soluble uPAR.
Montuori N, Ragno P. Montuori N, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:2494-503. doi: 10.2741/3392. Front Biosci (Landmark Ed). 2009. PMID: 19273214 Review.
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion.
Pesapane A, Di Giovanni C, Rossi FW, Alfano D, Formisano L, Ragno P, Selleri C, Montuori N, Lavecchia A. Pesapane A, et al. Among authors: ragno p. Oncotarget. 2015 Jul 20;6(20):18116-33. doi: 10.18632/oncotarget.4016. Oncotarget. 2015. PMID: 26062445 Free PMC article.
Discovery of new small molecules targeting the vitronectin-binding site of the urokinase receptor that block cancer cell invasion.
Rea VE, Lavecchia A, Di Giovanni C, Rossi FW, Gorrasi A, Pesapane A, de Paulis A, Ragno P, Montuori N. Rea VE, et al. Mol Cancer Ther. 2013 Aug;12(8):1402-16. doi: 10.1158/1535-7163.MCT-12-1249. Epub 2013 May 22. Mol Cancer Ther. 2013. PMID: 23699658
RhoB regulates uPAR signalling.
Alfano D, Ragno P, Stoppelli MP, Ridley AJ. Alfano D, et al. J Cell Sci. 2012 May 15;125(Pt 10):2369-80. doi: 10.1242/jcs.091579. Epub 2012 Feb 24. J Cell Sci. 2012. PMID: 22366462
uPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLF-receptors.
Montuori N, Cosimato V, Rinaldi L, Rea VE, Alfano D, Ragno P. Montuori N, et al. Thromb Haemost. 2013 Feb;109(2):309-18. doi: 10.1160/TH12-08-0546. Epub 2012 Dec 13. Thromb Haemost. 2013. PMID: 23238745
Accordingly, uPAR depletion impairs uPA expression in cells which constitutively express both uPA and its receptor. uPAR exerts its regulatory effect through the activation of the ERK mitogen-activated protein kinases (MAPKs), whereas the p-38 MAPK is not involved. ...Inhi …
Accordingly, uPAR depletion impairs uPA expression in cells which constitutively express both uPA and its receptor. uPAR exerts its regulato …
In vivo activity of the cleaved form of soluble urokinase receptor: a new hematopoietic stem/progenitor cell mobilizer.
Selleri C, Montuori N, Ricci P, Visconte V, Baiano A, Carriero MV, Rotoli B, Rossi G, Ragno P. Selleri C, et al. Cancer Res. 2006 Nov 15;66(22):10885-90. doi: 10.1158/0008-5472.CAN-06-1311. Cancer Res. 2006. PMID: 17108125
We first showed that uPAR(84-95) stimulated in vitro dose-dependent migration of mouse CD34(+) M1 leukemia cells and inactivated murine CXCR4. uPAR(84-95) capability to induce mouse HSC/HPC release from bone marrow and migration into the circulation was then investigated in vivo. …
We first showed that uPAR(84-95) stimulated in vitro dose-dependent migration of mouse CD34(+) M1 leukemia cells and inactivated murine CXCR …
N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor.
Napolitano F, Rossi FW, Pesapane A, Varricchio S, Ilardi G, Mascolo M, Staibano S, Lavecchia A, Ragno P, Selleri C, Marone G, Matucci-Cerinic M, de Paulis A, Montuori N. Napolitano F, et al. Among authors: ragno p. Front Immunol. 2018 Apr 4;9:574. doi: 10.3389/fimmu.2018.00574. eCollection 2018. Front Immunol. 2018. PMID: 29670612 Free PMC article.
Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer.
Montuori N, Pesapane A, Rossi FW, Giudice V, De Paulis A, Selleri C, Ragno P. Montuori N, et al. Among authors: ragno p. Transl Med UniSa. 2016 Nov 1;15:15-21. eCollection 2016 Nov. Transl Med UniSa. 2016. PMID: 27896223 Free PMC article.
Involvement of urokinase receptor in the cross-talk between human hematopoietic stem cells and bone marrow microenvironment.
Selleri C, Montuori N, Salvati A, Serio B, Pesapane A, Ricci P, Gorrasi A, Li Santi A, Hoyer-Hansen G, Ragno P. Selleri C, et al. Among authors: ragno p. Oncotarget. 2016 Sep 13;7(37):60206-60217. doi: 10.18632/oncotarget.11115. Oncotarget. 2016. PMID: 27517491 Free PMC article.
Urokinase receptor and CXCR4 are regulated by common microRNAs in leukaemia cells.
Alfano D, Gorrasi A, Li Santi A, Ricci P, Montuori N, Selleri C, Ragno P. Alfano D, et al. Among authors: ragno p. J Cell Mol Med. 2015 Sep;19(9):2262-72. doi: 10.1111/jcmm.12617. Epub 2015 Jun 16. J Cell Mol Med. 2015. PMID: 26082201 Free PMC article.
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