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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.
Thérien M, Skorey K, Zamboni R, Li CS, Lau CK, LeRiche T, Linh Truong V, Waddleton D, Ramachandran C. Thérien M, et al. Among authors: ramachandran c. Bioorg Med Chem Lett. 2004 May 3;14(9):2319-22. doi: 10.1016/j.bmcl.2004.01.101. Bioorg Med Chem Lett. 2004. PMID: 15081032
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Lau CK, Bayly CI, Gauthier JY, Li CS, Therien M, Asante-Appiah E, Cromlish W, Boie Y, Forghani F, Desmarais S, Wang Q, Skorey K, Waddleton D, Payette P, Ramachandran C, Kennedy BP, Scapin G. Lau CK, et al. Among authors: ramachandran c. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1043-8. doi: 10.1016/j.bmcl.2003.11.076. Bioorg Med Chem Lett. 2004. PMID: 15013020
The development of potent non-peptidic PTP-1B inhibitors.
Dufresne C, Roy P, Wang Z, Asante-Appiah E, Cromlish W, Boie Y, Forghani F, Desmarais S, Wang Q, Skorey K, Waddleton D, Ramachandran C, Kennedy BP, Xu L, Gordon R, Chan CC, Leblanc Y. Dufresne C, et al. Among authors: ramachandran c. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1039-42. doi: 10.1016/j.bmcl.2003.11.048. Bioorg Med Chem Lett. 2004. PMID: 15013019
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Scapin G, Patel SB, Becker JW, Wang Q, Desponts C, Waddleton D, Skorey K, Cromlish W, Bayly C, Therien M, Gauthier JY, Li CS, Lau CK, Ramachandran C, Kennedy BP, Asante-Appiah E. Scapin G, et al. Among authors: ramachandran c. Biochemistry. 2003 Oct 7;42(39):11451-9. doi: 10.1021/bi035098j. Biochemistry. 2003. PMID: 14516196
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