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The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.
Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. Ramanathan A, et al. Nucleic Acids Res. 2016 Jan 29;44(2):896-909. doi: 10.1093/nar/gkv1299. Epub 2015 Nov 26. Nucleic Acids Res. 2016. PMID: 26612866 Free PMC article.
These features found in many pathogenic RNAs are absent in cellular RNAs due to post-transcriptional modifications of RNA ends. Although RIG-I is structurally well characterized, the mechanistic basis for RIG-I's remarkable ability to discriminate betw …
These features found in many pathogenic RNAs are absent in cellular RNAs due to post-transcriptional modifications of RNA ends. Although …
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J. Jiang F, et al. Among authors: ramanathan a. Nature. 2011 Sep 25;479(7373):423-7. doi: 10.1038/nature10537. Nature. 2011. PMID: 21947008 Free PMC article.
Here, to understand the synergy between the helicase and the RD for RNA binding, and the contribution of ATP hydrolysis to RIG-I activation, we determined the structure of human RIG-I helicase-RD in complex with dsRNA and an ATP analogue. ...The RIG
Here, to understand the synergy between the helicase and the RD for RNA binding, and the contribution of ATP hydrolysis to RIG-I
Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J. Devarkar SC, et al. Among authors: ramanathan a. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):596-601. doi: 10.1073/pnas.1515152113. Epub 2016 Jan 5. Proc Natl Acad Sci U S A. 2016. PMID: 26733676 Free PMC article.
Here we provide structural and mechanistic basis for exact roles of capping and 2'-O-methylation in evading RIG-I recognition. Surprisingly, Cap-0 and 5'ppp double-stranded (ds) RNAs bind to RIG-I with nearly identical Kd values and activate RIG
Here we provide structural and mechanistic basis for exact roles of capping and 2'-O-methylation in evading RIG-I recognition. …