Ramsden DA - Search Results

Year	Number of Results
1976	2
1977	1
1989	1
1990	1
1991	1
1992	1
1994	3
1995	5
1996	3
1997	2
1998	1
1999	1
2000	1
2002	4
2003	3
2004	4
2005	1
2006	2
2007	4
2008	3
2009	3
2010	4
2011	1
2012	4
2013	1
2014	5
2015	3
2016	3
2017	6
2018	2
2019	2
2020	6
2021	5
2022	3
2023	3
2024	4
2025	6
2026	0

1

Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break.

Luthman AJ, Chiruvella KK, Kaminski AM, Kunkel TA, Pedersen LC, Ramsden DA. Luthman AJ, et al. Among authors: ramsden da. Nat Commun. 2025 Nov 24;16(1):11599. doi: 10.1038/s41467-025-66528-8. Nat Commun. 2025. PMID: 41285786 Free PMC article.

2

Polymerase θ-what does it see, and why does it matter for cancer therapy?

Ramsden DA, Gupta GP. Ramsden DA, et al. NAR Cancer. 2025 Nov 6;7(4):zcaf042. doi: 10.1093/narcan/zcaf042. eCollection 2025 Dec. NAR Cancer. 2025. PMID: 41216604 Free PMC article. Review.

3

Distinctive molecular features of radiation-induced thyroid cancers.

Karyadi DM, Bogdanova TI, Milder CM, Hartley SW, Lee OW, Dean M, Drozdovitch V, Cahoon EK, Masiuk S, Chepurny M, Zurnadzhy LY, Vij V, Kitahara CM, Thomas GA, Woloschak GE, Ramsden DA, Tronko MD, Chanock SJ, Morton LM. Karyadi DM, et al. Among authors: ramsden da. Sci Adv. 2025 Aug 22;11(34):eadw7680. doi: 10.1126/sciadv.adw7680. Epub 2025 Aug 22. Sci Adv. 2025. PMID: 40845117 Free PMC article.

4

Monkey business: Primate Ku moonlights for the innate immune response.

Ramsden DA, Luthman AJ. Ramsden DA, et al. Mol Cell. 2025 Jul 17;85(14):2633-2635. doi: 10.1016/j.molcel.2025.06.022. Mol Cell. 2025. PMID: 40680720

5

Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse.

Smith CM, Simpson DA, Guerra P, Feng W, Ellington SW, Lu D, Fijen C, Boylston NM, Chiruvella KK, El-Shiekh I, Lee R, Wozny AS, Pregnall AM, Eckenroth BE, El-Sagheer AH, Brown T, Doublié S, Ramsden DA, Rothenberg E, Nik-Zainal S, Gupta GP. Smith CM, et al. Among authors: ramsden da. bioRxiv [Preprint]. 2025 Jul 3:2025.07.02.662846. doi: 10.1101/2025.07.02.662846. bioRxiv. 2025. PMID: 40631081 Free PMC article. Preprint.

6

BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance.

Chung OW, Yao S, Yang F, Wang L, Cerda-Smith C, Hutchinson HM, Wood KC, Su W, Khasraw M, Zou L, Ramsden DA, Zhang ZZ. Chung OW, et al. Among authors: ramsden da. bioRxiv [Preprint]. 2025 Feb 23:2025.02.18.638901. doi: 10.1101/2025.02.18.638901. bioRxiv. 2025. PMID: 40027615 Free PMC article. Preprint.

7

Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency.

Chen J, Su S, Pickar-Oliver A, Chiarella AM, Hahn Q, Goldfarb D, Cloer EW, Small GW, Sivashankar S, Ramsden DA, Major MB, Hathaway NA, Gersbach CA, Liu P. Chen J, et al. Among authors: ramsden da. Nucleic Acids Res. 2024 Oct 28;52(19):11536-11551. doi: 10.1093/nar/gkae761. Nucleic Acids Res. 2024. PMID: 39228373 Free PMC article.

8

Sequential requirements for distinct Polθ domains during theta-mediated end joining.

Fijen C, Drogalis Beckham L, Terino D, Li Y, Ramsden DA, Wood RD, Doublié S, Rothenberg E. Fijen C, et al. Among authors: ramsden da. Mol Cell. 2024 Apr 18;84(8):1460-1474.e6. doi: 10.1016/j.molcel.2024.03.010. Mol Cell. 2024. PMID: 38640894 Free PMC article.

9

DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.

Kaminski AM, Chiruvella KK, Ramsden DA, Bebenek K, Kunkel TA, Pedersen LC. Kaminski AM, et al. Among authors: ramsden da. DNA Repair (Amst). 2024 Apr;136:103645. doi: 10.1016/j.dnarep.2024.103645. Epub 2024 Feb 3. DNA Repair (Amst). 2024. PMID: 38428373 Free PMC article.

10

Stepwise requirements for polymerases δ and θ in theta-mediated end joining.

Stroik S, Carvajal-Garcia J, Gupta D, Edwards A, Luthman A, Wyatt DW, Dannenberg RL, Feng W, Kunkel TA, Gupta GP, Hedglin M, Wood R, Doublié S, Rothenberg E, Ramsden DA. Stroik S, et al. Among authors: ramsden da. Nature. 2023 Nov;623(7988):836-841. doi: 10.1038/s41586-023-06729-7. Epub 2023 Nov 15. Nature. 2023. PMID: 37968395 Free PMC article.

11

Templated insertions-DNA repair gets acrobatic.

Stroik S, Luthman AJ, Ramsden DA. Stroik S, et al. Among authors: ramsden da. Environ Mol Mutagen. 2024 Apr;65 Suppl 1(Suppl 1):82-89. doi: 10.1002/em.22564. Epub 2023 Jul 28. Environ Mol Mutagen. 2024. PMID: 37438951 Free PMC article. Review.

12

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis.

Yang F, Su W, Chung OW, Tracy L, Wang L, Ramsden DA, Zhang ZZZ. Yang F, et al. Among authors: ramsden da. Nature. 2023 Aug;620(7972):218-225. doi: 10.1038/s41586-023-06327-7. Epub 2023 Jul 12. Nature. 2023. PMID: 37438532 Free PMC article.

13

Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection.

Luedeman ME, Stroik S, Feng W, Luthman AJ, Gupta GP, Ramsden DA. Luedeman ME, et al. Among authors: ramsden da. Nat Commun. 2022 Aug 4;13(1):4547. doi: 10.1038/s41467-022-32166-7. Nat Commun. 2022. PMID: 35927262 Free PMC article.

14

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining.

Kaminski AM, Chiruvella KK, Ramsden DA, Bebenek K, Kunkel TA, Pedersen LC. Kaminski AM, et al. Among authors: ramsden da. Nat Commun. 2022 Jul 1;13(1):3806. doi: 10.1038/s41467-022-31278-4. Nat Commun. 2022. PMID: 35778389 Free PMC article.

15

Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining.

Ramsden DA, Carvajal-Garcia J, Gupta GP. Ramsden DA, et al. Nat Rev Mol Cell Biol. 2022 Feb;23(2):125-140. doi: 10.1038/s41580-021-00405-2. Epub 2021 Sep 14. Nat Rev Mol Cell Biol. 2022. PMID: 34522048 Review.

16

Mechanisms driving chromosomal translocations: lost in time and space.

Ramsden DA, Nussenzweig A. Ramsden DA, et al. Oncogene. 2021 Jun;40(25):4263-4270. doi: 10.1038/s41388-021-01856-9. Epub 2021 Jun 8. Oncogene. 2021. PMID: 34103687 Free PMC article. Review.

17

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks.

Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Feng W, et al. Among authors: ramsden da. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. Nucleic Acids Res. 2021. PMID: 33963863 Free PMC article.

18

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.

Morton LM, Karyadi DM, Stewart C, Bogdanova TI, Dawson ET, Steinberg MK, Dai J, Hartley SW, Schonfeld SJ, Sampson JN, Maruvka YE, Kapoor V, Ramsden DA, Carvajal-Garcia J, Perou CM, Parker JS, Krznaric M, Yeager M, Boland JF, Hutchinson A, Hicks BD, Dagnall CL, Gastier-Foster JM, Bowen J, Lee O, Machiela MJ, Cahoon EK, Brenner AV, Mabuchi K, Drozdovitch V, Masiuk S, Chepurny M, Zurnadzhy LY, Hatch M, Berrington de Gonzalez A, Thomas GA, Tronko MD, Getz G, Chanock SJ. Morton LM, et al. Among authors: ramsden da. Science. 2021 May 14;372(6543):eabg2538. doi: 10.1126/science.abg2538. Epub 2021 Apr 22. Science. 2021. PMID: 33888599 Free PMC article.

19

DNA polymerase theta suppresses mitotic crossing over.

Carvajal-Garcia J, Crown KN, Ramsden DA, Sekelsky J. Carvajal-Garcia J, et al. Among authors: ramsden da. PLoS Genet. 2021 Mar 22;17(3):e1009267. doi: 10.1371/journal.pgen.1009267. eCollection 2021 Mar. PLoS Genet. 2021. PMID: 33750946 Free PMC article.

20

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.

Kumar RJ, Chao HX, Simpson DA, Feng W, Cho MG, Roberts VR, Sullivan AR, Shah SJ, Wozny AS, Fagan-Solis K, Kumar S, Luthman A, Ramsden DA, Purvis JE, Gupta GP. Kumar RJ, et al. Among authors: ramsden da. NAR Cancer. 2020 Dec;2(4):zcaa038. doi: 10.1093/narcan/zcaa038. Epub 2020 Dec 21. NAR Cancer. 2020. PMID: 33385162 Free PMC article.

21

The molecular basis and disease relevance of non-homologous DNA end joining.

Zhao B, Rothenberg E, Ramsden DA, Lieber MR. Zhao B, et al. Among authors: ramsden da. Nat Rev Mol Cell Biol. 2020 Dec;21(12):765-781. doi: 10.1038/s41580-020-00297-8. Epub 2020 Oct 19. Nat Rev Mol Cell Biol. 2020. PMID: 33077885 Free PMC article. Review.

22

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break.

Kaminski AM, Pryor JM, Ramsden DA, Kunkel TA, Pedersen LC, Bebenek K. Kaminski AM, et al. Among authors: ramsden da. Nat Commun. 2020 Sep 22;11(1):4784. doi: 10.1038/s41467-020-18506-5. Nat Commun. 2020. PMID: 32963245 Free PMC article.

23

Mechanistic basis for microhomology identification and genome scarring by polymerase theta.

Carvajal-Garcia J, Cho JE, Carvajal-Garcia P, Feng W, Wood RD, Sekelsky J, Gupta GP, Roberts SA, Ramsden DA. Carvajal-Garcia J, et al. Among authors: ramsden da. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8476-8485. doi: 10.1073/pnas.1921791117. Epub 2020 Mar 31. Proc Natl Acad Sci U S A. 2020. PMID: 32234782 Free PMC article.

24

Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.

Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B. Quiñones JL, et al. Among authors: ramsden da. DNA Repair (Amst). 2020 Mar;87:102773. doi: 10.1016/j.dnarep.2019.102773. Epub 2020 Jan 9. DNA Repair (Amst). 2020. PMID: 31945542 Free PMC article.

25

The Drosophila melanogaster Ortholog of RFWD3 Functions Independently of RAD51 During DNA Repair.

Carvajal-Garcia J, Gales ER, Ramsden DA, Sekelsky J. Carvajal-Garcia J, et al. Among authors: ramsden da. G3 (Bethesda). 2020 Mar 5;10(3):999-1004. doi: 10.1534/g3.119.400903. G3 (Bethesda). 2020. PMID: 31900333 Free PMC article.

26

Genetic determinants of cellular addiction to DNA polymerase theta.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Feng W, et al. Among authors: ramsden da. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. Nat Commun. 2019. PMID: 31537809 Free PMC article.

27

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.

Kaminski AM, Chiruvella KK, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC. Kaminski AM, et al. Among authors: ramsden da. Nucleic Acids Res. 2019 Sep 26;47(17):9410-9422. doi: 10.1093/nar/gkz680. Nucleic Acids Res. 2019. PMID: 31435651 Free PMC article.

28

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.

Pryor JM, Conlin MP, Carvajal-Garcia J, Luedeman ME, Luthman AJ, Small GW, Ramsden DA. Pryor JM, et al. Among authors: ramsden da. Science. 2018 Sep 14;361(6407):1126-1129. doi: 10.1126/science.aat2477. Science. 2018. PMID: 30213916 Free PMC article.

29

High-Throughput Analysis of DNA Break-Induced Chromosome Rearrangements by Amplicon Sequencing.

Brown AJ, Al-Soodani AT, Saul M, Her S, Garcia JC, Ramsden DA, Her C, Roberts SA. Brown AJ, et al. Among authors: ramsden da. Methods Enzymol. 2018;601:111-144. doi: 10.1016/bs.mie.2017.11.028. Epub 2018 Feb 21. Methods Enzymol. 2018. PMID: 29523230 Free PMC article.

30

Polμ tumor variants decrease the efficiency and accuracy of NHEJ.

Sastre-Moreno G, Pryor JM, Díaz-Talavera A, Ruiz JF, Ramsden DA, Blanco L. Sastre-Moreno G, et al. Among authors: ramsden da. Nucleic Acids Res. 2017 Sep 29;45(17):10018-10031. doi: 10.1093/nar/gkx625. Nucleic Acids Res. 2017. PMID: 28973441 Free PMC article.

31

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining.

Conlin MP, Reid DA, Small GW, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E. Conlin MP, et al. Among authors: ramsden da. Cell Rep. 2017 Sep 19;20(12):2810-2819. doi: 10.1016/j.celrep.2017.08.091. Cell Rep. 2017. PMID: 28930678 Free PMC article.

32

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC. Moon AF, et al. Among authors: ramsden da. Nucleic Acids Res. 2017 Sep 6;45(15):9138-9148. doi: 10.1093/nar/gkx527. Nucleic Acids Res. 2017. PMID: 28911097 Free PMC article.

33

Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.

Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA. Bellendir SP, et al. Among authors: ramsden da. Nucleic Acids Res. 2017 May 19;45(9):5333-5348. doi: 10.1093/nar/gkx214. Nucleic Acids Res. 2017. PMID: 28369583 Free PMC article.

34

Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.

Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF. Sastre-Moreno G, et al. Among authors: ramsden da. DNA Repair (Amst). 2017 Mar;51:31-45. doi: 10.1016/j.dnarep.2017.01.004. Epub 2017 Jan 17. DNA Repair (Amst). 2017. PMID: 28109743 Free PMC article.

35

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry.

Reid DA, Conlin MP, Yin Y, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E. Reid DA, et al. Among authors: ramsden da. Nucleic Acids Res. 2017 Feb 28;45(4):1872-1878. doi: 10.1093/nar/gkw1221. Nucleic Acids Res. 2017. PMID: 27924007 Free PMC article.

36

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.

Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA. Wyatt DW, et al. Among authors: ramsden da. Mol Cell. 2016 Aug 18;63(4):662-673. doi: 10.1016/j.molcel.2016.06.020. Epub 2016 Jul 21. Mol Cell. 2016. PMID: 27453047 Free PMC article.

37

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

Schellenberg MJ, Perera L, Strom CN, Waters CA, Monian B, Appel CD, Vilas CK, Williams JG, Ramsden DA, Williams RS. Schellenberg MJ, et al. Among authors: ramsden da. Nucleic Acids Res. 2016 May 5;44(8):3829-44. doi: 10.1093/nar/gkw228. Epub 2016 Apr 8. Nucleic Acids Res. 2016. PMID: 27060144 Free PMC article.

38

Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair.

Almohaini M, Chalasani SL, Bafail D, Akopiants K, Zhou T, Yannone SM, Ramsden DA, Hartman MCT, Povirk LF. Almohaini M, et al. Among authors: ramsden da. DNA Repair (Amst). 2016 May;41:16-26. doi: 10.1016/j.dnarep.2016.03.003. Epub 2016 Mar 24. DNA Repair (Amst). 2016. PMID: 27049455 Free PMC article.

39

Essential role for polymerase specialization in cellular nonhomologous end joining.

Pryor JM, Waters CA, Aza A, Asagoshi K, Strom C, Mieczkowski PA, Blanco L, Ramsden DA. Pryor JM, et al. Among authors: ramsden da. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4537-45. doi: 10.1073/pnas.1505805112. Epub 2015 Aug 3. Proc Natl Acad Sci U S A. 2015. PMID: 26240371 Free PMC article.

40

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP. Wilson JE, et al. Among authors: ramsden da. Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24. Nat Med. 2015. PMID: 26107252 Free PMC article.

41

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E. Reid DA, et al. Among authors: ramsden da. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2575-84. doi: 10.1073/pnas.1420115112. Epub 2015 May 4. Proc Natl Acad Sci U S A. 2015. PMID: 25941401 Free PMC article.

42

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD. Yousefzadeh MJ, et al. Among authors: ramsden da. PLoS Genet. 2014 Oct 2;10(10):e1004654. doi: 10.1371/journal.pgen.1004654. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25275444 Free PMC article.

43

Requirements for 5'dRP/AP lyase activity in Ku.

Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA. Strande NT, et al. Among authors: ramsden da. Nucleic Acids Res. 2014;42(17):11136-43. doi: 10.1093/nar/gku796. Epub 2014 Sep 8. Nucleic Acids Res. 2014. PMID: 25200085 Free PMC article.

44

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining.

Waters CA, Strande NT, Pryor JM, Strom CN, Mieczkowski P, Burkhalter MD, Oh S, Qaqish BF, Moore DT, Hendrickson EA, Ramsden DA. Waters CA, et al. Among authors: ramsden da. Nat Commun. 2014 Jul 3;5:4286. doi: 10.1038/ncomms5286. Nat Commun. 2014. PMID: 24989324 Free PMC article.

45

Nonhomologous end joining: a good solution for bad ends.

Waters CA, Strande NT, Wyatt DW, Pryor JM, Ramsden DA. Waters CA, et al. Among authors: ramsden da. DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14. DNA Repair (Amst). 2014. PMID: 24630899 Free PMC article. Review.

46

Sustained active site rigidity during synthesis by human DNA polymerase μ.

Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, Pedersen LC. Moon AF, et al. Among authors: ramsden da. Nat Struct Mol Biol. 2014 Mar;21(3):253-60. doi: 10.1038/nsmb.2766. Epub 2014 Feb 2. Nat Struct Mol Biol. 2014. PMID: 24487959 Free PMC article.

47

Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.

Mohapatra S, Yannone SM, Lee SH, Hromas RA, Akopiants K, Menon V, Ramsden DA, Povirk LF. Mohapatra S, et al. Among authors: ramsden da. DNA Repair (Amst). 2013 Jun 1;12(6):422-32. doi: 10.1016/j.dnarep.2013.03.005. Epub 2013 Apr 18. DNA Repair (Amst). 2013. PMID: 23602515 Free PMC article.

48

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

Strande NT, Waters CA, Ramsden DA. Strande NT, et al. Among authors: ramsden da. Genome Integr. 2012 Dec 31;3(1):10. doi: 10.1186/2041-9414-3-10. Genome Integr. 2012. PMID: 23276302 Free PMC article.

49

Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS. Schellenberg MJ, et al. Among authors: ramsden da. Nat Struct Mol Biol. 2012 Dec;19(12):1363-71. doi: 10.1038/nsmb.2418. Epub 2012 Oct 28. Nat Struct Mol Biol. 2012. PMID: 23104055 Free PMC article.

50

DNA polymerases in nonhomologous end joining: are there any benefits to standing out from the crowd?

Ramsden DA, Asagoshi K. Ramsden DA, et al. Environ Mol Mutagen. 2012 Dec;53(9):741-51. doi: 10.1002/em.21725. Epub 2012 Sep 18. Environ Mol Mutagen. 2012. PMID: 22987211 Review.

51

Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.

Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA. Strande N, et al. Among authors: ramsden da. J Biol Chem. 2012 Apr 20;287(17):13686-93. doi: 10.1074/jbc.M111.329730. Epub 2012 Feb 23. J Biol Chem. 2012. PMID: 22362780 Free PMC article.

52

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M. Mani RS, et al. Among authors: ramsden da. J Biol Chem. 2010 Nov 26;285(48):37619-29. doi: 10.1074/jbc.M109.058719. Epub 2010 Sep 17. J Biol Chem. 2010. PMID: 20852255 Free PMC article.

53

Polymerases in nonhomologous end joining: building a bridge over broken chromosomes.

Ramsden DA. Ramsden DA. Antioxid Redox Signal. 2011 Jun 15;14(12):2509-19. doi: 10.1089/ars.2010.3429. Epub 2010 Oct 28. Antioxid Redox Signal. 2011. PMID: 20649463 Free PMC article. Review.

54

V(D)J recombination: Born to be wild.

Ramsden DA, Weed BD, Reddy YV. Ramsden DA, et al. Semin Cancer Biol. 2010 Aug;20(4):254-60. doi: 10.1016/j.semcancer.2010.06.002. Epub 2010 Jul 1. Semin Cancer Biol. 2010. PMID: 20600921 Free PMC article. Review.

55

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.

Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA. Roberts SA, et al. Among authors: ramsden da. Nature. 2010 Apr 22;464(7292):1214-7. doi: 10.1038/nature08926. Epub 2010 Apr 11. Nature. 2010. PMID: 20383123 Free PMC article.

56

Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks.

Burkhalter MD, Roberts SA, Havener JM, Ramsden DA. Burkhalter MD, et al. Among authors: ramsden da. DNA Repair (Amst). 2009 Nov 2;8(11):1258-63. doi: 10.1016/j.dnarep.2009.07.009. Epub 2009 Aug 26. DNA Repair (Amst). 2009. PMID: 19713159 Free PMC article.

57

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

Garcia-Diaz M, Bebenek K, Larrea AA, Havener JM, Perera L, Krahn JM, Pedersen LC, Ramsden DA, Kunkel TA. Garcia-Diaz M, et al. Among authors: ramsden da. Nat Struct Mol Biol. 2009 Sep;16(9):967-72. doi: 10.1038/nsmb.1654. Epub 2009 Aug 23. Nat Struct Mol Biol. 2009. PMID: 19701199 Free PMC article.

58

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. Zhou T, et al. Among authors: ramsden da. DNA Repair (Amst). 2009 Aug 6;8(8):901-11. doi: 10.1016/j.dnarep.2009.05.003. Epub 2009 Jun 7. DNA Repair (Amst). 2009. PMID: 19505854 Free PMC article.

59

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand.

Bukowy Z, Harrigan JA, Ramsden DA, Tudek B, Bohr VA, Stevnsner T. Bukowy Z, et al. Among authors: ramsden da. Nucleic Acids Res. 2008 Sep;36(15):4975-87. doi: 10.1093/nar/gkn468. Epub 2008 Jul 25. Nucleic Acids Res. 2008. PMID: 18658245 Free PMC article.

60

A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda.

Mueller GA, Moon AF, Derose EF, Havener JM, Ramsden DA, Pedersen LC, London RE. Mueller GA, et al. Among authors: ramsden da. DNA Repair (Amst). 2008 Aug 2;7(8):1340-51. doi: 10.1016/j.dnarep.2008.04.018. Epub 2008 Jun 26. DNA Repair (Amst). 2008. PMID: 18585102 Free PMC article.

61

End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining.

Davis BJ, Havener JM, Ramsden DA. Davis BJ, et al. Among authors: ramsden da. Nucleic Acids Res. 2008 May;36(9):3085-94. doi: 10.1093/nar/gkn164. Epub 2008 Apr 8. Nucleic Acids Res. 2008. PMID: 18397950 Free PMC article.

62

Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.

DeRose EF, Clarkson MW, Gilmore SA, Galban CJ, Tripathy A, Havener JM, Mueller GA, Ramsden DA, London RE, Lee AL. DeRose EF, et al. Among authors: ramsden da. Biochemistry. 2007 Oct 30;46(43):12100-10. doi: 10.1021/bi7007728. Epub 2007 Oct 4. Biochemistry. 2007. PMID: 17915942 Free PMC article.

63

Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts.

Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Povirk LF, et al. Among authors: ramsden da. Nucleic Acids Res. 2007;35(12):3869-78. doi: 10.1093/nar/gkm339. Epub 2007 May 25. Nucleic Acids Res. 2007. PMID: 17526517 Free PMC article.

64

Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends.

Roberts SA, Ramsden DA. Roberts SA, et al. Among authors: ramsden da. J Biol Chem. 2007 Apr 6;282(14):10605-13. doi: 10.1074/jbc.M611125200. Epub 2007 Feb 8. J Biol Chem. 2007. PMID: 17289670 Free article.

65

Structural insight into the substrate specificity of DNA Polymerase mu.

Moon AF, Garcia-Diaz M, Bebenek K, Davis BJ, Zhong X, Ramsden DA, Kunkel TA, Pedersen LC. Moon AF, et al. Among authors: ramsden da. Nat Struct Mol Biol. 2007 Jan;14(1):45-53. doi: 10.1038/nsmb1180. Epub 2006 Dec 10. Nat Struct Mol Biol. 2007. PMID: 17159995

66

Genomic instability due to V(D)J recombination-associated transposition.

Reddy YV, Perkins EJ, Ramsden DA. Reddy YV, et al. Among authors: ramsden da. Genes Dev. 2006 Jun 15;20(12):1575-82. doi: 10.1101/gad.1432706. Genes Dev. 2006. PMID: 16778076 Free PMC article.

67

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juárez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA. Nick McElhinny SA, et al. Among authors: ramsden da. Mol Cell. 2005 Aug 5;19(3):357-66. doi: 10.1016/j.molcel.2005.06.012. Mol Cell. 2005. PMID: 16061182 Free article.

68

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA. Reddy YV, et al. Among authors: ramsden da. J Biol Chem. 2004 Sep 17;279(38):39408-13. doi: 10.1074/jbc.M406432200. Epub 2004 Jul 15. J Biol Chem. 2004. PMID: 15258142 Free article.

69

Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair.

Nick McElhinny SA, Ramsden DA. Nick McElhinny SA, et al. Among authors: ramsden da. Immunol Rev. 2004 Aug;200:156-64. doi: 10.1111/j.0105-2896.2004.00160.x. Immunol Rev. 2004. PMID: 15242403 Review.

70

The DNA-dependent protein kinase: the director at the end.

Meek K, Gupta S, Ramsden DA, Lees-Miller SP. Meek K, et al. Among authors: ramsden da. Immunol Rev. 2004 Aug;200:132-41. doi: 10.1111/j.0105-2896.2004.00162.x. Immunol Rev. 2004. PMID: 15242401 Review.

71

Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.

Perkins EJ, Kee BL, Ramsden DA. Perkins EJ, et al. Among authors: ramsden da. Nucleic Acids Res. 2004 Mar 29;32(6):1942-7. doi: 10.1093/nar/gkh523. Print 2004. Nucleic Acids Res. 2004. PMID: 15051812 Free PMC article.

72

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K. Ding Q, et al. Among authors: ramsden da. Mol Cell Biol. 2003 Aug;23(16):5836-48. doi: 10.1128/MCB.23.16.5836-5848.2003. Mol Cell Biol. 2003. PMID: 12897153 Free PMC article.

73

Polymerase mu is a DNA-directed DNA/RNA polymerase.

Nick McElhinny SA, Ramsden DA. Nick McElhinny SA, et al. Among authors: ramsden da. Mol Cell Biol. 2003 Apr;23(7):2309-15. doi: 10.1128/MCB.23.7.2309-2315.2003. Mol Cell Biol. 2003. PMID: 12640116 Free PMC article.

74

Translesion synthesis past platinum DNA adducts by human DNA polymerase mu.

Havener JM, Nick McElhinny SA, Bassett E, Gauger M, Ramsden DA, Chaney SG. Havener JM, et al. Among authors: ramsden da. Biochemistry. 2003 Feb 18;42(6):1777-88. doi: 10.1021/bi0270079. Biochemistry. 2003. PMID: 12578393

75

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.

Karmakar P, Snowden CM, Ramsden DA, Bohr VA. Karmakar P, et al. Among authors: ramsden da. Nucleic Acids Res. 2002 Aug 15;30(16):3583-91. doi: 10.1093/nar/gkf482. Nucleic Acids Res. 2002. PMID: 12177300 Free PMC article.

76

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.

Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA. Mahajan KN, et al. Among authors: ramsden da. Mol Cell Biol. 2002 Jul;22(14):5194-202. doi: 10.1128/MCB.22.14.5194-5202.2002. Mol Cell Biol. 2002. PMID: 12077346 Free PMC article.

77

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.

Karmakar P, Piotrowski J, Brosh RM Jr, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA. Karmakar P, et al. Among authors: ramsden da. J Biol Chem. 2002 May 24;277(21):18291-302. doi: 10.1074/jbc.M111523200. Epub 2002 Mar 11. J Biol Chem. 2002. PMID: 11889123 Free article.

78

Sensing of intermediates in V(D)J recombination by ATM.

Perkins EJ, Nair A, Cowley DO, Van Dyke T, Chang Y, Ramsden DA. Perkins EJ, et al. Among authors: ramsden da. Genes Dev. 2002 Jan 15;16(2):159-64. doi: 10.1101/gad.956902. Genes Dev. 2002. PMID: 11799059 Free PMC article.

79

V(D)J recombination: links to transposition and double-strand break repair.

Gellert M, Hesse JE, Hiom K, Melek M, Modesti M, Paull TT, Ramsden DA, van Gent DC. Gellert M, et al. Among authors: ramsden da. Cold Spring Harb Symp Quant Biol. 1999;64:161-7. doi: 10.1101/sqb.1999.64.161. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232281 Review. No abstract available.

80

Ku recruits the XRCC4-ligase IV complex to DNA ends.

Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA. Nick McElhinny SA, et al. Among authors: ramsden da. Mol Cell Biol. 2000 May;20(9):2996-3003. doi: 10.1128/MCB.20.9.2996-3003.2000. Mol Cell Biol. 2000. PMID: 10757784 Free PMC article.

81

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks.

Ramsden DA, Gellert M. Ramsden DA, et al. EMBO J. 1998 Jan 15;17(2):609-14. doi: 10.1093/emboj/17.2.609. EMBO J. 1998. PMID: 9430651 Free PMC article.

82

Cell-free V(D)J recombination.

Ramsden DA, Paull TT, Gellert M. Ramsden DA, et al. Nature. 1997 Jul 31;388(6641):488-91. doi: 10.1038/41351. Nature. 1997. PMID: 9242409

83

Specificity in V(D)J recombination: new lessons from biochemistry and genetics.

Ramsden DA, van Gent DC, Gellert M. Ramsden DA, et al. Curr Opin Immunol. 1997 Feb;9(1):114-20. doi: 10.1016/s0952-7915(97)80167-7. Curr Opin Immunol. 1997. PMID: 9039786 Free article. Review.

84

Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.

Ramsden DA, McBlane JF, van Gent DC, Gellert M. Ramsden DA, et al. EMBO J. 1996 Jun 17;15(12):3197-206. EMBO J. 1996. PMID: 8670820 Free PMC article.

85

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination.

van Gent DC, Ramsden DA, Gellert M. van Gent DC, et al. Among authors: ramsden da. Cell. 1996 Apr 5;85(1):107-13. doi: 10.1016/s0092-8674(00)81086-7. Cell. 1996. PMID: 8620529 Free article.

86

Initiation of V(D)J recombinations in a cell-free system by RAG1 and RAG2 proteins.

van Gent DC, McBlane JF, Ramsden DA, Sadofsky MJ, Hesse JE, Gellert M. van Gent DC, et al. Among authors: ramsden da. Curr Top Microbiol Immunol. 1996;217:1-10. doi: 10.1007/978-3-642-50140-1_1. Curr Top Microbiol Immunol. 1996. PMID: 8787614 Review. No abstract available.

87

Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558.

Connor AM, Fanning LJ, Celler JW, Hicks LK, Ramsden DA, Wu GE. Connor AM, et al. Among authors: ramsden da. J Immunol. 1995 Dec 1;155(11):5268-72. J Immunol. 1995. PMID: 7594539

88

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. McBlane JF, et al. Among authors: ramsden da. Cell. 1995 Nov 3;83(3):387-95. doi: 10.1016/0092-8674(95)90116-7. Cell. 1995. PMID: 8521468 Free article.

89

Formation and resolution of double-strand break intermediates in V(D)J rearrangement.

Ramsden DA, Gellert M. Ramsden DA, et al. Genes Dev. 1995 Oct 1;9(19):2409-20. doi: 10.1101/gad.9.19.2409. Genes Dev. 1995. PMID: 7557392 Free article.

90

Initiation of V(D)J recombination in a cell-free system.

van Gent DC, McBlane JF, Ramsden DA, Sadofsky MJ, Hesse JE, Gellert M. van Gent DC, et al. Among authors: ramsden da. Cell. 1995 Jun 16;81(6):925-34. doi: 10.1016/0092-8674(95)90012-8. Cell. 1995. PMID: 7781069 Free article.

91

Three new immunoglobulin kappa variable (Igk-V) gene segments in the mouse.

Ramsden DA, Wu GE. Ramsden DA, et al. Immunogenetics. 1995;41(5):334. doi: 10.1007/BF00172163. Immunogenetics. 1995. PMID: 7721360 No abstract available.

92

Kappa light chain rearrangement in mouse fetal liver.

Ramsden DA, Paige CJ, Wu GE. Ramsden DA, et al. J Immunol. 1994 Aug 1;153(3):1150-60. J Immunol. 1994. PMID: 8027546

93

Conservation of sequence in recombination signal sequence spacers.

Ramsden DA, Baetz K, Wu GE. Ramsden DA, et al. Nucleic Acids Res. 1994 May 25;22(10):1785-96. doi: 10.1093/nar/22.10.1785. Nucleic Acids Res. 1994. PMID: 8208601 Free PMC article.

94

Development of B lymphocytes from lymphoid committed and uncommitted progenitors.

Cumano A, Kee BL, Ramsden DA, Marshall A, Paige CJ, Wu GE. Cumano A, et al. Among authors: ramsden da. Immunol Rev. 1994 Feb;137:5-33. doi: 10.1111/j.1600-065x.1994.tb00657.x. Immunol Rev. 1994. PMID: 8034337 Review. No abstract available.

95

The virgin B cell K:lambda ratio.

Ramsden DA, Wu GE. Ramsden DA, et al. Res Immunol. 1992 Oct;143(8):811-7; discussion 830-9. doi: 10.1016/0923-2494(92)80096-4. Res Immunol. 1992. PMID: 1287761 No abstract available.

96

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.

Ramsden DA, Wu GE. Ramsden DA, et al. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10721-5. doi: 10.1073/pnas.88.23.10721. Proc Natl Acad Sci U S A. 1991. PMID: 1961738 Free PMC article.

97

VH gene repertoire.

Wu GE, Atkinson MJ, Ramsden DA, Paige CJ. Wu GE, et al. Among authors: ramsden da. Semin Immunol. 1990 May;2(3):207-16. Semin Immunol. 1990. PMID: 2129908 Review.

98

Epitope mapping of the cloned human autoantigen, histidyl-tRNA synthetase. Analysis of the myositis-associated anti-Jo-1 autoimmune response.

Ramsden DA, Chen J, Miller FW, Misener V, Bernstein RM, Siminovitch KA, Tsui FW. Ramsden DA, et al. J Immunol. 1989 Oct 1;143(7):2267-72. J Immunol. 1989. PMID: 2476503

99

Gastric cancer. Contemporary aspects.

Cady B, Ramsden DA, Stein A, Haggitt RC. Cady B, et al. Among authors: ramsden da. Am J Surg. 1977 Apr;133(4):423-9. doi: 10.1016/0002-9610(77)90126-x. Am J Surg. 1977. PMID: 848677

100

Treatment of gastric cancer.

Cady B, Ramsden DA, Choe DS. Cady B, et al. Among authors: ramsden da. Surg Clin North Am. 1976 Jun;56(3):599-605. doi: 10.1016/s0039-6109(16)40935-7. Surg Clin North Am. 1976. PMID: 936013 No abstract available.

101

Severe pseudomembranous colitis after lincomycin and clindamycin.

Smart RF, Ramsden DA, Gear MW, Nicol A, Lennox WM. Smart RF, et al. Among authors: ramsden da. Br J Surg. 1976 Jan;63(1):25-9. doi: 10.1002/bjs.1800630106. Br J Surg. 1976. PMID: 1267870

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