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Randomised trial of the effect of a gastrin/CCK(2) receptor antagonist on esomeprazole-induced hypergastrinaemia: evidence against rebound hyperacidity.
Boyce M, van den Berg F, Mitchell T, Darwin K, Warrington S. Boyce M, et al. Eur J Clin Pharmacol. 2017 Feb;73(2):129-139. doi: 10.1007/s00228-016-2150-x. Epub 2016 Oct 29. Eur J Clin Pharmacol. 2017. PMID: 27796466 Clinical Trial.
Esomeprazole-induced hypergastrinaemia stimulates ECL cells and thereby increases CgA. Netazepide-induced hypergastrinaemia does not increase CgA, because netazepide blocks gastrin/CCK(2) receptors on ECL cells. Co-administration of netazepide 5 …
Esomeprazole-induced hypergastrinaemia stimulates ECL cells and thereby increases CgA. Netazepide-induced hypergastr …