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Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. Sussan TE, et al. Among authors: rangasamy t. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. doi: 10.1073/pnas.0804333106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2009. PMID: 19104057 Free PMC article.
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Yoshida T, et al. Among authors: rangasamy t. Nat Med. 2010 Jul;16(7):767-73. doi: 10.1038/nm.2157. Epub 2010 May 16. Nat Med. 2010. PMID: 20473305 Free PMC article.
Impaired lung homeostasis in neonatal mice exposed to cigarette smoke.
McGrath-Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, Tuder RM, Biswal S. McGrath-Morrow S, et al. Among authors: rangasamy t. Am J Respir Cell Mol Biol. 2008 Apr;38(4):393-400. doi: 10.1165/rcmb.2007-0104OC. Epub 2007 Nov 1. Am J Respir Cell Mol Biol. 2008. PMID: 17975176 Free PMC article.
Cell stiffness, contractile stress and the role of extracellular matrix.
An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, Biswal S. An SS, et al. Among authors: rangasamy t. Biochem Biophys Res Commun. 2009 May 15;382(4):697-703. doi: 10.1016/j.bbrc.2009.03.118. Epub 2009 Mar 25. Biochem Biophys Res Commun. 2009. PMID: 19327344 Free PMC article.
21 results