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Regulation of gene expression in peripheral T cells by Runx transcription factors.
Djuretic IM, Cruz-Guilloty F, Rao A. Djuretic IM, et al. Adv Immunol. 2009;104:1-23. doi: 10.1016/S0065-2776(08)04001-7. Epub 2009 Dec 1. Adv Immunol. 2009. PMID: 20457114 Review.
Members of the Runx family of transcription factors, Runx1-3, are essential regulators of the immune system: a deficiency in one of the members, Runx1, results in complete ablation of hematopoiesis, and all three Runx proteins play important, nonredundant roles in immune s …
Members of the Runx family of transcription factors, Runx1-3, are essential regulators of the immune system: a deficiency in one of t …
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A. Pipkin ME, et al. Immunity. 2010 Jan 29;32(1):79-90. doi: 10.1016/j.immuni.2009.11.012. Epub 2010 Jan 21. Immunity. 2010. PMID: 20096607 Free PMC article.
We demonstrate a complex interplay between IL-2 and inflammatory signals during CTL differentiation. IL-2 stimulation induced the transcription factor eomesodermin (Eomes), upregulated perforin (Prf1) transcription, and repressed re-expression of memory CTL markers Bcl6 an …
We demonstrate a complex interplay between IL-2 and inflammatory signals during CTL differentiation. IL-2 stimulation induced the tra …
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. Martinez GJ, et al. Immunity. 2015 Feb 17;42(2):265-278. doi: 10.1016/j.immuni.2015.01.006. Epub 2015 Feb 10. Immunity. 2015. PMID: 25680272 Free PMC article.
During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. ...
During persistent antigen stimulation, CD8(+) T cells show a gradual decrease in effector function, referred to as exhaustion, which …
Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.
Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L. Bandukwala HS, et al. Immunity. 2011 Apr 22;34(4):479-91. doi: 10.1016/j.immuni.2011.02.017. Epub 2011 Mar 31. Immunity. 2011. PMID: 21458306 Free PMC article.
We have solved the crystal structure of the FOXP3 forkhead domain as a ternary complex with the DNA-binding domain of the transcription factor NFAT1 and a DNA oligonucleotide from the interleukin-2 promoter. A striking feature of this structure is that FOXP3 …
We have solved the crystal structure of the FOXP3 forkhead domain as a ternary complex with the DNA-binding domain of the transcripti …
A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.
Fehr T, Lucas CL, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. Fehr T, et al. Blood. 2010 Feb 11;115(6):1280-7. doi: 10.1182/blood-2009-07-230680. Epub 2009 Dec 10. Blood. 2010. PMID: 20007805 Free PMC article.
Calcineurin blockade by cyclosporine A led to a failure of CD8 but not CD4 tolerance, and experiments in NFAT1(-/-) mice replicated this effect. ...Thus, our study reveals a CD8 T cell-intrinsic NFAT1 requirement for CD8 tolerance in vivo....
Calcineurin blockade by cyclosporine A led to a failure of CD8 but not CD4 tolerance, and experiments in NFAT1(-/-) mice repli …
Calcium signaling in cells of the immune and hematopoietic systems.
Rao A, Hogan PG. Rao A, et al. Immunol Rev. 2009 Sep;231(1):5-9. doi: 10.1111/j.1600-065X.2009.00823.x. Immunol Rev. 2009. PMID: 19754886 No abstract available.
SnapShot: effector and memory T cell differentiation.
Pipkin ME, Rao A. Pipkin ME, et al. Cell. 2009 Aug 7;138(3):606.e1-2. doi: 10.1016/j.cell.2009.07.020. Cell. 2009. PMID: 19665979 Free PMC article. No abstract available.
Orphans against autoimmunity.
Bandukwala H, Sundrud MS, Rao A. Bandukwala H, et al. Immunity. 2008 Aug 15;29(2):167-8. doi: 10.1016/j.immuni.2008.07.008. Immunity. 2008. PMID: 18701076
In this issue of Immunity, Hermann-Kleiter et al. (2008) identify a nuclear orphan receptor, NR2F6, as a negative regulator of the T helper 17 cell subset and report that NR2F6-deficient mice develop late-onset autoimmune disease....
In this issue of Immunity, Hermann-Kleiter et al. (2008) identify a nuclear orphan receptor, NR2F6, as a negative regulator of …
Gene regulation and signal transduction in the immune system.
Horng T, Oberdoerffer S, Rao A. Horng T, et al. Genome Biol. 2008;9(7):315. doi: 10.1186/gb-2008-9-7-315. Epub 2008 Jul 10. Genome Biol. 2008. PMID: 18644102 Free PMC article.
A report of the meeting 'Gene Expression and Signaling in the Immune System', Cold Spring Harbor, USA, 22-26 April 2008....
A report of the meeting 'Gene Expression and Signaling in the Immune System', Cold Spring Harbor, USA, 22-26 April 2008....
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