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Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation.
Sun Q, Zheng Y, Liu Q, Cao X. Sun Q, et al. Int Immunopharmacol. 2008 Dec 20;8(13-14):1854-8. doi: 10.1016/j.intimp.2008.08.009. Epub 2008 Sep 21. Int Immunopharmacol. 2008. PMID: 18789402
However, the underlying mechanisms responsible for antitumor effects of rapamycin remain to be fully elucidated. Here we report that rapamycin can reverse TLR4-triggered resistance of colon cancer cells to oxaloplatin- or doxorubicin-induced …
However, the underlying mechanisms responsible for antitumor effects of rapamycin remain to be fully elucidated. Here we report that …