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Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation.
Sun Q, Liu Q, Zheng Y, Cao X. Sun Q, et al. Mol Immunol. 2008 May;45(10):2929-36. doi: 10.1016/j.molimm.2008.01.025. Epub 2008 Mar 17. Mol Immunol. 2008. PMID: 18343502
In the present study, we demonstrate that rapamycin can significantly inhibit TLR4-triggered IL-6 and PGE(2) production and invasion of colon cancer cells. ...Furthermore, disruption of NF-kappaB …
In the present study, we demonstrate that rapamycin can significantly inhibit TLR4-triggered IL-6 …