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Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression.
Raposinho PD, Pedrazzini T, White RB, Palmiter RD, Aubert ML. Raposinho PD, et al. Endocrinology. 2004 Jan;145(1):304-10. doi: 10.1210/en.2003-0914. Epub 2003 Oct 2. Endocrinology. 2004. PMID: 14525913
Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism.
Raposinho PD, Pierroz DD, Broqua P, White RB, Pedrazzini T, Aubert ML. Raposinho PD, et al. Mol Cell Endocrinol. 2001 Dec 20;185(1-2):195-204. doi: 10.1016/s0303-7207(01)00620-7. Mol Cell Endocrinol. 2001. PMID: 11738809
Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes.
Raposinho PD, Castillo E, d'Alleves V, Broqua P, Pralong FP, Aubert ML. Raposinho PD, et al. Endocrinology. 2000 Dec;141(12):4419-27. doi: 10.1210/endo.141.12.7842. Endocrinology. 2000. PMID: 11108250
Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype.
Raposinho PD, Broqua P, Pierroz DD, Hayward A, Dumont Y, Quirion R, Junien JL, Aubert ML. Raposinho PD, et al. Endocrinology. 1999 Sep;140(9):4046-55. doi: 10.1210/endo.140.9.6985. Endocrinology. 1999. PMID: 10465275
Stimulation of the gonadotropic axis by the neuropeptide Y receptor Y1 antagonist/Y4 agonist 1229U91 in the male rat.
Raposinho PD, Broqua P, Hayward A, Akinsanya K, Galyean R, Schteingart C, Junien J, Aubert ML. Raposinho PD, et al. Neuroendocrinology. 2000 Jan;71(1):2-7. doi: 10.1159/000054514. Neuroendocrinology. 2000. PMID: 10644893
Obesity and the reproductive axis.
Pralong FP, Castillo E, Raposinho PD, Aubert ML, Gaillard RC. Pralong FP, et al. Among authors: raposinho pd. Ann Endocrinol (Paris). 2002 Apr;63(2 Pt 1):129-34. Ann Endocrinol (Paris). 2002. PMID: 11994676 Review. No abstract available.
The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat.
Raposinho PD, White RB, Aubert ML. Raposinho PD, et al. J Neuroendocrinol. 2003 Feb;15(2):173-81. doi: 10.1046/j.1365-2826.2003.00962.x. J Neuroendocrinol. 2003. PMID: 12535159
[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX.
Can D, Spingler B, Schmutz P, Mendes F, Raposinho P, Fernandes C, Carta F, Innocenti A, Santos I, Supuran CT, Alberto R. Can D, et al. Among authors: raposinho p. Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3354-7. doi: 10.1002/anie.201107333. Epub 2012 Feb 17. Angew Chem Int Ed Engl. 2012. PMID: 22344779
The [(Cp)M(CO)(3)] (M=Re, (99m)Tc) building block for imaging agents and bioinorganic probes: perspectives and limitations.
Can D, Peindy N'Dongo HW, Spingler B, Schmutz P, Raposinho P, Santos I, Alberto R. Can D, et al. Among authors: raposinho p. Chem Biodivers. 2012 Sep;9(9):1849-66. doi: 10.1002/cbdv.201200076. Chem Biodivers. 2012. PMID: 22976975
Towards (99m)Tc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study.
Imstepf S, Pierroz V, Raposinho P, Felber M, Fox T, Fernandes C, Gasser G, Santos IR, Alberto R. Imstepf S, et al. Among authors: raposinho p. Dalton Trans. 2016 Aug 16;45(33):13025-33. doi: 10.1039/c6dt00871b. Dalton Trans. 2016. PMID: 27097328
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