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Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC. Brondfield S, et al. Among authors: rappaport ar. Cancer Chemother Pharmacol. 2015 Jul;76(1):35-46. doi: 10.1007/s00280-015-2766-z. Epub 2015 May 9. Cancer Chemother Pharmacol. 2015. PMID: 25956709 Free PMC article.
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR. Zuber J, et al. Among authors: rappaport ar. Nature. 2011 Aug 3;478(7370):524-8. doi: 10.1038/nature10334. Nature. 2011. PMID: 21814200 Free PMC article.
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.
Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW. Chen C, et al. Among authors: rappaport ar. Cancer Cell. 2014 May 12;25(5):652-65. doi: 10.1016/j.ccr.2014.03.016. Epub 2014 May 1. Cancer Cell. 2014. PMID: 24794707 Free PMC article.
Mouse models of human AML accurately predict chemotherapy response.
Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW. Zuber J, et al. Genes Dev. 2009 Apr 1;23(7):877-89. doi: 10.1101/gad.1771409. Genes Dev. 2009. PMID: 19339691 Free PMC article.
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, Powers S, Wigler M, Lowe SW. Xue W, et al. Among authors: rappaport ar. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8212-7. doi: 10.1073/pnas.1206062109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566646 Free PMC article.
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