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Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies.
Del Papa N, Sheng YH, Raschi E, Kandiah DA, Tincani A, Khamashta MA, Atsumi T, Hughes GR, Ichikawa K, Koike T, Balestrieri G, Krilis SA, Meroni PL. Del Papa N, et al. Among authors: raschi e. J Immunol. 1998 Jun 1;160(11):5572-8. J Immunol. 1998. PMID: 9605162
Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I.
Di Simone N, Meroni PL, de Papa N, Raschi E, Caliandro D, De Carolis CS, Khamashta MA, Atsumi T, Hughes GR, Balestrieri G, Tincani A, Casali P, Caruso A. Di Simone N, et al. Among authors: raschi e. Arthritis Rheum. 2000 Jan;43(1):140-50. doi: 10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P. Arthritis Rheum. 2000. PMID: 10643710 Free PMC article.
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