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Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.
Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, Lambeau G. Rouault M, et al. Among authors: rash ld. Biochemistry. 2006 May 9;45(18):5800-16. doi: 10.1021/bi060217r. Biochemistry. 2006. PMID: 16669624 Free PMC article.
Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.
Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD. Jensen JE, et al. Among authors: rash ld. J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4. J Med Chem. 2014. PMID: 25337890
54 results