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New insights into the structure of PINK1 and the mechanism of ubiquitin phosphorylation.
Rasool S, Trempe JF. Rasool S, et al. Crit Rev Biochem Mol Biol. 2018 Oct;53(5):515-534. doi: 10.1080/10409238.2018.1491525. Epub 2018 Sep 21. Crit Rev Biochem Mol Biol. 2018. PMID: 30238821 Review.
Mutations in PINK1 cause early-onset recessive Parkinson's disease. This gene encodes a protein kinase implicated in mitochondrial quality control via ubiquitin phosphorylation and activation of the E3 ubiquitin ligase Parkin. ...
Mutations in PINK1 cause early-onset recessive Parkinson's disease. This gene encodes a protein kinase implicated in mitochondrial qu …
A Ubl/ubiquitin switch in the activation of Parkin.
Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. Sauvé V, et al. Among authors: rasool s. EMBO J. 2015 Oct 14;34(20):2492-505. doi: 10.15252/embj.201592237. Epub 2015 Aug 7. EMBO J. 2015. PMID: 26254305 Free PMC article.
Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mitochondrial quality control pathway whereby PINK1 accumulates on damaged mitochondria and activates Parkin to induce mitophagy. ...
Mutations in Parkin and PINK1 cause an inherited early-onset form of Parkinson's disease. The two proteins function together in a mit …
PINK1 autophosphorylation is required for ubiquitin recognition.
Rasool S, Soya N, Truong L, Croteau N, Lukacs GL, Trempe JF. Rasool S, et al. EMBO Rep. 2018 Apr;19(4):e44981. doi: 10.15252/embr.201744981. Epub 2018 Feb 23. EMBO Rep. 2018. PMID: 29475881 Free PMC article.
Mutations in PINK1 cause autosomal recessive Parkinson's disease (PD), a neurodegenerative movement disorder. PINK1 is a kinase that acts as a sensor of mitochondrial damage and initiates Parkin-mediated clearance of the damaged organelle. ...
Mutations in PINK1 cause autosomal recessive Parkinson's disease (PD), a neurodegenerative movement disorder. PINK1 is a kinase that …
Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.
Rasool S, Veyron S, Soya N, Eldeeb MA, Lukacs GL, Fon EA, Trempe JF. Rasool S, et al. Mol Cell. 2022 Jan 6;82(1):44-59.e6. doi: 10.1016/j.molcel.2021.11.012. Epub 2021 Dec 6. Mol Cell. 2022. PMID: 34875213
Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage results in PINK1 import arrest on the translocase of the outer mitochondrial membrane (TOM) complex, resulting in the activation of its ubiquitin kinase activity by autophosphorylation a …
Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage results in PINK1 import arrest on the transloc …
The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria.
Maruszczak KK, Jung M, Rasool S, Trempe JF, Rapaport D. Maruszczak KK, et al. Among authors: rasool s. J Mol Med (Berl). 2022 May;100(5):747-762. doi: 10.1007/s00109-022-02191-6. Epub 2022 Apr 7. J Mol Med (Berl). 2022. PMID: 35391620 Free PMC article.
Mitochondria dysfunction is involved in the pathomechanism of many illnesses including Parkinson's disease. PINK1, which is mutated in some cases of familial Parkinsonism, is a key component in the degradation of damaged mitochondria by mitophagy. ...
Mitochondria dysfunction is involved in the pathomechanism of many illnesses including Parkinson's disease. PINK1, which is mutated i …
Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria.
Vranas M, Lu Y, Rasool S, Croteau N, Krett JD, Sauvé V, Gehring K, Fon EA, Durcan TM, Trempe JF. Vranas M, et al. Among authors: rasool s. Open Biol. 2022 Jan;12(1):210255. doi: 10.1098/rsob.210255. Epub 2022 Jan 19. Open Biol. 2022. PMID: 35042405 Free PMC article.
Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. Parkin is a RING-In-Between-RING E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: (i) thioester intermediate formation on Parkin and (ii) acyl transfer to a subst …
Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. Parkin is a RING-In-Between-RING E3 ligase that transfe …