New insights into the structure of PINK1 and the mechanism of ubiquitin phosphorylation.
Crit Rev Biochem Mol Biol. 2018 Oct;53(5):515-534. doi: 10.1080/10409238.2018.1491525. Epub 2018 Sep 21.
Crit Rev Biochem Mol Biol. 2018.
PMID: 30238821
Review.
Mutations in PINK1 cause early-onset recessive Parkinson's disease. This gene encodes a protein kinase implicated in mitochondrial quality control via ubiquitin phosphorylation and activation of the E3 ubiquitin ligase Parkin. ...
Mutations in PINK1 cause early-onset recessive Parkinson's disease. This gene encodes a protein kinase implicated in mitochondrial qu …