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Rationally designed multitarget anti-HIV agents.
Zhan P, Liu X. Zhan P, et al. Curr Med Chem. 2013;20(13):1743-58. doi: 10.2174/0929867311320130011. Curr Med Chem. 2013. PMID: 23410170 Review.
The exploration of MTDL strategy should be valuable in anti-HIV drug discovery. In this article, current knowledge and strategies for the rational design of the multitarget and selective anti-HIV agents are described and a n …
The exploration of MTDL strategy should be valuable in anti-HIV drug discovery. In this article, current knowledge and strateg …
Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase.
Gu SX, Xue P, Ju XL, Zhu YY. Gu SX, et al. Bioorg Med Chem. 2016 Nov 1;24(21):5007-5016. doi: 10.1016/j.bmc.2016.09.025. Epub 2016 Sep 12. Bioorg Med Chem. 2016. PMID: 27658796 Review.
Recently, rational drug design has become a dominant technique for the development of multi-target drugs. And the rationally designed dual inhibitors of HIV-1 RT and IN have become a hot topic of anti-HIV research. ...
Recently, rational drug design has become a dominant technique for the development of multi-target drugs. And the rationall …
Designed multiple ligands: an emerging anti-HIV drug discovery paradigm.
Zhan P, Liu X. Zhan P, et al. Curr Pharm Des. 2009;15(16):1893-917. doi: 10.2174/138161209788453266. Curr Pharm Des. 2009. PMID: 19519431 Review.
Designed multiple ligands (DMLs) therapy as an emerging anti-HIV drug discovery paradigm, using a single entity to inhibit multitargets could yield improved patient compliance, thus reducing the likelihood of drug resistance. The exploration of such mu …
Designed multiple ligands (DMLs) therapy as an emerging anti-HIV drug discovery paradigm, using a single entity to inhi …
[Research progress of dual inhibitors targeting HIV-1 reverse transcriptase and integrase].
Liu H, Zhan P, Liu XY. Liu H, et al. Yao Xue Xue Bao. 2013 Apr;48(4):466-76. Yao Xue Xue Bao. 2013. PMID: 23833931 Review. Chinese.
Combinatorial chemistry approach together with high throughput screening methods and multi-target-based virtual screening strategy have been useful tools for identifying selective anti-HIV compounds for long times; Rational drug design based on pharmac …
Combinatorial chemistry approach together with high throughput screening methods and multi-target-based virtual screening strategy have been …
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Furthermore, the high-resolution structures of SARS-CoV-2 3CLpro in complex with C2-C5a will facilitate future rational optimization of our novel broad-spectrum active-site-directed 3C-like protease inhibitors....
Furthermore, the high-resolution structures of SARS-CoV-2 3CLpro in complex with C2-C5a will facilitate future rational optimization …
In silico design of multi-target inhibitors for C-C chemokine receptors using substructural descriptors.
Speck-Planche A, Kleandrova VV. Speck-Planche A, et al. Mol Divers. 2012 Feb;16(1):183-91. doi: 10.1007/s11030-011-9337-y. Epub 2011 Oct 22. Mol Divers. 2012. PMID: 22020812
Rational design of entry inhibitors is an active area for the discovery of new and effective anti-HIV agents. C-C Chemokine receptors represent key targets for the HIV entry process. Several of these proteins with features to be HIV …
Rational design of entry inhibitors is an active area for the discovery of new and effective anti-HIV agents …
A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors.
Van Loock M, Meersseman G, Van Acker K, Van Den Eynde C, Jochmans D, Van Schoubroeck B, Dams G, Heyndrickx L, Clayton RF. Van Loock M, et al. J Virol Methods. 2012 Feb;179(2):396-401. doi: 10.1016/j.jviromet.2011.11.029. Epub 2011 Dec 7. J Virol Methods. 2012. PMID: 22172974
The discovery of HIV-1 integrase inhibitors has been enabled by high-throughput screening and rational design of novel chemotypes. ...Therefore, a cellular screening assay was developed, which focused on integrase activity, where infection of MT4 cells with a …
The discovery of HIV-1 integrase inhibitors has been enabled by high-throughput screening and rational design of novel …