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Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.
Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LB, Bjeldanes LF, Crews P. Johnson TA, et al. Among authors: ratnam j. J Nat Prod. 2011 Dec 27;74(12):2545-55. doi: 10.1021/np200673b. Epub 2011 Nov 30. J Nat Prod. 2011. PMID: 22129061 Free PMC article.
Mining a cathepsin inhibitor library for new antiparasitic drug leads.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: ratnam j. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.
Discovery of novel benzoxaborole-based potent antitrypanosomal agents.
Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ. Ding D, et al. Among authors: ratnam j. ACS Med Chem Lett. 2010 Apr 6;1(4):165-9. doi: 10.1021/ml100013s. eCollection 2010 Jul 8. ACS Med Chem Lett. 2010. PMID: 24900190 Free PMC article.
Novel cruzain inhibitors for the treatment of Chagas' disease.
Rogers KE, Keränen H, Durrant JD, Ratnam J, Doak A, Arkin MR, McCammon JA. Rogers KE, et al. Among authors: ratnam j. Chem Biol Drug Des. 2012 Sep;80(3):398-405. doi: 10.1111/j.1747-0285.2012.01416.x. Epub 2012 Jun 27. Chem Biol Drug Des. 2012. PMID: 22613098 Free PMC article.
37 results