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eIF4E activity is regulated at multiple levels.
Raught B, Gingras AC. Raught B, et al. Int J Biochem Cell Biol. 1999 Jan;31(1):43-57. doi: 10.1016/s1357-2725(98)00131-9. Int J Biochem Cell Biol. 1999. PMID: 10216943 Review.
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.
Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DL. Manshouri R, et al. Among authors: raught b. Nat Commun. 2019 Nov 12;10(1):5125. doi: 10.1038/s41467-019-12832-z. Nat Commun. 2019. PMID: 31719531 Free PMC article.
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.
Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D. Lu Y, et al. Among authors: raught b. Science. 2019 Oct 25;366(6464):460-467. doi: 10.1126/science.aau6391. Epub 2019 Oct 24. Science. 2019. PMID: 31649195
Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Frendo-Cumbo S, Jaldin-Fincati JR, Coyaud E, Laurent EMN, Townsend LK, Tan JMJ, Xavier RJ, Pillon NJ, Raught B, Wright DC, Brumell JH, Klip A. Frendo-Cumbo S, et al. Among authors: raught b. J Biol Chem. 2019 Nov 1;294(44):16172-16185. doi: 10.1074/jbc.RA119.009110. Epub 2019 Sep 12. J Biol Chem. 2019. PMID: 31515271 Free PMC article.
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Mirali S, Botham A, Voisin V, Xu C, St-Germain J, Sharon D, Hoff FW, Qiu Y, Hurren R, Gronda M, Jitkova Y, Nachmias B, MacLean N, Wang X, Arruda A, Minden MD, Horton TM, Kornblau SM, Chan SM, Bader GD, Raught B, Schimmer AD. Mirali S, et al. Among authors: raught b. Sci Transl Med. 2020 Apr 8;12(538):eaaz8264. doi: 10.1126/scitranslmed.aaz8264. Sci Transl Med. 2020. PMID: 32269163
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