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Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Frendo-Cumbo S, Jaldin-Fincati JR, Coyaud E, Laurent EMN, Townsend LK, Tan JMJ, Xavier RJ, Pillon NJ, Raught B, Wright DC, Brumell JH, Klip A. Frendo-Cumbo S, et al. J Biol Chem. 2019 Nov 1;294(44):16172-16185. doi: 10.1074/jbc.RA119.009110. Epub 2019 Sep 12. J Biol Chem. 2019. PMID: 31515271
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Botham A, Coyaud E, Nirmalanandhan VS, Gronda M, Hurren R, Maclean N, St-Germain J, Mirali S, Laurent E, Raught B, Schimmer A. Botham A, et al. Proteomics. 2019 Dec;19(24):e1900139. doi: 10.1002/pmic.201900139. Proteomics. 2019. PMID: 31617661
BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.
Chan CJ, Le R, Burns K, Ahmed K, Coyaud E, Laurent EMN, Raught B, Melançon P. Chan CJ, et al. Mol Cell Proteomics. 2019 Nov;18(11):2285-2297. doi: 10.1074/mcp.RA119.001645. Epub 2019 Sep 13. Mol Cell Proteomics. 2019. PMID: 31519766
A novel functional human eukaryotic translation initiation factor 4G.
Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N. Gradi A, et al. Mol Cell Biol. 1998 Jan;18(1):334-42. doi: 10.1128/mcb.18.1.334. Mol Cell Biol. 1998. PMID: 9418880 Free PMC article.
eIF4E activity is regulated at multiple levels.
Raught B, Gingras AC. Raught B, et al. Int J Biochem Cell Biol. 1999 Jan;31(1):43-57. doi: 10.1016/s1357-2725(98)00131-9. Int J Biochem Cell Biol. 1999. PMID: 10216943 Review.
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Gingras AC, et al. Genes Dev. 1999 Jun 1;13(11):1422-37. doi: 10.1101/gad.13.11.1422. Genes Dev. 1999. PMID: 10364159 Free PMC article.
Regulation of translation initiation by FRAP/mTOR.
Gingras AC, Raught B, Sonenberg N. Gingras AC, et al. Genes Dev. 2001 Apr 1;15(7):807-26. doi: 10.1101/gad.887201. Genes Dev. 2001. PMID: 11297505 Review. No abstract available.
The target of rapamycin (TOR) proteins.
Raught B, Gingras AC, Sonenberg N. Raught B, et al. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7037-44. doi: 10.1073/pnas.121145898. Proc Natl Acad Sci U S A. 2001. PMID: 11416184 Free PMC article. Review.
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