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MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA. Brischwein K, et al. Among authors: raum t. Mol Immunol. 2006 Mar;43(8):1129-43. doi: 10.1016/j.molimm.2005.07.034. Epub 2005 Sep 1. Mol Immunol. 2006. PMID: 16139892
A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.
Krinner EM, Raum T, Petsch S, Bruckmaier S, Schuster I, Petersen L, Cierpka R, Abebe D, Mølhøj M, Wolf A, Sørensen P, Locher M, Baeuerle PA, Hepp J. Krinner EM, et al. Among authors: raum t. Mol Immunol. 2007 Feb;44(5):916-25. doi: 10.1016/j.molimm.2006.03.020. Epub 2006 May 11. Mol Immunol. 2007. PMID: 16697465
A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration.
Krinner EM, Hepp J, Hoffmann P, Bruckmaier S, Petersen L, Petsch S, Parr L, Schuster I, Mangold S, Lorenczewski G, Lutterbüse P, Buziol S, Hochheim I, Volkland J, Mølhøj M, Sriskandarajah M, Strasser M, Itin C, Wolf A, Basu A, Yang K, Filpula D, Sørensen P, Kufer P, Baeuerle P, Raum T. Krinner EM, et al. Among authors: raum t. Protein Eng Des Sel. 2006 Oct;19(10):461-70. doi: 10.1093/protein/gzl031. Epub 2006 Jul 25. Protein Eng Des Sel. 2006. PMID: 16868004
Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA.
Lutterbuese R, Raum T, Kischel R, Lutterbuese P, Schlereth B, Schaller E, Mangold S, Rau D, Meier P, Kiener PA, Mulgrew K, Oberst MD, Hammond SA, Baeuerle PA, Kufer P. Lutterbuese R, et al. Among authors: raum t. J Immunother. 2009 May;32(4):341-52. doi: 10.1097/CJI.0b013e31819b7c70. J Immunother. 2009. PMID: 19342971
Antitumor activity of an EpCAM/CD3-bispecific BiTE antibody during long-term treatment of mice in the absence of T-cell anergy and sustained cytokine release.
Amann M, D'Argouges S, Lorenczewski G, Brischwein K, Kischel R, Lutterbuese R, Mangold S, Rau D, Volkland J, Pflanz S, Raum T, Münz M, Kufer P, Schlereth B, Baeuerle PA, Friedrich M. Amann M, et al. Among authors: raum t. J Immunother. 2009 Jun;32(5):452-64. doi: 10.1097/CJI.0b013e3181a1c097. J Immunother. 2009. PMID: 19609237
Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells.
Steigerwald J, Raum T, Pflanz S, Cierpka R, Mangold S, Rau D, Hoffmann P, Kvesic M, Zube C, Linnerbauer S, Lumsden J, Sriskandarajah M, Kufer P, Baeuerle PA, Volkland J. Steigerwald J, et al. Among authors: raum t. MAbs. 2009 Mar-Apr;1(2):115-27. doi: 10.4161/mabs.1.2.7630. Epub 2009 Mar 11. MAbs. 2009. PMID: 20061825 Free PMC article.
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