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Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Marini C, Salani B, Massollo M, Amaro A, Esposito AI, Orengo AM, Capitanio S, Emionite L, Riondato M, Bottoni G, Massara C, Boccardo S, Fabbi M, Campi C, Ravera S, Angelini G, Morbelli S, Cilli M, Cordera R, Truini M, Maggi D, Pfeffer U, Sambuceti G. Marini C, et al. Among authors: ravera s. Cell Cycle. 2013 Nov 15;12(22):3490-9. doi: 10.4161/cc.26461. Cell Cycle. 2013. PMID: 24240433 Free PMC article.
IGF1 regulates PKM2 function through Akt phosphorylation.
Salani B, Ravera S, Amaro A, Salis A, Passalacqua M, Millo E, Damonte G, Marini C, Pfeffer U, Sambuceti G, Cordera R, Maggi D. Salani B, et al. Among authors: ravera s. Cell Cycle. 2015;14(10):1559-67. doi: 10.1080/15384101.2015.1026490. Cell Cycle. 2015. PMID: 25790097 Free PMC article.
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.
Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. Bianchi G, et al. Among authors: ravera s. Oncotarget. 2015 May 20;6(14):11806-19. doi: 10.18632/oncotarget.3688. Oncotarget. 2015. PMID: 25909219 Free PMC article.
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
Marini C, Bianchi G, Buschiazzo A, Ravera S, Martella R, Bottoni G, Petretto A, Emionite L, Monteverde E, Capitanio S, Inglese E, Fabbi M, Bongioanni F, Garaboldi L, Bruzzi P, Orengo AM, Raffaghello L, Sambuceti G. Marini C, et al. Among authors: ravera s. Sci Rep. 2016 Jan 22;6:19569. doi: 10.1038/srep19569. Sci Rep. 2016. PMID: 26794854 Free PMC article.
Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt.
Marini C, Ravera S, Buschiazzo A, Bianchi G, Orengo AM, Bruno S, Bottoni G, Emionite L, Pastorino F, Monteverde E, Garaboldi L, Martella R, Salani B, Maggi D, Ponzoni M, Fais F, Raffaghello L, Sambuceti G. Marini C, et al. Among authors: ravera s. Sci Rep. 2016 Apr 28;6:25092. doi: 10.1038/srep25092. Sci Rep. 2016. PMID: 27121192 Free PMC article.
Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
Colla R, Izzotti A, De Ciucis C, Fenoglio D, Ravera S, Speciale A, Ricciarelli R, Furfaro AL, Pulliero A, Passalacqua M, Traverso N, Pronzato MA, Domenicotti C, Marengo B. Colla R, et al. Among authors: ravera s. Oncotarget. 2016 Oct 25;7(43):70715-70737. doi: 10.18632/oncotarget.12209. Oncotarget. 2016. PMID: 27683112 Free PMC article.
252 results