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A phase I study of ATR inhibitor gartisertib (M4344) as a single agent and in combination with carboplatin in patients with advanced solid tumours.
Burris HA, Berlin J, Arkenau T, Cote GM, Lolkema MP, Ferrer-Playan J, Kalapur A, Bolleddula J, Locatelli G, Goddemeier T, Gounaris I, de Bono J. Burris HA, et al. Br J Cancer. 2024 Apr;130(7):1131-1140. doi: 10.1038/s41416-023-02436-2. Epub 2024 Jan 29. Br J Cancer. 2024. PMID: 38287179 Free PMC article. Clinical Trial.
METHODS: This phase I open-label, multicenter, first-in-human study comprised four gartisertib cohorts: A (dose escalation [DE]; Q2W); A2 (DE; QD/BID); B1 (DE+carboplatin); and C (biomarker-selected patients). RESULTS: Overall, 97 patients were enroled into cohorts A (n = …
METHODS: This phase I open-label, multicenter, first-in-human study comprised four gartisertib cohorts: A (dose escalation [DE]; Q2W); A2 (D …
Efficacy of Transarterial Chemoembolization (TACE) for Early-Stage Hepatocellular Carcinoma.
Lee M, Shin HP. Lee M, et al. Medicina (Kaunas). 2023 Dec 14;59(12):2174. doi: 10.3390/medicina59122174. Medicina (Kaunas). 2023. PMID: 38138277 Free PMC article.
Materials and Methods: A retrospective analysis was performed of all TACE procedures performed at Kyung Hee University Hospital at Gangdong over a 15-year period (July 2006 to November 2021). The study included a total of 97 eligible patients with early-stage HCC 5 cm init …
Materials and Methods: A retrospective analysis was performed of all TACE procedures performed at Kyung Hee University Hospital at Gangdong …
Delta Radiomics Based on Longitudinal Dual-modal Ultrasound Can Early Predict Response to Neoadjuvant Chemotherapy in Breast Cancer Patients.
Huang JX, Wu L, Wang XY, Lin SY, Xu YF, Wei MJ, Pei XQ. Huang JX, et al. Acad Radiol. 2023 Dec 5:S1076-6332(23)00606-2. doi: 10.1016/j.acra.2023.10.051. Online ahead of print. Acad Radiol. 2023. PMID: 38057180
RESULTS: The area under receiver operating characteristic curve (AUC) values of R(BUS) (C2) and R(BUS) (C4) for predicting the response to NAC were 0.83 and 0.84, while those of R(SWE) (C2) and R(SWE) (C4) were 0.88 and 0.90, respectively. ...No significant differen …
RESULTS: The area under receiver operating characteristic curve (AUC) values of R(BUS) (C2) and R(BUS) (C4) for predicting the respon …
Breaching the Fortress: Photochemistry of DNA-Caged Ag106.
Setzler CJ, Arrington CA, Lewis D, Petty JT. Setzler CJ, et al. J Phys Chem B. 2023 Dec 21;127(50):10851-10860. doi: 10.1021/acs.jpcb.3c06358. Epub 2023 Dec 6. J Phys Chem B. 2023. PMID: 38054435 Free PMC article.
Ethnic sensitivity assessment: Polatuzumab vedotin pharmacokinetics in Asian and non-Asian patients with previously untreated diffuse large B-cell lymphoma in POLARIX.
Liao MZ, Deng R, Gibiansky L, Lu T, Agarwal P, Dere R, Lee C, Hirata J, Herbaux C, Salles G, Li C, Miles D. Liao MZ, et al. Clin Transl Sci. 2023 Dec;16(12):2744-2755. doi: 10.1111/cts.13669. Epub 2023 Oct 31. Clin Transl Sci. 2023. PMID: 37864313 Free PMC article.
In patients from Asia versus outside Asia, observed mean antibody-conjugated monomethyl auristatin E (acMMAE) concentrations were comparable (1.2% lower at cycle [C]1 postdose, 4.4% higher at C4 predose; and 6.8% lower at C4 postdose in patients from Asia). Observed …
In patients from Asia versus outside Asia, observed mean antibody-conjugated monomethyl auristatin E (acMMAE) concentrations were comparable …
[Distal pancreatectomy with celiac axis resection for pancreatic body cancer: a single center review of 89 consecutive cases].
Huang XM, Zhang K, Yin J, Wu PF, Cai BB, Lu ZP, Tu M, Chen JM, Guo F, Xi CH, Wei JS, Wu JL, Gao WT, Dai CC, Miao Y, Jiang KR. Huang XM, et al. Zhonghua Wai Ke Za Zhi. 2023 Oct 1;61(10):894-900. doi: 10.3760/cma.j.cn112139-20230327-00123. Zhonghua Wai Ke Za Zhi. 2023. PMID: 37653992 Chinese.
The increase rate in transient liver enzymes was 42.7% (38/89),3.4% (3/89) for liver failure,53.9% (48/89) for clinically relevant postoperative pancreatic fistula,1.1% (1/89) for bile leak,3.4% (3/89) for chylous leak of grade B and C,11.2% (10/89) for abdominal infection …
The increase rate in transient liver enzymes was 42.7% (38/89),3.4% (3/89) for liver failure,53.9% (48/89) for clinically relevant postopera …
Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients.
Butler AE, Moin ASM, Sathyapalan T, Atkin SL. Butler AE, et al. Cells. 2023 Aug 4;12(15):2002. doi: 10.3390/cells12152002. Cells. 2023. PMID: 37566081 Free PMC article.

There was no association with insulin resistance. BMI correlated positively in both groups with factor B, factor H and C5a. Additionally, in obese PCOS, BMI correlated with C3d, factor D, factor I, CFHR5 and C5a (p < 0.05), and in nonobese PCOS, BMI correlated with prop

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There was no association with insulin resistance. BMI correlated positively in both groups with factor B, factor H and C5a. Additiona …
Occult hepatitis B in blood donation centers.
AlRashdan Y, Al-Jaff K, Najdawi M, Sirhan A. AlRashdan Y, et al. J Med Life. 2023 Apr;16(4):571-578. doi: 10.25122/jml-2023-0054. J Med Life. 2023. PMID: 37305817 Free PMC article.
Occult hepatitis B (OHB) is characterized by the presence of hepatitis B virus (HBV) DNA in the blood of individuals who test negative for the hepatitis B surface antigen (HBsAg). ...We measured levels of IgG, IgM, complement components (C3 and C4), AL …
Occult hepatitis B (OHB) is characterized by the presence of hepatitis B virus (HBV) DNA in the blood of individuals who test …
Alternative Complement Pathway Inhibition by Lampalizumab: Analysis of Data From Chroma and Spectri Phase III Clinical Trials.
Edmonds R, Steffen V, Honigberg LA, Chang MC. Edmonds R, et al. Ophthalmol Sci. 2023 Feb 13;3(3):100286. doi: 10.1016/j.xops.2023.100286. eCollection 2023 Sep. Ophthalmol Sci. 2023. PMID: 37228694 Free PMC article.
DESIGN: Chroma/Spectri were double-masked, sham-controlled, 96-week trials. PARTICIPANTS: Aqueous humor samples from 97 patients with bilateral GA across all groups (i.e., intravitreous lampalizumab 10 mg every 6 weeks, every 4 weeks, or corresponding sham procedures) were …
DESIGN: Chroma/Spectri were double-masked, sham-controlled, 96-week trials. PARTICIPANTS: Aqueous humor samples from 97 patients with …
Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation.
Yang S, Wang A, Li J, Shao Y, Sun F, Li S, Cao K, Liu H, Xiong P, Gao Z. Yang S, et al. Microb Cell Fact. 2023 May 18;22(1):102. doi: 10.1186/s12934-023-02077-3. Microb Cell Fact. 2023. PMID: 37198628 Free PMC article.
Knockouts of uroporphyrinogen methyltransferase gene nasF and both heme monooxygenase genes hmoA and hmoB in the downstream synthesis pathway increased heme production by 52%. The engineered B. subtilis produced 248.26 6.97 mg/L of total heme with 221.83 4.71 mg/L o …
Knockouts of uroporphyrinogen methyltransferase gene nasF and both heme monooxygenase genes hmoA and hmoB in the downstream synthesis pathwa …
232 results