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Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention.
Cleary MP, Ray A, Rogozina OP, Dogan S, Grossmann ME. Cleary MP, et al. Front Biosci (Schol Ed). 2009 Jun 1;1:329-57. Front Biosci (Schol Ed). 2009. PMID: 19482706 Review.
Obesity is a risk factor for postmenopausal breast cancer. Elevated estrogen levels are thought to be a growth factor associated with this relationship. ...
Obesity is a risk factor for postmenopausal breast cancer. Elevated estrogen levels are thought to be a growth factor associat …
Obesity and breast cancer: a clinical biochemistry perspective.
Ray A, Cleary MP. Ray A, et al. Clin Biochem. 2012 Feb;45(3):189-97. doi: 10.1016/j.clinbiochem.2011.11.016. Epub 2011 Dec 8. Clin Biochem. 2012. PMID: 22178111 Review.
There is a need to elucidate different biochemical markers that are being used in the clinics or have the potential for such use. A precise understanding of the complex pathologies related with obesity is useful in prevention, early diagnosis and overall clinical ma …
There is a need to elucidate different biochemical markers that are being used in the clinics or have the potential for such use. …
Obesity and breast cancer: status of leptin and adiponectin in pathological processes.
Grossmann ME, Ray A, Nkhata KJ, Malakhov DA, Rogozina OP, Dogan S, Cleary MP. Grossmann ME, et al. Cancer Metastasis Rev. 2010 Dec;29(4):641-53. doi: 10.1007/s10555-010-9252-1. Cancer Metastasis Rev. 2010. PMID: 20821253 Review.
Higher circulating levels of leptin found in obese subjects could be a growth-enhancing factor as supported by in vitro and preclinical studies, whereas low adiponectin levels in obese women may be permissive for leptin's growth-promoting effects. ...Further, estrogen and …
Higher circulating levels of leptin found in obese subjects could be a growth-enhancing factor as supported by in vitro and preclinic …
Role of the adiponectin leptin ratio in prostate cancer.
Grossmann ME, Mizuno NK, Bonorden MJ, Ray A, Sokolchik I, Narasimhan ML, Cleary MP. Grossmann ME, et al. Oncol Res. 2009;18(5-6):269-77. doi: 10.3727/096504009x12596189659367. Oncol Res. 2009. PMID: 20225764
We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. ...
We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that …
Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism.
Grossmann ME, Mizuno NK, Dammen ML, Schuster T, Ray A, Cleary MP. Grossmann ME, et al. Cancer Prev Res (Phila). 2009 Oct;2(10):879-86. doi: 10.1158/1940-6207.CAPR-09-0088. Epub 2009 Sep 29. Cancer Prev Res (Phila). 2009. PMID: 19789297
Eleostearic acid (alpha-ESA) is a conjugated linolenic acid that makes up approximately 60% of Momordica charantia (bitter melon) seed oil. ...Additionally, alpha-ESA caused a G(2)-M block in the cell cycle. We also investigated the potential for lipid peroxidation …
Eleostearic acid (alpha-ESA) is a conjugated linolenic acid that makes up approximately 60% of Momordica charantia (bitter melon) see …
Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements.
Nkhata KJ, Ray A, Dogan S, Grande JP, Cleary MP. Nkhata KJ, et al. Breast Cancer Res Treat. 2009 Mar;114(1):71-83. doi: 10.1007/s10549-008-9991-7. Epub 2008 Apr 6. Breast Cancer Res Treat. 2009. PMID: 18392696
Obesity is a risk factor for postmenopausal breast cancer, particularly for development of estrogen-receptor (ER)-positive tumors. ...GTG-obese mice with placebo pellets had a 100% tumor incidence compared to 50% and 20% for GTG-lean and controls without estrogen. . …
Obesity is a risk factor for postmenopausal breast cancer, particularly for development of estrogen-receptor (ER)-positive tumors. .. …
Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status.
Ray A, Nkhata KJ, Cleary MP. Ray A, et al. Int J Oncol. 2007 Jun;30(6):1499-509. Int J Oncol. 2007. PMID: 17487372
Obesity is a risk factor for postmenopausal breast cancer and is associated with poor prognosis. Leptin, a cytokine synthesized in adipose tissue, has been implicated as a link between obesity and breast cancer. ...A similar trend was found for IGF-I a …
Obesity is a risk factor for postmenopausal breast cancer and is associated with poor prognosis. Leptin, a cytokine synthesize …
Cancer preventive role of selected dietary factors.
Ray A. Ray A. Indian J Cancer. 2005 Jan-Mar;42(1):15-24. doi: 10.4103/0019-509x.15095. Indian J Cancer. 2005. PMID: 15805687 Review.
Dietary phenolic and polyphenolic substances, terpenoids, dietary fibers, fish oils, some micronutrients present in foods of both plant and animal origin, and a reduction of caloric intake appear to inhibit the process of cancer development. ...Further, isothiocyanates of …
Dietary phenolic and polyphenolic substances, terpenoids, dietary fibers, fish oils, some micronutrients present in foods of both plant and …
Diet-induced obesity and mammary tumor development in relation to estrogen receptor status.
Ray A, Nkhata KJ, Grande JP, Cleary MP. Ray A, et al. Cancer Lett. 2007 Aug 18;253(2):291-300. doi: 10.1016/j.canlet.2007.02.005. Epub 2007 Mar 30. Cancer Lett. 2007. PMID: 17399892
Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. ...
Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed …
The influence of different calorie restriction protocols on serum pro-inflammatory cytokines, adipokines and IGF-I levels in female C57BL6 mice: short term and long term diet effects.
Dogan S, Ray A, Cleary MP. Dogan S, et al. Meta Gene. 2017 Jun;12:22-32. doi: 10.1016/j.mgene.2016.12.013. Epub 2017 Jan 3. Meta Gene. 2017. PMID: 28373962 Free PMC article.
There was a trend for adiponectin and insulin to be highest in ICR-RF mice. Body weights were positively correlated with IL-6, TNF-α, insulin and leptin but negatively correlated with adiponectin-to-leptin ratio. Moreover, there was a positive correlation between IL …
There was a trend for adiponectin and insulin to be highest in ICR-RF mice. Body weights were positively correlated with IL-6, TNF-α, …
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