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Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells.
Bera S, Wallimann T, Ray S, Ray M. Bera S, et al. FEBS J. 2008 Dec;275(23):5899-909. doi: 10.1111/j.1742-4658.2008.06718.x. FEBS J. 2008. PMID: 19021765
Transcript levels of arginase II, ornithine-decarboxylase, S-adenosyl-homocysteine hydrolase and methionine-synthase were significantly upregulated in sarcoma and in Ehrlich ascites carcinoma and Sarcoma 180 cells. ...
Transcript levels of arginase II, ornithine-decarboxylase, S-adenosyl-homocysteine hydrolase and methionine-synthase were significant …
Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect.
Pal A, Talukdar D, Roy A, Ray S, Mallick A, Mandal C, Ray M. Pal A, et al. Int J Nanomedicine. 2015 May 12;10:3499-518. doi: 10.2147/IJN.S78284. eCollection 2015. Int J Nanomedicine. 2015. PMID: 25999714 Free PMC article.
MATERIALS AND METHODS: MG-conjugated chitosan nanoparticles (Nano-MG) were prepared by conjugating the carbonyl group of MG with the amino group of chitosan polymer (Schiff's base formation). ...
MATERIALS AND METHODS: MG-conjugated chitosan nanoparticles (Nano-MG) were prepared by conjugating the carbonyl group of MG with the amino g …
Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Das MR, Bag AK, Saha S, Ghosh A, Dey SK, Das P, Mandal C, Ray S, Chakrabarti S, Ray M, Jana SS. Das MR, et al. BMC Cancer. 2016 Feb 24;16:152. doi: 10.1186/s12885-016-2172-x. BMC Cancer. 2016. PMID: 26911935 Free PMC article.
A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy.
Patra S, Ghosh A, Roy SS, Bera S, Das M, Talukdar D, Ray S, Wallimann T, Ray M. Patra S, et al. Amino Acids. 2012 Jun;42(6):2319-30. doi: 10.1007/s00726-011-0974-3. Epub 2011 Jul 19. Amino Acids. 2012. PMID: 21769499 Review.
A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients.
Talukdar D, Ray S, Ray M, Das S. Talukdar D, et al. Drug Metabol Drug Interact. 2008;23(1-2):175-210. doi: 10.1515/dmdi.2008.23.1-2.175. Drug Metabol Drug Interact. 2008. PMID: 18533369 Review.
The results of these investigations led to the proposal that the fundamental changes in malignant cells are critical alterations of glyceraldehyde-3-phosphate dehydrogenase and mitochondrial complex I, and methylglyoxal's anticancer effect might be mediated by acting on th …
The results of these investigations led to the proposal that the fundamental changes in malignant cells are critical alterations of glyceral …
Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma.
Patra S, Bera S, SinhaRoy S, Ghoshal S, Ray S, Basu A, Schlattner U, Wallimann T, Ray M. Patra S, et al. FEBS J. 2008 Jun;275(12):3236-47. doi: 10.1111/j.1742-4658.2008.06475.x. Epub 2008 May 13. FEBS J. 2008. PMID: 18485002
In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine.
Ghosh M, Talukdar D, Ghosh S, Bhattacharyya N, Ray M, Ray S. Ghosh M, et al. Toxicol Appl Pharmacol. 2006 Apr 1;212(1):45-58. doi: 10.1016/j.taap.2005.07.003. Epub 2005 Aug 19. Toxicol Appl Pharmacol. 2006. PMID: 16112157
Protective effect of creatine against inhibition by methylglyoxal of mitochondrial respiration of cardiac cells.
Roy SS, Biswas S, Ray M, Ray S. Roy SS, et al. Biochem J. 2003 Jun 1;372(Pt 2):661-9. doi: 10.1042/BJ20021576. Biochem J. 2003. PMID: 12605598 Free PMC article.
Previous publications from our laboratory have shown that methylglyoxal inhibits mitochondrial respiration of malignant and cardiac cells, but it has no effect on mitochondrial respiration of other normal cells [Biswas, Ray, Misra, Dutta and Ray (1997) Biochem. J. 3 …
Previous publications from our laboratory have shown that methylglyoxal inhibits mitochondrial respiration of malignant and cardiac cells, b …
Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.
SinhaRoy S, Banerjee S, Ray M, Ray S. SinhaRoy S, et al. Mol Cell Biochem. 2005 Mar;271(1-2):167-76. doi: 10.1007/s11010-005-6277-9. Mol Cell Biochem. 2005. PMID: 15881668
We had previously shown that creatine exerted a protective effect against inhibition of cardiac mitochondrial respiration by methylglyoxal (SinhaRoy S, Biswas S, Ray M, Ray S. ...This result suggests the presence of carboxylic acid(s) suc …
We had previously shown that creatine exerted a protective effect against inhibition of cardiac mitochondrial respiration by methylglyoxal ( …
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