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Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice.
Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD. Aird WC, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4567-71. doi: 10.1073/pnas.92.10.4567. Proc Natl Acad Sci U S A. 1995. PMID: 7753844 Free PMC article.
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.
Healy AM, Rayburn HB, Rosenberg RD, Weiler H. Healy AM, et al. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):850-4. doi: 10.1073/pnas.92.3.850. Proc Natl Acad Sci U S A. 1995. PMID: 7846065 Free PMC article.
Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses.
Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Hartwell DW, et al. J Cell Biol. 1998 Nov 16;143(4):1129-41. doi: 10.1083/jcb.143.4.1129. J Cell Biol. 1998. PMID: 9817767 Free PMC article.
Furthermore, the neutrophil influx into the inflamed peritoneum was only 30% of the wild-type level 2 h after stimulation. Our results suggest that different sorting mechanisms for P-selectin are used in platelets and endothelial cells and that the storage pool of P-select …
Furthermore, the neutrophil influx into the inflamed peritoneum was only 30% of the wild-type level 2 h after stimulation. Our result …
A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.
Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, Edelberg JM, Rosenberg RD. Weiler-Guettler H, et al. J Clin Invest. 1998 May 1;101(9):1983-91. doi: 10.1172/JCI2006. J Clin Invest. 1998. PMID: 9576763 Free PMC article.
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.
Robinson SD, Frenette PS, Rayburn H, Cummiskey M, Ullman-Culleré M, Wagner DD, Hynes RO. Robinson SD, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11452-7. doi: 10.1073/pnas.96.20.11452. Proc Natl Acad Sci U S A. 1999. PMID: 10500197 Free PMC article.
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