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Rb selectively inhibits innate IFN-beta production by enhancing deacetylation of IFN-beta promoter through HDAC1 and HDAC8.
Meng J, Liu X, Zhang P, Li D, Xu S, Zhou Q, Guo M, Huai W, Chen X, Wang Q, Li N, Cao X. Meng J, et al. J Autoimmun. 2016 Sep;73:42-53. doi: 10.1016/j.jaut.2016.05.012. Epub 2016 Jun 4. J Autoimmun. 2016. PMID: 27267461
Rb selectively bound Ifnb1 enhancer region, but not the promoter of Ifna4, Tnf and Il6, by interacting with c-Jun, the component of IFN-beta enhanceosome. ...Therefore, Rb selectively inhibits innate IFN …
Rb selectively bound Ifnb1 enhancer region, but not the promoter of Ifna4, Tnf and Il6, by interacting with c-Ju …